Self-Reported Responses to Player Profile Questions Show Consistency with the Use of Complex Attentional Strategies by Expert Horseshoe Pitchers

The advantages on an external focus of attention have been demonstrated for a variety of sport tasks. The constrained action hypothesis (Wulf et al., 2001) argues that focusing externally on the movement effect results in the use of automated processes for movement control. In contrast, focusing internally in an attempt to control the movements of the body disrupts normally automated processes and degrades performance. Research on experts, however, suggests that they may adopt more complex attentional strategies. The present study provided a unique opportunity to examine expert horseshoe players’ attentional strategies as indicated by their self-reported responses to questions included in a National Horseshoe Pitchers Association (NHPA) player profile questionnaire. Responses submitted by 83 top NHPA players were examined to determine the frequency of references to the use of internal and external focus points and identify categories related to attentional strategies. Results indicated that the large majority of players reported using focus points that are consistent with an external focus of attention and that their thoughts corresponded to one or more categories related to technique, mental focus or concentration, general success, use of external focus cues, and emotional control. The findings are consistent with the view that experts may adopt complex attentional strategies that encompass both an external focus and thoughts about a variety of other performance related factors

Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant elimination reinforces functionality), which can be used to assess the extent of natural selection acting on an oligonucleotide motif or set of motifs predicted to have biological activity. As an application of this approach, we analyzed a set of 238 hexanucleotides previously predicted to have exonic splicing enhancer (ESE) activity in human exons using the relative enhancer and silencer classification by unanimous enrichment (RESCUE)-ESE method. Aligning the single nucleotide polymorphisms (SNPs) from the public human SNP database to the chimpanzee genome allowed inference of the direction of the mutations that created present-day SNPs. Analyzing the set of SNPs that overlap RESCUE-ESE hexamers, we conclude that nearly one-fifth of the mutations that disrupt predicted ESEs have been eliminated by natural selection (odds ratio = 0.82 ± 0.05). This selection is strongest for the predicted ESEs that are located near splice sites. Our results demonstrate a novel approach for quantifying the extent of natural selection acting on candidate functional motifs and also suggest certain features of mutations/SNPs, such as proximity to the splice site and disruption or alteration of predicted ESEs, that should be useful in identifying variants that might cause a biological phenotype

Correlation between microstructure and magnetotransport in organic semiconductor spin valve structures

We have studied magnetotransport in organic-inorganic hybrid multilayer junctions. In these devices, the organic semiconductor (OSC) Alq$_3$ (tris(8-hydroxyquinoline) aluminum) formed a spacer layer between ferromagnetic (FM) Co and Fe layers. The thickness of the Alq$_3$ layer was in the range of 50-150 nm. Positive magnetoresistance (MR) was observed at 4.2 K in a current perpendicular to plane geometry, and these effects persisted up to room temperature. The devices' microstructure was studied by X-ray reflectometry, Auger electron spectroscopy and polarized neutron reflectometry (PNR). The films show well-defined layers with modest average chemical roughness (3-5 nm) at the interface between the Alq$_3$ and the surrounding FM layers. Reflectometry shows that larger MR effects are associated with smaller FM/Alq$_3$ interface width (both chemical and magnetic) and a magnetically dead layer at the Alq$_3$/Fe interface. The PNR data also show that the Co layer, which was deposited on top of the Alq$_3$, adopts a multi-domain magnetic structure at low field and a perfect anti-parallel state is not obtained. The origins of the observed MR are discussed and attributed to spin coherent transport. A lower bound for the spin diffusion length in Alq$_3$ was estimated as $43 \pm 5$ nm at 80 K. However, the subtle correlations between microstructure and magnetotransport indicate the importance of interfacial effects in these systems.Comment: 21 pages, 11 figures and 2 table

A slot scheduling mechanism at congested airports which incorporates efficiency, fairness and airline preferences

Congestion is a problem at airports where capacity does not meet demand. At many such airports, airlines must request time slots for the purpose of landing or take off. Given the imbalance between demand and capacity, slot requests cannot always be scheduled as requested. The difference between the requested and allocated time slots is called displacement. Minimization of the total displacement is a key slot-scheduling objective and expresses the efficiency of the slot-scheduling process. Additionally, fairness has been proposed as a slot-scheduling criterion. Fairness relates to the allocation of the total schedule displacement among the various airlines. Single- and multiobjective models have been proposed for slot scheduling. However, currently the literature lacks models that incorporate the preferences of airlines regarding the allocation of displacement to their flights. This paper proposes a two-stage mechanism for the scheduling of slots at congested airports. The proposed mechanism considers efficiency and fairness objectives and incorporates the preferences of airlines in allocating the total displacement associated with the flights of each airline. The first stage of the mechanism constructs a reference schedule that is fair to the participating airlines. In the second stage, the airlines specify how the displacement allocated to them in the reference schedule should be distributed among their requests. The mechanism then adjusts the fair reference schedule to meet as many of these preferences as possible. The development and implementation of the proposed slot-scheduling mechanism is demonstrated using real data from a coordinated airport and simulated displacement preference data. The proposed slot-scheduling mechanism provides useful information to decision makers regarding the equity–efficiency trade-off and enhances the transparency and acceptability of the slot-scheduling outcome

Modelling and solving the airport slot-scheduling problem with multi-objective, multi-level considerations

In overly congested airports requests for landing and take-off slots are allocated according to the IATA World Scheduling Guidelines (WSG). A central concept of these guidelines is the prioritization of the satisfaction of the requested slots according to a hierarchy that recognizes historic usage rights of slots. A number of criteria have been proposed in the literature to optimize airport slot allocation decisions. Multi-objective programming models have been proposed to investigate the trade-offs of the slot allocation objectives for the same level of the slot hierarchy. However, the literature currently lacks models that can study in a systematic way the trade-offs among the scheduling objectives across all levels of the hierarchy and the airport schedule as a whole. To close the existing literature gap, we are proposing a new tri-objective slot allocation model (TOSAM) that considers total schedule displacement, maximum schedule displacement and demand-based fairness, and we introduce a multi-level, multi-objective algorithm to solve it. We are using real world slot request and airport capacity data to demonstrate the applicability of the proposed approach. Our computational results suggest that the systematic consideration of the interactions among the objectives of the different levels of the slot hierarchy, results to improved schedule-wide slot scheduling performance. In particular, we found that small sacrifices made for the attainment of the scheduling objectives of the upper echelons of the slot hierarchy, result in significant improvements of the schedule-wide objectives

A nonlinear Quasi-3D approach for the modeling of mufflers with perforated elements and sound-absorbing material

Increasing demands on the capabilities of engine thermo-�uid dynamic simulation and the ability to accurately predict both performance and acoustics have led to the development of several approaches, ranging from fully 3D to simpli�ed 1D models. e quasi-3D approach is proposed as a compromise between the time-demanding 3D CFD analysis and the fast 1D approach; it allows to model the acoustics of intake and exhaust system components, used in internal combustion engines, resorting to a 3D network of 0D cells. Due to its 3D nature, the model predicts high-order modes, improving the accuracy at high frequencies with respect to conventional plane-wave approaches. e conservation equations of mass and energy are solved at cell centers, whereas the momentum equation is applied to cell connections including speci�c source term to account for the of sound-absorbing materials and perforated elements. e quasi-3D approach has been validated by comparing the predicted transmission loss to measured data for a number of standard con�gurations typical of internal combustion engine exhaust systems: a reverse-�ow chamber and series chambers with perforates and resistive material

Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn

Analysis of lymphocyte cell lines revealed substantial differences in the expression of mRNA and microRNA (miRNA) among human populations. The extent of such population-associated differences in actual human tissues remains largely unexplored. The placenta is one of the few solid human tissues that can be collected in substantial numbers in a controlled manner, enabling quantitative analysis of transient biomolecules such as RNA transcripts. Here, we analyzed microRNA (miRNA) expression in human placental samples derived from 36 individuals representing four genetically distinct human populations: African Americans, European Americans, South Asians, and East Asians. All samples were collected at the same hospital following a unified protocol, thus minimizing potential biases that might influence the results