Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms

<p>Abstract</p> <p>Background</p> <p>Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aimed to determine whether CP type IIIA/IIIB identified by magnifying NBI is effective for estimating the depth of invasion in early colorectal neoplasms.</p> <p>Methods</p> <p>A series of 127 consecutive patients with 130 colorectal lesions were evaluated from October 2005 to October 2007 at the National Cancer Center Hospital East, Chiba, Japan. Lesions were classified as CP type IIIA or type IIIB according to the NBI CP classification. Lesions were histopathologically evaluated. Inter and intraobserver variabilities were assessed by three colonoscopists experienced in NBI.</p> <p>Results</p> <p>There were 15 adenomas, 66 intramucosal cancers (pM) and 49 submucosal cancers (pSM): 16 pSM superficial (pSM1) and 33 pSM deep cancers (pSM2-3). Among lesions diagnosed as CP IIIA 86 out of 91 (94.5%) were adenomas, pM-ca, or pSM1; among lesions diagnosed as CP IIIB 28 out of 39 (72%) were pSM2-3. Sensitivity, specificity and diagnostic accuracy of the CP type III for differentiating pM-ca or pSM1 (<1000 μm) from pSM2-3 (≥1000 μm) were 84.8%, 88.7 % and 87.7%, respectively. Interobserver variability: κ = 0.68, 0.67, 0.72. Intraobserver agreement: κ = 0.79, 0.76, 0.75</p> <p>Conclusion</p> <p>Identification of CP type IIIA/IIIB by magnifying NBI is useful for estimating the depth of invasion of early colorectal neoplasms.</p

ヒト タンドウガン ニオケル アラタナ xenograft モデル ノ カクリツ ト トクチョウ

Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 3460, 2004.3.25Includes bibliographical referencesJoint authors: Hiroshi Kamma ... et a

Interview with Dr. David Allan Peura: a Gastroenterologist of Gastroenterologists and a Master or Masters

10 página

Narrow-band imaging optical chromocolonoscopy: Advantages and limitations

Narrow-band imaging (NBI) is an innovative optical technology that modifies the center wavelength and bandwidth of an endoscope’s light into narrow-band illumination of 415 ± 30 nm. NBI markedly improves capillary pattern contrast and is an in vivo method for visualizing microvessel morphological changes in superficial neoplastic lesions. The scientific basis for NBI is that short wavelength light falls within the hemoglobin absorption band, thereby facilitating clearer visualization of vascular structures. Several studies have reported advantages and limitations of NBI colonoscopy in the colorectum. One difficulty in evaluating results, however, has been non-standardization of NBI systems (Sequential and non-sequential). Utilization of NBI technology has been increasing worldwide, but accurate pit pattern analysis and sufficient skill in magnifying colonoscopy are basic fundamentals required for proficiency in NBI diagnosis of colorectal lesions. Modern optical technology without proper image interpretation wastes resources, confuses untrained endoscopists and delays inter-institutional validation studies. Training in the principles of “optical image-enhanced endoscopy” is needed to close the gap between technological advancements and their clinical usefulness. Currently available evidence indicates that NBI constitutes an effective and reliable alternative to chromocolonoscopy for in vivo visualization of vascular structures, but further study assessing reproducibility and effectiveness in the colorectum is ongoing at various medical centers

La faringe: examen de un área que con demasiada frecuencia se ignora durante endoscopia superior

7 páginasHead and neck cancer may be the most costly cancer to treat in the United States.1 This is particularly noteworthy for health care providers, their patients, and those paying for health care services because of the high morbidity of such cancers and the fact that only 48% of survivors return to work.1 There are nearly 30,000 incident cases of oral and pharyngeal cancer in the United States annually, with approximately 8000 deaths as the survival rates have improved little over the past 3 decades.2 Worldwide, pharyngeal cancer accounts for 130,000 incident cases and 83,000 deaths each year.3,4 It is predominantly a cancer in men who use tobacco and consume alcoholic beverages, which are both identified as group 1 carcinogens.5El cáncer de cabeza y cuello puede ser el cáncer más costoso de tratar tratar en los Estados Unidos.1 Esto es particularmente digno de mención para los proveedores de atención médica, sus pacientes y quienes pagan para los servicios de atención de salud debido a la alta morbilidad de tales cánceres y el hecho de que sólo el 48% de los supervivientes regresan trabajar.1 Hay casi 30.000 casos incidentes de abuso oral. y cáncer de faringe en los Estados Unidos anualmente, con aproximadamente 8000 muertes ya que las tasas de supervivencia han ha mejorado poco en las últimas tres décadas.2 En todo el mundo, El cáncer de faringe representa 130.000 casos incidentes y 83.000 muertes cada año.3,4 Es predominantemente un cáncer en hombres que consumen tabaco y consumen bebidas alcohólicas, ambos identificados como carcinógenos del grupo 1.

Infection, cancer and prevention: Report of the 19th International Symposium of the Foundation for Promotion of Cancer Research

El 19º Simposio Internacional de la Fundación para la Promoción de la Investigación del Cáncer, "Infección, cáncer y prevención", se celebró en Tokio del 21 al 23 de febrero de 2006. El simposio fue organizado por los Dres. Daizo Saito, Martin Blaser, Tadao Kakizoe, Kumao Toyoshima, Hiroshi Yoshikura, Toshiya Hirayama, Tadahito Kanda, Kunitada Shimotohno y Kensei Tobinai, con el Dr. Takashi Sugimura como asesor.‘Infection, Cancer and Prevention’, the Nineteenth International Symposium of the Foundation for Promotion of Cancer Research, was held in Tokyo on 21–23 February 2006. The symposium was organized by Drs Daizo Saito, Martin Blaser, Tadao Kakizoe, Kumao Toyoshima, Hiroshi Yoshikura, Toshiya Hirayama, Tadahito Kanda, Kunitada Shimotohno and Kensei Tobinai, with Dr Takashi Sugimura as advisor

Colonoscopy: its reason, indication and measurement of quality indicators. Just when a study reported that is not as good as it seems to be!

9 páginasLa colonoscopia total ha sido, es, y probablemente seguirá siendo el método más seguro y eficaz no solo para resecar los pólipos adenomatosos sino para diagnosticar y tratar (en estado temprano) el cáncer colorrectal (CCR). No obstante, un reciente estudio pone en entredicho la eficacia de la colonoscopia proponiendo que la relación colonoscopia-CCR está limitada primariamente a la disminución de muertes por CCR localizados en el lado izquierdo del colon. Esta revisión se enfoca a la luz de la actual evidencia científica en tres aspectos fundamentales de la colonoscopia: su razón, su indicación y la medición de su calidad. En el contexto de CCR, la colonoscopia de screening es aquella que se recomienda a individuos sin signos o síntomas de la enfermedad pero con la probabilidad de tener CCR. Existen razones justificadas y aprobadas para solicitar una prueba de screening. Para el CCR, la colonoscopia cumple a cabalidad con todos ellos