The Investigating of Photoplethysmogram Waveform Amplitude Changes: Aging and Atherosclerosis

This paper focuses on the analysis of PPG waveform amplitude changes. As PPG signal reflects blood volume changes, studying its (peaks and valleys) amplitudes changes is highly appreciated. The results showed a strong positive relationship between age and RI index (R square = 0.657) and a strongly negative relationship between age and systolic peak index (R square = -0.651). The obtained results underline the importance of studying PPG's (peaks and valleys) amplitude changes and their association with age and atherosclerosis. The association between aging, atherosclerosis, arterial stiffness and PPG's morphology can provide a fruitful tool towards disease prevention and early-risk prediction. The increment of systolic peak as we age might indicate the present of atherosclerosis and the start of arterial stiffness. In addition, the increment of RI index as we age, may contribute to the process of high-risk atherosclerosis prediction and therefore approaching risk prevention

Countering Malicious URLs in Internet of Things Using a Knowledge-Based Approach and a Simulated Expert

© 2014 IEEE. This article proposes a novel methodology to detect malicious uniform resource locators (URLs) using simulated expert (SE) and knowledge-base system (KBS). The proposed study not only efficiently detects known malicious URLs but also adapts countermeasure against the newly generated malicious URLs. Moreover, this article also explored which lexical features are contributing more in final decision using a factor analysis method, and thus help in avoiding the involvement of human experts. Furthermore, we apply the following state-of-the-art machine learning (ML) algorithms, i.e., naïve Bayes (NB), decision tree (DT), gradient boosted trees (GBT), generalized linear model (GLM), logistic regression (LR), deep learning (DL), and random rest (RF), and evaluate the performance of these algorithms on a large-scale real data set of data-driven Web applications. The experimental results clearly demonstrate the efficiency of NB in the proposed model as NB outperforms when compared to the rest of the aforementioned algorithms in terms of average minimum execution time (i.e., 3 s) and is able to accurately classify the 107 586 URLs with 0.2% error rate and 99.8% accuracy rate

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. Methods The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model—a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates—with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality—which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. Findings The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2–100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1–290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1–211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4–48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3–37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7–9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. Interpretation Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere

Design and Performance Optimisation of the Hexaboards for CMS HGCAL On-Cassette Readout Electronics

A new high-granularity endcap calorimeter, HGCAL, is foreseen to be installed later this decade in the CMS experiment. We present the design and performance of the Hexaboard, a complex hexagonal multi-layer PCB equipped with multiple HGCROC ASICs to read out the signals from silicon pads with low noise and large dynamic range. The Hexaboards are glued to silicon sensors and connect to their pads via wire bonds through holes in the PCBs. The Hexaboard also connects to mezzanine boards for powering, trigger and data concentration and transfer. More than ten variants of the Hexa\-board are required to cover the circular fiducial area of the CMS endcaps. Detailed performance measurements, and comparative PCB simulations using Ansys SIwave, are presented

Energy-efficient Harvested-Aware clustering and cooperative Routing Protocol for WBAN (E-HARP)

Wireless Body Area Network (WBAN) is an interconnection of small bio-sensor nodes that are deployed in/on different parts of human body. It is used to sense health-related data such as rate of heart beat, blood pressure, blood glucose level, Electro-cardiogram (ECG), Electro-myography (EMG) etc. of human body and pass these readings to real-time health monitoring systems. WBANs is an important research area and is used in different applications such as medical field, sports, entertainment, social welfare etc. Bio-Sensor Nodes (BSNs) or simply called as Sensor Nodes (SNs) are the main backbone of WBANs. SNs normally have very limited resources due to its smaller size. Therefore, minimum consumption of energy is an essential design requirement of WBAN schemes. In the proposed work, Energy-efficient Harvested-Aware clustering and cooperative Routing Protocol for WBAN (E-HARP) are presented. The presented protocol mainly proposes a novel multi-attribute-based technique for dynamic Cluster Head (CH) selection and cooperative routing. In the first phase of this two-phased technique, optimum CH is selected among the cluster members, based on calculated Cost Factor (CF). The parameters used for calculation of CF are; residual energy of SN, required transmission power, communication link Signal-to-Noise-Ratio (SNR) and total network energy loss. In order to distribute load on one CH, E-HARP selects new CH in each data transmission round. In the second phase of E-HARP, data is routed with cooperative effort of the SN, which saves the node energy by prohibiting the transmission of redundant data packets. To evaluate the performance of the proposed technique, comprehensive experimentations using NS-2 simulation tool has been conducted. The results are compared with some latest techniques named as EH-RCB, ELR-W, Co-LAEEBA, and EECBSR. The acquired results show a significant enhancement of E-HARP in terms of network stability, network life time, throughput, end-to-end delay and packet delivery ratio

Privacy by Architecture Pseudonym Framework for Delay Tolerant Network

Delay Tolerant Network (DTN) enables communication in opportunistic networks where disruptive links result into intermittent connectivity. Routing protocols in such opportunistic environments mainly rely on broadcast/multicast communication in order to maximize the chances of packet delivery to destination node. Lack of end-to-end path and the essential requirement of store-carry-forward decision of packets by intermediate nodes, pose a serious threat to security and privacy concerns in DTNs. This article proposes a novel approach for secure and private communication in DTNs by hiding the identity of nodes using pseudonyms. The approach is based on Privacy by Architecture (PbA) where minimal identifying information of a user is sent to a certificate authority (CA) while requesting for a certificate. The novel PbA based scheme is composed of a set of protocols to address the aforementioned challenges; the Pseudonym Credential and Pseudonym Identity/Certificate Issuance protocols. The proposed approach is validated using formal modeling in CasperFDR which is the state-of-the art compiler for performance analysis of security protocols. To strengthen our claim, an information theoretic quantification method is employed to measure the Degree of Anonymity (DoA) of the approach. The approach performs efficiently and requires no end-to-end connectivity for messages exchange between the user and the certificate authority, thus making it an ideal choice for ensuring security and privacy in DTNs. Results show that the proposed approach guards against privacy attacks and delivers a high degree of anonymity even in the presence of compromised nodes in the network

Provenance based data integrity checking and verification in cloud environments

<div><p>Cloud computing is a recent tendency in IT that moves computing and data away from desktop and hand-held devices into large scale processing hubs and data centers respectively. It has been proposed as an effective solution for data outsourcing and on demand computing to control the rising cost of IT setups and management in enterprises. However, with Cloud platforms user’s data is moved into remotely located storages such that users lose control over their data. This unique feature of the Cloud is facing many security and privacy challenges which need to be clearly understood and resolved. One of the important concerns that needs to be addressed is to provide the proof of data integrity, i.e., correctness of the user’s data stored in the Cloud storage. The data in Clouds is physically not accessible to the users. Therefore, a mechanism is required where users can check if the integrity of their valuable data is maintained or compromised. For this purpose some methods are proposed like mirroring, checksumming and using third party auditors amongst others. However, these methods use extra storage space by maintaining multiple copies of data or the presence of a third party verifier is required. In this paper, we address the problem of proving data integrity in Cloud computing by proposing a scheme through which users are able to check the integrity of their data stored in Clouds. In addition, users can track the violation of data integrity if occurred. For this purpose, we utilize a relatively new concept in the Cloud computing called “Data Provenance”. Our scheme is capable to reduce the need of any third party services, additional hardware support and the replication of data items on client side for integrity checking.</p></div

Comparison of existing integrity schemes in Cloud.

<p>Comparison of existing integrity schemes in Cloud.</p

System details for evaluation.

<p>System details for evaluation.</p