Narrowband, crystal-controlled biomedical telemetry system

Telemetry system utilizing miniature, single-channel, crystal-controlled transmitter is described suitable for biomedical applications. Receiver used in conjunction with transmitter is narrowband superheterodyne FM receiver with crystal control in both conversion stages

A long-range and long-life telemetry data-acquisition system for heart rate and multiple body temperatures from free-ranging animals

The system includes an implantable transmitter, external receiver-retransmitter collar, and a microprocessor-controlled demodulator. The size of the implant is suitable for animals with body weights of a few kilograms or more; further size reduction of the implant is possible. The ECG is sensed by electrodes designed for internal telemetry and to reduce movement artifacts. The R-wave characteristics are then specifically selected to trigger a short radio frequency pulse. Temperatures are sensed at desired locations by thermistors and then, based on a heartbeat counter, transmitted intermittently via pulse interval modulation. This modulation scheme includes first and last calibration intervals for a reference by ratios with the temperature intervals to achieve good accuracy even over long periods. Pulse duration and pulse sequencing are used to discriminate between heart rate and temperature pulses as well as RF interference

Code dependencies of pre-supernova evolution and nucleosynthesis in massive stars: Evolution to the end of core helium burning

Massive stars are key sources of radiative, kinetic and chemical feedback in the Universe. Grids of massive star models computed by different groups each using their own codes, input physics choices and numerical approximations, however, lead to inconsistent results for the same stars. We use three of these 1D codes – genec, kepler and mesa – to compute non-rotating stellar models of 15, 20 and 25 M⊙ and compare their nucleosynthesis. We follow the evolution from the main sequence until the end of core helium burning. The genec and kepler models hold physics assumptions used in large grids of published models. The mesa code was set up to use convective core overshooting such that the CO core masses are consistent with those obtained by genec. For all models, full nucleosynthesis is computed using the NuGrid post-processing tool mppnp. We find that the surface abundances predicted by the models are in reasonable agreement. In the helium core, the standard deviation of the elemental overproduction factors for Fe to Mo is less than 30 per cent – smaller than the impact of the present nuclear physics uncertainties. For our three initial masses, the three stellar evolution codes yield consistent results. Differences in key properties of the models, e.g. helium and CO core masses and the time spent as a red supergiant, are traced back to the treatment of convection and, to a lesser extent, mass loss. The mixing processes in stars remain the key uncertainty in stellar modelling. Better constrained prescriptions are thus necessary to improve the predictive power of stellar evolution models

Double Compact Objects III: Gravitational Wave Detection Rates

The unprecedented range of second-generation gravitational-wave (GW) observatories calls for refining the predictions of potential sources and detection rates. The coalescence of double compact objects (DCOs)---i.e., neutron star-neutron star (NS-NS), black hole-neutron star (BH-NS), and black hole-black hole (BH-BH) binary systems---is the most promising source of GWs for these detectors. We compute detection rates of coalescing DCOs in second-generation GW detectors using the latest models for their cosmological evolution, and implementing inspiral-merger-ringdown (IMR) gravitational waveform models in our signal-to-noise ratio calculations. We find that: (1) the inclusion of the merger/ringdown portion of the signal does not significantly affect rates for NS-NS and BH-NS systems, but it boosts rates by a factor $\sim 1.5$ for BH-BH systems; (2) in almost all of our models BH-BH systems yield by far the largest rates, followed by NS-NS and BH-NS systems, respectively, and (3) a majority of the detectable BH-BH systems were formed in the early Universe in low-metallicity environments. We make predictions for the distributions of detected binaries and discuss what the first GW detections will teach us about the astrophysics underlying binary formation and evolution.Comment: published in ApJ, 19 pages, 11 figure

Carbon-rich presolar grains from massive stars : subsolar ¹²C/¹³C and ¹⁴N/¹⁵N ratios and the mystery of ¹⁵N

Carbon-rich grains with isotopic anomalies compared to the Sun are found in primitive meteorites. They were made by stars, and carry the original stellar nucleosynthesis signature. Silicon carbide grains of Type X and C and low-density (LD) graphites condensed in the ejecta of core-collapse supernovae. We present a new set of models for the explosive He shell and compare them with the grains showing ¹²C/¹³C and ¹⁴N/¹⁵N ratios lower than solar. In the stellar progenitor H was ingested into the He shell and not fully destroyed before the explosion. Different explosion energies and H concentrations are considered. If the supernova shock hits the He-shell region with some H still present, the models can reproduce the C and N isotopic signatures in C-rich grains. Hot-CNO cycle isotopic signatures are obtained, including a large production of ¹³C and ¹⁵N. The short-lived radionuclides ²²Na and ²⁶Al are increased by orders of magnitude. The production of radiogenic ²²Ne from the decay of ²²Na in the He shell might solve the puzzle of the Ne-E(L) component in LD graphite grains. This scenario is attractive for the SiC grains of type AB with ¹⁴N/¹⁵N ratios lower than solar, and provides an alternative solution for SiC grains originally classified as nova grains. Finally, this process may contribute to the production of ¹⁴N and ¹⁵N in the Galaxy, helping to produce the ¹⁴N/¹⁵N ratio in the solar system

Black Hole - Neutron Star Mergers as Central Engines of Gamma-Ray Bursts

Hydrodynamic simulations of the merger of stellar mass black hole - neutron star binaries (BH/NS) are compared with mergers of binary neutron stars (NS/NS). The simulations are Newtonian, but take into account the emission and backreaction of gravitational waves. The use of a physical nuclear equation of state allows us to include the effects of neutrino emission. For low neutron star to black hole mass ratios the neutron star transfers mass to the black hole during a few cycles of orbital decay and subsequent widening before finally being disrupted, whereas for ratios near unity the neutron star is already distroyed during its first approach. A gas mass between about 0.3 and about 0.7 solar masses is left in an accretion torus around the black hole and radiates neutrinos at a luminosity of several 10^{53} erg/s during an estimated accretion time scale of about 0.1 s. The emitted neutrinos and antineutrinos annihilate into electron-positron pairs with efficiencies of 1-3% percent and rates of up to 2*10^{52} erg/s, thus depositing an energy of up to 10^{51} erg above the poles of the black hole in a region which contains less than 10^{-5} solar masses of baryonic matter. This could allow for relativistic expansion with Lorentz factors around 100 and is sufficient to explain apparent burst luminosities of up to several 10^{53} erg/s for burst durations of approximately 0.1-1 s, if the gamma emission is collimated in two moderately focussed jets in a fraction of about 1/100-1/10 of the sky.Comment: 8 pages, LaTex, 4 postscript figures, 2 tables. ApJ Letters, accepted; revised and shortened version, Fig. 2 change

Helium Star/Black Hole Mergers: a New Gamma-Ray Burst Model

We present a model for gamma-ray bursts (GRB's) in which a stellar mass black hole acquires a massive accretion disk by merging with the helium core of its red giant companion. The black hole enters the helium core after it, or its neutron star progenitor, first experiences a common envelope phase that carries it inwards through the hydrogen envelope. Accretion of the last several solar masses of helium occurs on a time scale of roughly a minute and provides a neutrino luminosity of approximately 10^51 - 10^52 erg/s. Neutrino annihilation, 0.01% to 0.1% efficient, along the rotational axis then gives a baryon loaded fireball of electron-positron pairs and radiation (about 10$^{50}$ erg total) whose beaming and relativistic interaction with circumstellar material makes the GRB (e.g., Rees & Meszaros 1992). The useful energy can be greatly increased if energy can be extracted from the rotational energy of the black hole by magnetic interaction with the disk. Such events should occur at a rate comparable to that of merging neutron stars and black hole neutron star pairs and may be responsible for long complex GRB's, but not short hard ones.Comment: 11 pages total, 2 Figures - altered and revised for ApJ letters, accepte

Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes.

OBJECTIVE: Evaluate relative clinical effectiveness of treatment options for type 2 diabetes mellitus (T2DM) using a statistical model of real-world evidence within UK general practitioner practices (GPP), to quantify the opportunities for diabetes care performance improvement. METHOD: From the National Diabetes Audit in 2015-2016 and 2016-2017, GPP target glycaemic control (TGC-%HbA1c ≤58 mmol/mol) and higher glycaemic risk (HGR -%HbA1c results >86 mmol/mol) outcomes were linked using multivariate linear regression to prescribing, demographics and practice service indicators. This was carried out both cross-sectionally (XS) (within year) and longitudinally (Lo) (across years) on 35 indicators. Standardised β coefficients were used to show relative level of impact of each factor. Improvement opportunity was calculated as impact on TGC & HGR numbers. RESULTS: Values from 6525 GPP with 2.7 million T2DM individuals were included. The cross-sectional model accounted for up to 28% TGC variance and 35% HGR variance, and the longitudinal model accounted for up to 9% TGC and 17% HGR variance. Practice service indicators including % achieving routine checks/blood pressure/cholesterol control targets were positively correlated, while demographic indicators including % younger age/social deprivation/white ethnicity were negatively correlated. The β values for selected molecules are shown as (increased TGC; decreased HGR), canagliflozin (XS 0.07;0.145/Lo 0.04;0.07), metformin (XS 0.12;0.04/Lo -;-), sitagliptin (XS 0.06;0.02/Lo 0.10;0.06), empagliflozin (XS-;0.07/Lo 0.09;0.07), dapagliflozin (XS -;0.04/Lo -;0.4), sulphonylurea (XS -0.18;-0.12/Lo-;-) and insulin (XS-0.14;0.02/ Lo-0.09;-). Moving all GPP prescribing and interventions to the equivalent of the top performing decile of GPP could result in total patients in TGC increasing from 1.90 million to 2.14 million, and total HGR falling from 191 000 to 123 000. CONCLUSIONS: GPP using more legacy therapies such as sulphonylurea/insulin demonstrate poorer outcomes, while those applying holistic patient management/use of newer molecules demonstrate improved glycaemic outcomes. If all GPP moved service levels/prescribing to those of the top decile, both TGC/HGR could be substantially improved