26 research outputs found
Proposed low-energy absolute calibration of nuclear recoils in a dual-phase noble element TPC using D-D neutron scattering kinematics
We propose a new technique for the calibration of nuclear recoils in large noble element dual-phase time projection chambers used to search for WIMP dark matter in the local galactic halo. This technique provides an measurement of the low-energy nuclear recoil response of the target media using the measured scattering angle between multiple neutron interactions within the detector volume. The low-energy reach and reduced systematics of this calibration have particular significance for the low-mass WIMP sensitivity of several leading dark matter experiments. Multiple strategies for improving this calibration technique are discussed, including the creation of a new type of quasi-monoenergetic 272 keV neutron source. We report results from a time-of-flight based measurement of the neutron energy spectrum produced by an Adelphi Technology, Inc. DD108 neutron generator, confirming its suitability for the proposed nuclear recoil calibration.Peer Reviewe
An Ultra-Low Background PMT for Liquid Xenon Detectors
Results are presented from radioactivity screening of two models of
photomultiplier tubes designed for use in current and future liquid xenon
experiments. The Hamamatsu 5.6 cm diameter R8778 PMT, used in the LUX dark
matter experiment, has yielded a positive detection of four common radioactive
isotopes: 238U, 232Th, 40K, and 60Co. Screening of LUX materials has rendered
backgrounds from other detector materials subdominant to the R8778
contribution. A prototype Hamamatsu 7.6 cm diameter R11410 MOD PMT has also
been screened, with benchmark isotope counts measured at <0.4 238U / <0.3 232Th
/ <8.3 40K / 2.0+-0.2 60Co mBq/PMT. This represents a large reduction, equal to
a change of \times 1/24 238U / \times 1/9 232Th / \times 1/8 40K per PMT,
between R8778 and R11410 MOD, concurrent with a doubling of the photocathode
surface area (4.5 cm to 6.4 cm diameter). 60Co measurements are comparable
between the PMTs, but can be significantly reduced in future R11410 MOD units
through further material selection. Assuming PMT activity equal to the measured
90% upper limits, Monte Carlo estimates indicate that replacement of R8778 PMTs
with R11410 MOD PMTs will change LUX PMT electron recoil background
contributions by a factor of \times1/25 after further material selection for
60Co reduction, and nuclear recoil backgrounds by a factor of \times 1/36. The
strong reduction in backgrounds below the measured R8778 levels makes the
R11410 MOD a very competitive technology for use in large-scale liquid xenon
detectors.Comment: v2 updated to include content after reviewer comments (Sep 2012
LUXSim: A Component-Centric Approach to Low-Background Simulations
Geant4 has been used throughout the nuclear and high-energy physics community
to simulate energy depositions in various detectors and materials. These
simulations have mostly been run with a source beam outside the detector. In
the case of low-background physics, however, a primary concern is the effect on
the detector from radioactivity inherent in the detector parts themselves. From
this standpoint, there is no single source or beam, but rather a collection of
sources with potentially complicated spatial extent. LUXSim is a simulation
framework used by the LUX collaboration that takes a component-centric approach
to event generation and recording. A new set of classes allows for multiple
radioactive sources to be set within any number of components at run time, with
the entire collection of sources handled within a single simulation run.
Various levels of information can also be recorded from the individual
components, with these record levels also being set at runtime. This
flexibility in both source generation and information recording is possible
without the need to recompile, reducing the complexity of code management and
the proliferation of versions. Within the code itself, casting geometry objects
within this new set of classes rather than as the default Geant4 classes
automatically extends this flexibility to every individual component. No
additional work is required on the part of the developer, reducing development
time and increasing confidence in the results. We describe the guiding
principles behind LUXSim, detail some of its unique classes and methods, and
give examples of usage.
* Corresponding author, [email protected]: 45 pages, 15 figure
Measurements of wavelength-dependent double photoelectron emission from single photons in VUV-sensitive photomultiplier tubes
Characterization of photomultiplier tubes with a realistic model through GPU-boosted simulation
Noninvasive Monitoring of Mantle Cell Lymphoma by Immunoglobulin Gene Next-Generation Sequencing in a Phase 2 Study of Sequential Chemoradioimmunotherapy Followed by Autologous Stem-Cell Rescue
Minimal residual disease (MRD) monitoring has been used to identify early molecular relapse and predict clinical relapse in mantle cell lymphoma (MCL). Few published data exist in MCL on the performance of next-generation sequencing–based assay of immunoglobulin gene rearrangements for MRD assessment.
In a prospective clinical trial (NCT01484093) with intensive induction chemotherapy and autologous stem-cell transplantation, posttreatment peripheral blood samples were collected from 16 MCL patients and analyzed with an earlier version of the Adaptive Biotechnologies MRD assay.
Of the 7 patients whose disease remained in remission, the MRD test remained negative in 5 (71%). Of the 9 patients who experienced relapse, the MRD test was positive at least 3 months before relapse in 6 patients (67%) and positive at the time of relapse in 1 patient (11%). All patients with at least 2 positive MRD tests experienced relapse.
The next-generation sequencing–based MRD assay identified early molecular relapse, and we observed more sensitivity in the cellular (circulating leukocytes) versus acellular (plasma cell-free DNA) compartment. This observation may be due to availability of tumor target or a limitation of the assay.
Limited information exists in mantle cell lymphoma (MCL) on the performance of next-generation sequencing–based assay of immunoglobulin gene rearrangements for minimal residual disease (MRD) assessment. Posttreatment peripheral blood samples were collected from 16 MCL patients and analyzed with the Adaptive Biotechnologies MRD assay, which identified early molecular relapse. We observed more sensitivity in the cellular versus acellular compartment