53 research outputs found
Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms
<p>Abstract</p> <p>Background</p> <p>Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aimed to determine whether CP type IIIA/IIIB identified by magnifying NBI is effective for estimating the depth of invasion in early colorectal neoplasms.</p> <p>Methods</p> <p>A series of 127 consecutive patients with 130 colorectal lesions were evaluated from October 2005 to October 2007 at the National Cancer Center Hospital East, Chiba, Japan. Lesions were classified as CP type IIIA or type IIIB according to the NBI CP classification. Lesions were histopathologically evaluated. Inter and intraobserver variabilities were assessed by three colonoscopists experienced in NBI.</p> <p>Results</p> <p>There were 15 adenomas, 66 intramucosal cancers (pM) and 49 submucosal cancers (pSM): 16 pSM superficial (pSM1) and 33 pSM deep cancers (pSM2-3). Among lesions diagnosed as CP IIIA 86 out of 91 (94.5%) were adenomas, pM-ca, or pSM1; among lesions diagnosed as CP IIIB 28 out of 39 (72%) were pSM2-3. Sensitivity, specificity and diagnostic accuracy of the CP type III for differentiating pM-ca or pSM1 (<1000 μm) from pSM2-3 (≥1000 μm) were 84.8%, 88.7 % and 87.7%, respectively. Interobserver variability: κ = 0.68, 0.67, 0.72. Intraobserver agreement: κ = 0.79, 0.76, 0.75</p> <p>Conclusion</p> <p>Identification of CP type IIIA/IIIB by magnifying NBI is useful for estimating the depth of invasion of early colorectal neoplasms.</p
ヒト タンドウガン ニオケル アラタナ xenograft モデル ノ カクリツ ト トクチョウ
Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 3460, 2004.3.25Includes bibliographical referencesJoint authors: Hiroshi Kamma ... et a
Narrow-band imaging optical chromocolonoscopy: Advantages and limitations
Narrow-band imaging (NBI) is an innovative optical technology that modifies the center wavelength and bandwidth of an endoscope’s light into narrow-band illumination of 415 ± 30 nm. NBI markedly improves capillary pattern contrast and is an in vivo method for visualizing microvessel morphological changes in superficial neoplastic lesions. The scientific basis for NBI is that short wavelength light falls within the hemoglobin absorption band, thereby facilitating clearer visualization of vascular structures. Several studies have reported advantages and limitations of NBI colonoscopy in the colorectum. One difficulty in evaluating results, however, has been non-standardization of NBI systems (Sequential and non-sequential). Utilization of NBI technology has been increasing worldwide, but accurate pit pattern analysis and sufficient skill in magnifying colonoscopy are basic fundamentals required for proficiency in NBI diagnosis of colorectal lesions. Modern optical technology without proper image interpretation wastes resources, confuses untrained endoscopists and delays inter-institutional validation studies. Training in the principles of “optical image-enhanced endoscopy” is needed to close the gap between technological advancements and their clinical usefulness. Currently available evidence indicates that NBI constitutes an effective and reliable alternative to chromocolonoscopy for in vivo visualization of vascular structures, but further study assessing reproducibility and effectiveness in the colorectum is ongoing at various medical centers
Endoscopic treatments for early gastroesophageal lesions
Gastroesophageal (GEJ) carcinoma is well-recognized since the 1970s and has shown 2.5-fold increase in incidence since then. There still exists much controversy and ambiguity in the literature about the occurrence and recurrence of these lesions post-treatment. This has been attributed to the variability in the terms and definitions used in these junctional lesions. Despite this, great strides have been made in the treatment of early lesions decreasing morbidity and mortality from surgical treatment options. The current modalities involve ablation [like radiofrequency, cryo or argon plasma coagulation (APC)] and/or resection [endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD)] depending on the type and nature of lesion. These techniques are an effective tool demonstrating high rates of complete eradication of metaplasia or dysplasia (CE-IM/CE-D). It is crucial that the endoscopists are mindful about meticulous examination of the GEJ and Cardia as well as partake in appropriate surveillance post-endoscopic eradication. In addition, appropriate documentation of the location and type of lesion is also extremely important. This review aims to compare current endoscopic techniques in their efficacy, need for expertise and risk of complications when used in the treatment of early junctional lesions. Future studies and guideline recommendations to standardize definitions, diagnoses and post-treatment surveillance are needed
La faringe: examen de un área que con demasiada frecuencia se ignora durante endoscopia superior
7 páginasHead and neck cancer may be the most costly cancer to
treat in the United States.1 This is particularly noteworthy
for health care providers, their patients, and those paying
for health care services because of the high morbidity of
such cancers and the fact that only 48% of survivors return
to work.1 There are nearly 30,000 incident cases of oral
and pharyngeal cancer in the United States annually, with
approximately 8000 deaths as the survival rates have
improved little over the past 3 decades.2 Worldwide,
pharyngeal cancer accounts for 130,000 incident cases and
83,000 deaths each year.3,4 It is predominantly a cancer in
men who use tobacco and consume alcoholic beverages,
which are both identified as group 1 carcinogens.5El cáncer de cabeza y cuello puede ser el cáncer más costoso de tratar
tratar en los Estados Unidos.1 Esto es particularmente digno de mención
para los proveedores de atención médica, sus pacientes y quienes pagan
para los servicios de atención de salud debido a la alta morbilidad de
tales cánceres y el hecho de que sólo el 48% de los supervivientes regresan
trabajar.1 Hay casi 30.000 casos incidentes de abuso oral.
y cáncer de faringe en los Estados Unidos anualmente, con
aproximadamente 8000 muertes ya que las tasas de supervivencia han
ha mejorado poco en las últimas tres décadas.2 En todo el mundo,
El cáncer de faringe representa 130.000 casos incidentes y
83.000 muertes cada año.3,4 Es predominantemente un cáncer en
hombres que consumen tabaco y consumen bebidas alcohólicas,
ambos identificados como carcinógenos del grupo 1.
Infection, cancer and prevention: Report of the 19th International Symposium of the Foundation for Promotion of Cancer Research
El 19º Simposio Internacional de la Fundación para la Promoción de la Investigación del Cáncer, "Infección, cáncer y prevención", se celebró en Tokio del 21 al 23 de febrero de 2006. El simposio fue organizado por los Dres. Daizo Saito, Martin Blaser, Tadao Kakizoe, Kumao Toyoshima, Hiroshi Yoshikura, Toshiya Hirayama, Tadahito Kanda, Kunitada Shimotohno y Kensei Tobinai, con el Dr. Takashi Sugimura como asesor.‘Infection, Cancer and Prevention’, the Nineteenth International Symposium of the Foundation for Promotion of Cancer Research, was held in Tokyo on 21–23 February 2006. The symposium was organized by Drs Daizo Saito, Martin Blaser, Tadao Kakizoe, Kumao Toyoshima, Hiroshi Yoshikura, Toshiya Hirayama, Tadahito Kanda, Kunitada Shimotohno and Kensei Tobinai, with Dr Takashi Sugimura as advisor
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