712 research outputs found
An empirical investigation on relationship between social capital and organizational commitment
This paper presents an empirical investigation to study the relationship between social capital and organizational commitment. The study considers the relationship between social capital with three components of organizational commitment; namely, affective commitment, continuous and normative commitment. The study has been applied among a sample of 292 regular employees who worked for an Iranian bank located in city of Tehran, Iran. The implementation of Pearson correlation has indicated that there were positive and meaningful relationships between social capital and affective commitment (r = 0.197, Sig. = 0.01), continuous (r = 0.308, Sig. = 0.01) and normative commitment (r = 0.423, Sig. = 0.01). In addition, the study has detected that women had more commitment on their organization than men did. The proposed study of this paper has also considered a regression model where organizational commitment is dependent variable and trust and communication are considered as independent variables. According to the results of regression analysis, an increase of one unit in trust and social capital communication will increase organizational commitment by 0.189 and 0.204, respectively
Strengthening mechanisms of graphene sheets in aluminium matrix nanocomposites
Uniform dispersion of SiC nanoparticles with a high propensity to agglomerate within a thixoformed aluminium matrix was attained using a graphene encapsulating approach. The analytical model devised in this study has demonstrated the significant role of shear lag and thermally activated dislocation mechanisms in strengthening aluminium metal matrix composites due to the exceptional negative thermal expansion coefficient of graphene sheets. This, in turn, triggers the pinning capacity of nano-sized rod-liked aluminium carbide, prompting strong interface bonding for SiC nanoparticles with the matrix, thereby enhancing tensile elongation
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Role of KASH domain lengths in the regulation of LINC complexes.
The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. For example, in Caenorhabditis elegans, SUN protein UNC-84 binds to two KASH proteins UNC-83 and ANC-1 to mediate nuclear migration and anchorage, respectively. In addition to distinct cytoplasmic domains, the luminal KASH domain also varies among KASH domain proteins of distinct functions. In this study, we combined in vivo C. elegans genetics and in silico molecular dynamics simulations to understand the relation between the length and amino acid composition of the luminal KASH domain, and the function of the SUN-KASH complex. We show that longer KASH domains can withstand and transfer higher forces and interact with the membrane through a conserved membrane proximal EEDY domain that is unique to longer KASH domains. In agreement with our models, our in vivo results show that swapping the KASH domains of ANC-1 and UNC-83, or shortening the KASH domain of ANC-1, both result in a nuclear anchorage defect in C. elegans
Magnetic Field Dependent Microwave Losses in Superconducting Niobium Microstrip Resonators
We describe an experimental protocol to characterize magnetic field dependent
microwave losses in superconducting niobium microstrip resonators. Our approach
provides a unified view that covers two well-known magnetic field dependent
loss mechanisms: quasiparticle generation and vortex motion. We find that
quasiparticle generation is the dominant loss mechanism for parallel magnetic
fields. For perpendicular fields, the dominant loss mechanism is vortex motion
or switches from quasiparticle generation to vortex motion, depending on
cooling procedures. In particular, we introduce a plot of the quality factor
versus the resonance frequency as a general method for identifying the dominant
loss mechanism. We calculate the expected resonance frequency and the quality
factor as a function of the magnetic field by modeling the complex resistivity.
Key parameters characterizing microwave loss are estimated from comparisons of
the observed and expected resonator properties. Based on these key parameters,
we find a niobium resonator whose thickness is similar to its penetration depth
is the best choice for X-band electron spin resonance applications. Finally, we
detect partial release of the Meissner current at the vortex penetration field,
suggesting that the interaction between vortices and the Meissner current near
the edges is essential to understand the magnetic field dependence of the
resonator properties
Corneal Confocal Microscopy Detects Small Fibre Neuropathy in Patients with Upper Gastrointestinal Cancer and Nerve Regeneration in Chemotherapy Induced Peripheral Neuropathy.
Published onlineThere are multiple neurological complications of cancer and its treatment. This study assessed the utility of the novel non-invasive ophthalmic technique of corneal confocal microscopy in identifying neuropathy in patients with upper gastrointestinal cancer before and after platinum based chemotherapy. In this study, 21 subjects with upper gastrointestinal (oesophageal or gastric) cancer and 21 healthy control subjects underwent assessment of neuropathy using the neuropathy disability score, quantitative sensory testing for vibration perception threshold, warm and cold sensation thresholds, cold and heat induced pain thresholds, nerve conduction studies and corneal confocal microscopy. Patients with gastro-oesophageal cancer had higher heat induced pain (P = 0.04) and warm sensation (P = 0.03) thresholds with a significantly reduced sural sensory (P<0.01) and peroneal motor (P<0.01) nerve conduction velocity, corneal nerve fibre density (CNFD), nerve branch density (CNBD) and nerve fibre length (CNFL) (P<0.0001). Furthermore, CNFD correlated significantly with the time from presentation with symptoms to commencing chemotherapy (r = -0.54, P = 0.02), and CNFL (r = -0.8, P<0.0001) and CNBD (r = 0.63, P = 0.003) were related to the severity of lymph node involvement. After the 3rd cycle of chemotherapy, there was no change in any measure of neuropathy, except for a significant increase in CNFL (P = 0.003). Corneal confocal microscopy detects a small fibre neuropathy in this cohort of patients with upper gastrointestinal cancer, which was related to disease severity. Furthermore, the increase in CNFL after the chemotherapy may indicate nerve regeneration
Dynamic Price Dispersion of Seasonal Goods in Bertrand–Edgeworth Competition
The primary distinguishing characteristics of various revenue management systems include fixed capacities, uniform products, and customers' sensitivity to pricing when making purchase decisions. Even with only two or three competitors, the competition remains intense. This study examines the sub-game perfect Nash equilibrium of price competition within an oligopoly market where goods are perishable assets. Each seller possesses a single unit of a non-replenishable good and competes by setting prices to sell their inventory over a finite sales period. Each period, buyers seek to purchase one unit of the good, and the number of buyers entering is random. All sellers' prices are visible to buyers, and there is no cost associated with searching for goods. Through stochastic dynamic programming methods, sellers' optimal responses can be determined by treating the competition as a one-time price-setting game, considering the remaining sales periods and the current demand pattern. Assuming a binary demand model, it is demonstrated that the duopoly model exhibits a unique Nash equilibrium. In addition, it is shown that the oligopoly model does not result in price dispersion based on a discussed metric. Moreover, when a generalized demand model is considered, the duopoly model features a unique Nash equilibrium with mixed strategies, whereas the oligopoly model exhibits a unique symmetric Nash equilibrium with mixed strategies
Small nerve fibre quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fibre density
OBJECTIVE: Quantitative assessment of small fiber damage is key to the early diagnosis and assessment of progression or regression of diabetic sensorimotor polyneuropathy (DSPN). Intraepidermal nerve fiber density (IENFD) is the current gold standard, but corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, has the potential to be a noninvasive and objective image biomarker for identifying small fiber damage. The purpose of this study was to determine the diagnostic performance of CCM and IENFD by using the current guidelines as the reference standard.
RESEARCH DESIGN AND METHODS: Eighty-nine subjects (26 control subjects and 63 patients with type 1 diabetes), with and without DSPN, underwent a detailed assessment of neuropathy, including CCM and skin biopsy.
RESULTS: Manual and automated corneal nerve fiber density (CNFD) (P < 0.0001), branch density (CNBD) (P < 0.0001) and length (CNFL) (P < 0.0001), and IENFD (P < 0.001) were significantly reduced in patients with diabetes with DSPN compared with control subjects. The area under the receiver operating characteristic curve for identifying DSPN was 0.82 for manual CNFD, 0.80 for automated CNFD, and 0.66 for IENFD, which did not differ significantly (P = 0.14).
CONCLUSIONS: This study shows comparable diagnostic efficiency between CCM and IENFD, providing further support for the clinical utility of CCM as a surrogate end point for DSPN
The Effect of Rearrangement of the Most Incompatible Particle on Increase of Convergence Speed of PSO
This article presents a new method for increasing the speed of Particle Swarm Optimization (PSO) method. The particle swarm is an optimization method that was inspired by collective movement of birds and fish looking for food. This method is composed of a group of particles: each particle tries to move in one direction that the best individual and best group of particles occur in that direction. Different articles tried to expand PSO so that global optimization is gained in less time. One of the problems of this model that occurs in most cases is falling of particles in local optimum. By finding the most incompatible particle and its rearrangement in the searching space, we increase convergence speed in some considered methods. Different tests of this method in standard searching space demonstrated that this method takes account of suitable function of increasing the convergece speed of particles.DOI:http://dx.doi.org/10.11591/ijece.v3i2.202
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