Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serumlevels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of firstepisode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions.Male patients had lower levels of progesterone than controls

explorative study on the use of omalizumab in patients suffering from interstitial cystitis bladder pain syndrome

The aim of this study was to evaluate the efficacy of omalizumab in the treatment of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), evaluated by visual analogue score for pain and urgency- frequency, O'Leary-Sant IC symptom and problem index questionnaire, Pain Urgency Frequency questionnaire and Patient Global Assessment questionnaire. Four female patients with a diagnosis of IC/BPS were included in the study, with an age between 20 and 39 years. In the first patient the subjective final evaluation was of a marked improvement. The second patient had a moderate improvement of the subjective final evaluation. The third patient considered her overall clinical situation to have slightly improved after treatment. One 32-year-old patient, with multiple allergies, discontinued treatment after 3 months and could not complete the study due to side effects. Omalizumab was subcutaneously administered to patients with IC/PBS; it induced both a subjective and objective improvement of symptoms in 2 patients enrolled in the study

First-episode psychosis and migration in Italy (PEP-Ita migration): a study in the Italian mental health services

BACKGROUND: It has been frequently reported a higher incidence of psychotic disorders in immigrants than in native populations. There is, however, a lack of knowledge about risk factors which may explain this phenomenon. A better understanding of the causes of psychosis among first-generation migrants is highly needed, particularly in Italy, a country with a recent massive migration. METHODS/DESIGN: The "Italian study on first-episode psychosis and migration (PEP-Ita)" is a prospective observational study over a two-year period (1 January 2012-31 December 2013) which will be carried out in 11 Italian mental health centres. All participating centres will collect data about all new cases of migrants with first-episode psychosis. The general purpose ("core") of the PEP-Ita study is to explore the socio-demographic and clinical characteristics, and the pathways to care of a population of first-episode psychosis migrants in Italy. Secondary aims of the study will be: 1) to understand risk and protective factors for the development of psychotic disorders in migrants; 2) to evaluate the correlations between psychopathology of psychotic disorders in migrants and socio-demographic characteristics, migration history, life experiences; 3) to evaluate the clinical and social outcomes of first-episode psychoses in migrants. DISCUSSION: The results of the PEP-Ita study will allow a better understanding of risk factors for psychosis in first-generation migrants in Italy. Moreover, our results will contribute to the development of prevention programmes for psychosis and to the improvement of early intervention treatments for the migrant population in Italy

Aspetti epidemiologici della calcolosi di calcio in Italia: distribuzione dei fenotipi intermedi nella popolazione italiana

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Maintenance and energy optimization of lighting systems for the improvement of historic buildings. A case study

A proper lighting is vital to improve, from an artistic point of view, the volumes and the decorative surfaces of the architectural heritage considered valuable. When properly lighted monumental buildings can become, in the eye of those watching the panorama offered by the historic centre, an essential part of the city. Nowadays for the design planners dealing with the improvement of buildings, whose architectural design should be valorized, the real challenge is to combine the lighting artistic requirements with a scrupulous economic management in order to limit the energy demand and to respect the environment.This case study examines the lighting of the monumental façade and of the Cloister of St. Peter in Chains placed right in the Faculty of Engineering of Sapienza University of Rome. The site is characterized by the remarkable late Renaissance steps at the entrance and the imposing colonnade of the Cloister where, in the centre, there is a well thought to be a work by Michelangelo. The complex requires a type of lighting able to combine the necessities determined by its exertion from the Faculty with an architectural optimization. In order to reach such result some efficient sources of light, with high visual performances and a proper service life, were used

Maintenance and energy optimization of lighting systems for the improvement of historic buildings: A case study

Proper lighting is vital to improve, from an artistic point of view, the surface expanse and decorative detailing of architectural heritage buildings considered valuable. When properly lit, monumental buildings can become to onlookers an essential part of the city. Nowadays, for design planners dealing with the improvement of buildings, whose architectural design should be valorized, the real challenge is to combine the lighting artistic requirements with scrupulous economic management in order to limit the energy demand and to respect the environment. For these reasons, this case study examines the lighting of the monumental façade and the cloister of St. Peter in Chains situated in the Faculty of Engineering of Sapienza University of Rome. The present lighting installation, characterized by metal halides, compact fluorescent and halogen lamps, is compared with an alternative scenario presenting LED lamps and scenographic lighting of the monumental façade. Such comparison is based on the evaluation of the lighting levels for different visual tasks and on energy and maintenance issues; the first analysis was performed through the software DIALux Evo 4.0, whereas the second was performed using ecoCALC. This study leads to the conclusion that the lighting levels of the solution presenting LED lamps are better than those of the present solution, and they comply with current standards. Finally, the higher costs of LED lamp installations and the scenographic lighting of the monumental façade are balanced by lower maintenance costs, with a payback period of seven years

Pretherapeutic dosimetry in patients affected by metastatic thyroid cancer using I-124 PET/CT sequential scans for I-131 treatment planning

Purpose: This study evaluates the use of sequential 124I PET/CT for predicting absorbed doses to metastatic lesions in patients with differentiated thyroid cancer undergoing 131I therapy. Methods: From July 2011 until July 2013, 30 patients with metastatic differentiated thyroid cancer were enrolled. Each participant underwent PET/CT at 4, 24, 48, and 72 hours with 74 MBq of 124I. Blood samples and whole-body exposure measurements were obtained to calculate blood and red marrow doses. Activity concentrations and lesion volumes obtained from PET/CT were used to evaluate tumor doses with medical internal radiation dose formalism and spheres modeling. Mean administered 131I therapeutic dose was 5994 MBq (range, 1953–11,455 MBq). Results: 124I PET/CT demonstrated all lesions detected by posttherapy 131I whole-body scans. Mean dose rates for blood, red marrow, and lesions were as follows: 0.07 ± 0.02 mGy/MBq, 0.05 ± 0.02 mGy/MBq, and 46.5 ± 117 mGy/MBq, respectively. Despite the high level of thyroid-stimulating hormone and CT detectable lesions, 15 of 30 patients did not show any abnormal 124I uptake. Conclusions: The quantitative value of 124I PET/CT allows simple and accurate evaluation of lesion dosimetry following medical internal radiation dose formalism. Negative 124I PET/CT predicts absence of iodine avidity, potentially allowing avoidance of therapeutically ineffective 131I administration