Inequalities in the Universal Right to Health

Child health inequalities violate children’s rights to optimal wellbeing. Different issues worldwide affect children’s physical and mental health as well as their development, influencing their future as adults. Inequities are avoidable inequalities. Despite improvements in the past two decades, the ambitious goals of global agendas have, for the most part, remained as expectations with regard to childhood rights, social justice, and health equity in practice. The concept of social determinants of health has become part of the common language in certain settings, but this is still too little to improve health in practice on a global scale, particularly for underprivileged subgroups of the community, as children and adolescents often are. Pediatric health professionals and their organizations are also responsible for guaranteeing children’s and adolescents’ right to health and better wellbeing, helping to reduce health inequalities

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Inequalities in the Universal Right to Health

Child health inequalities violate children’s rights to optimal wellbeing. Different issues worldwide affect children’s physical and mental health as well as their development, influencing their future as adults. Inequities are avoidable inequalities. Despite improvements in the past two decades, the ambitious goals of global agendas have, for the most part, remained as expectations with regard to childhood rights, social justice, and health equity in practice. The concept of social determinants of health has become part of the common language in certain settings, but this is still too little to improve health in practice on a global scale, particularly for underprivileged subgroups of the community, as children and adolescents often are. Pediatric health professionals and their organizations are also responsible for guaranteeing children’s and adolescents’ right to health and better wellbeing, helping to reduce health inequalities

Living conditions scoring system.

<p>Living conditions scoring system.</p

Survival curves.

<p>Owing to the great variability of the characteristics of the cohort (from age, to duration of disease, to disease stage at entry, to the different robustness of the socioeconomic markers), only a fully adjusted multivariable analysis of the whole cohort could provide a synthetic view of the determinants of the combined outcome end-point of the cohort as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153963#pone.0153963.t005" target="_blank">Table 5</a>.</p

The social profile of the cohort of 257 CKD paediatric patients.

<p>The social profile of the cohort of 257 CKD paediatric patients.</p

Socioeconomic factors as related to the cumulative outcome of mortality and lost to follow-up.

<p>Socioeconomic factors as related to the cumulative outcome of mortality and lost to follow-up.</p

Cox regression analysis.

<p>Cox regression analysis.</p

Profile of the cohort according to its outcomes.

<p>Profile of the cohort according to its outcomes.</p