Demographic and Socioeconomic Determinants of Lassa Fever in Edo State, Nigeria

Lassa fever is a viral hemorrhagic fever caused by the Lassa virus and associated with significant morbidity and mortality. Yearly outbreaks of the disease occur in Edo State, Nigeria. The purpose of this study was to examine the demographic and socioeconomic factors that can influence transmission of the disease. The Commission on Social Determinants of Health conceptual framework was used in this research study. This framework describes the relationship between structural and intermediary factors and how they determine health outcomes. To answer the research question of how demographic and socioeconomic factors influence Lassa fever transmission in Edo State, a cross-sectional study was designed. After IRB approval, a questionnaire was used to collect data from sampled residents in six selected Local Government Areas in Edo State. Using SPSS, the relationships between independent variables (demographic and socioeconomic factors) and Lassa fever transmission were tested with chi square and logistic regression. The key findings in this study were that urban residence, occupation, monthly household income, poor housing condition and ethnic group were significantly associated with Lassa fever transmission. Recommendations from these findings include the consideration of these factors in the design and implementation of strategies for the control of the disease by government and partner organizations. The findings of this study can contribute to social change by providing empirical evidence to enhance the targets of advocacy and risk communication for Lassa fever control

Microbial Analysis of Biomedical Wastes From Selected Health Facilities in Parts of Edo South and Its Public Health Implication

This study, aimed at the microbial analysis of biomedical waste (BMW) was carried out using 100 samples of 10 different BMW collected in duplicates from 5 busy primary healthcare centers (PHCs).The research findings showed a high prevalence of E.coli (39%) and S.aureus (32%) which were both statistically significant at P≤0.05, while the least isolated organisms were K. pnuemoniae (10%) and B. subtilis (4%) and were statistically not significant at P≥0.05. Samples from dressings and beddings were found to contain the highest microbial loadof 25 and 13 respectively while the least number of isolates were from expired cytotoxic drugs (2) and lancets (1).The biochemical tests showed the presence of Gram positive and negative organisms with record of both aerobic and anaerobic isolates from the BMW. The investigation revealed that BMW contains mixed bacterial community with some being pathogenic and pose a public health hazard to both health workers and other community members, therefore adequate treatment measures should be given to all BMW before disposal

Lassa Fever Infection among Healthcare Workers during the 2018 Outbreak in Nigeria

Introduction: Healthcare workers (HCWs) are potentially exposed to infection during viral hemorrhagic fever outbreaks. In the wake of 2018, Nigeria experienced an unprecedented surge in cases of Lassa fever (LF), which affected HCWs. To guide infection prevention and control (IPC) strategies in similar settings, we characterize HCWs' infection and describe the gaps in IPC standards and practices during the outbreak. Methods: Data was collected using a structured questionnaire, interview, and review of case notes of 21 HCW with laboratory-confirmed Lassa fever who were treated at the Irrua Specialist Teaching Hospital (ISTH) Irrua and the Alex-Ekwemen Federal Teaching Hospital, Abakaliki (AEFETHA), between 1st January and 27th May 2018. Information collected was the patients' socio-demographic characteristics, date of potential exposure and onset of illness, nature, and type of exposure, clinical features, outcome, use of personal protective equipment (PPE), and personnel IPC training and were analyzed using descriptive statistics with Microsoft Excel. Results: The study included 21 HCWs, and 12 (57.14%) were doctors. The case fatality rate was 23%. Nearly two-thirds (62%) of the HCWs could describe a likely procedure leading to their exposure and infection. Among 13 HCWs, 85% had multiple blood and body fluids exposure, while 15% had needle stick injury or scalpel cut. About one-fifth of the participants had received some IPC training. Conclusion: Limited IPC adherence and inappropriate risk assessment were identified as factors leading to Lassa fever exposure and infection among HCWs. There is an urgent need to provide IPC training for all HCWs and to ensure an adequate supply of IPC materials to all healthcare facilities as part of emergency preparedness, especially in LF endemic areas

Additional file 1 of Epidemiological description of and response to a large yellow fever outbreak in Edo state Nigeria, September 2018 - January 2019

Additional file 1: Supplementary Fig. 1. Suspected Yellow fever cases in Edo State by LGAs September 2018 – January 2019. Supplementary Fig. 2. Yellow fever attack rate by LGA in Edo State September 2018 - January 2019. Supplementary Fig. 3. Age-sex distribution of Yellow Fever cases in Edo State September 2018 - January 2019