295 research outputs found
The slow death (or rebirth?) of extended star formation in green valley early-type galaxies
UV observations in the local universe have uncovered a population of early-type galaxies with UV flux consistent with low-level recent or ongoing star formation. Understanding the origin of such star formation remains an open issue. We present resolved UV-optical photometry of a sample of 19 Sloan Digital Sky Survey (SDSS) early-type galaxies at drawn from the sample originally selected by Salim & Rich to lie in the bluer part of the green valley in the UV-optical color-magnitude diagram as measured by the . Utilizing high-resolution far-UV imaging provides unique insight into the distribution of UV light in these galaxies, which we call "extended star-forming early-type galaxies" (ESF-ETGs) because of extended UV emission that is indicative of recent star formation. The UV-optical color profiles of all ESF-ETGs show red centers and blue outer parts. Their outer colors require the existence of a significant underlying population of older stars in the UV-bright regions. An analysis of stacked SDSS spectra reveals weak LINER-like emission in their centers. Using a cross-matched SDSS DR7/ GR6 catalog, we search for other green valley galaxies with similar properties to these ESF-ETGs and estimate that of dust-corrected green valley galaxies of similar stellar mass and UV-optical color are likely ESF-candidates, i.e., ESF-ETGs are not rare. Our results are consistent with star formation that is gradually declining in existing disks, i.e., the ESF-ETGs are evolving onto the red sequence for the first time, or with rejuvenated star formation due to accreted gas in older disks provided that the gas does not disrupt the structure of the galaxy and the resulting star formation is not too recent and bursty. ESF-ETGs may typify an important subpopulation of galaxies that can linger in the green valley for up to several Gyrs, based on their resemblance to nearby gas-rich green valley galaxies with low-level ongoing star formation
Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening
Contains fulltext :
35756.pdf (publisher's version ) (Open Access)CONTEXT: Long-term follow-up data on cognitive and motor functioning in adult patients with congenital hypothyroidism, diagnosed by neonatal screening, are scarce. Hence, it is still unclear whether the frequently reported cognitive and motor deficits observed during childhood persist in adulthood. OBJECTIVE: The objective of this study was to examine cognitive and motor functioning in young adults with congenital hypothyroidism, born in the first 2 yr after the introduction of the Dutch neonatal screening program. DESIGN/SETTING/PATIENTS: Seventy patients were tested (mean age, 21.5 yr); 49 of them were previously tested at 9.5 yr. The median age at the start of treatment was 28 d (range, 4-293 d). Congenital hypothyroidism was classified as severe, moderate, or mild, according to pretreatment T(4) concentrations. MAIN OUTCOME MEASUREMENT: The main outcome measurement was the influence of the severity of congenital hypothyroidism and age at which T(4) supplementation was started on cognitive and motor outcome. RESULTS: Patients, particularly those with severe congenital hypothyroidism, had significantly higher (i.e. worse) motor scores (total score, 7.8; ball skills, 2.0; balance, 4.1) compared with controls (total score, 3.2; ball skills, 0.7; balance, 1.1), and lower full-scale (95.8), verbal (96.4), and performance (95.6) intelligence quotient (IQ) scores than the normal population. No significant change in IQ from childhood to adulthood was found, and for the majority of patients, motor score classification remained the same. The severity of congenital hypothyroidism, but not the starting day of treatment, was correlated with IQ and motor scores. CONCLUSIONS: It is concluded that the severity of congenital hypothyroidism, but not the timing of treatment initiation, is an important factor determining long-term cognitive and motor outcome. Clearly, detrimental effects on developmental outcome in patients with congenital hypothyroidism persist over time
AChR deficiency due to ε-subunit mutations: Two common mutations in the Netherlands
Congenital myasthenic syndromes are a clinically and genetically heterogeneous group of hereditary disorders affecting neuromuscular transmission. We have identified mutations within the acetylcholine receptor (AChR) ε-subunit gene underlying congenital myasthenic syndromes in nine patients (seven kinships) of Dutch origin. Previously reported mutations ε1369delG and εR311Q were found to be common; ε1369delG was present on at least one allele in seven of the nine patients, and εR311Q in six. Phenotypes ranged from relatively mild ptosis and external ophthalmoplegia to generalized myasthenia. The common occurrence of εR311Q and ε1369delG suggests a possible founder for each of these mutations originating in North Western Europe, possibly in Holland. Knowledge of the ethnic or geographic origin within Europe of AChR deficiency patients can help in targeting genetic screening and it may be possible to provide a rapid genetic diagnosis for patients of Dutch origin by screening first for εR311Q and ε1369delG
Workshop: Praktijklessen uit de Krimpenerwaard Triade : adviezen voor de verdere ontwikkeling en toepassing van de Triade als methode voor locatiespecifieke ecologische risicobeoordeling van bodemverontreiniging
De Triade geldt als een geaccepteerd instrument om de effecten van bodemverontreiniging op het bodemecosysteem te meten. In dit rapport zijn adviezen verwoord voor de verdere ontwikkeling en toepassing van de Triade, als methode om ecologische risico's van bodemverontreiniging te bepalen. Zij zijn gebaseerd op de ervaringen uit het Krimpenerwaard project en de discussies gevoerd in de workshop "Praktijkervaringen met de Krimpenerwaard Triade" op 12 september 200
Attitudes toward health, healthcare, and eHealth of people with a low socioeconomic status: a community-based participatory approach
Health and self-regulatio
Observational Constraints on Chaplygin Quartessence: Background Results
We derive the constraints set by several experiments on the quartessence
Chaplygin model (QCM). In this scenario, a single fluid component drives the
Universe from a nonrelativistic matter-dominated phase to an accelerated
expansion phase behaving, first, like dark matter and in a more recent epoch
like dark energy. We consider current data from SNIa experiments, statistics of
gravitational lensing, FR IIb radio galaxies, and x-ray gas mass fraction in
galaxy clusters. We investigate the constraints from this data set on flat
Chaplygin quartessence cosmologies. The observables considered here are
dependent essentially on the background geometry, and not on the specific form
of the QCM fluctuations. We obtain the confidence region on the two parameters
of the model from a combined analysis of all the above tests. We find that the
best-fit occurs close to the CDM limit (). The standard
Chaplygin quartessence () is also allowed by the data, but only at
the level.Comment: Replaced to match the published version, references update
Effect of enzyme therapy and prognostic factors in 69 adults with Pompe disease: An open-label single-center study
Abstract. Background: Enzyme replacement therapy (ERT) in adults with Pompe disease, a progressive neuromuscular disorder, is of promising but variable efficacy. We investigated whether it alters the course of disease, and also identified potential prognostic factors. Methods. Patients in this open-label single-center study were treated biweekly with 20 mg/kg alglucosidase alfa. Muscle strength, muscle function, and pulmonary function were assessed every 3-6 months and analyzed using repeated-measures ANOVA. Results: Sixty-nine patients (median age 52.1 years) were followed for a median of 23 months. Muscle strength increased after start of ERT (manual muscle testing 1.4 percentage points per year (pp/y); hand-held dynamometry 4.0 pp/y; both p < 0.001). Forced vital capacity (FVC) remained stable when measured in upright, but declined in supine position (-1.1 pp/y; p = 0.03). Muscle function did not improve in all patients (quick motor function test 0.7 pp/y; p = 0.14), but increased significantly in wheelchair-independent patients and those with mild and moderate muscle weakness.Relative to the pre-treatment period (49 patients with 14 months pre-ERT and 22 months ERT median follow-up), ERT affected muscle strength positively (man
Post-Newtonian SPH calculations of binary neutron star coalescence. I. Method and first results
We present the first results from our Post-Newtonian (PN) Smoothed Particle
Hydrodynamics (SPH) code, which has been used to study the coalescence of
binary neutron star (NS) systems. The Lagrangian particle-based code
incorporates consistently all lowest-order (1PN) relativistic effects, as well
as gravitational radiation reaction, the lowest-order dissipative term in
general relativity. We test our code on sequences of single NS models of
varying compactness, and we discuss ways to make PN simulations more relevant
to realistic NS models. We also present a PN SPH relaxation procedure for
constructing equilibrium models of synchronized binaries, and we use these
equilibrium models as initial conditions for our dynamical calculations of
binary coalescence. Though unphysical, since tidal synchronization is not
expected in NS binaries, these initial conditions allow us to compare our PN
work with previous Newtonian results.
We compare calculations with and without 1PN effects, for NS with stiff
equations of state, modeled as polytropes with . We find that 1PN
effects can play a major role in the coalescence, accelerating the final
inspiral and causing a significant misalignment in the binary just prior to
final merging. In addition, the character of the gravitational wave signal is
altered dramatically, showing strong modulation of the exponentially decaying
waveform near the end of the merger. We also discuss briefly the implications
of our results for models of gamma-ray bursts at cosmological distances.Comment: RevTeX, 37 pages, 17 figures, to appear in Phys. Rev. D, minor
corrections onl
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
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