Reclassification of the intermediate group classified according to heartscore taking in considertaion individual genetic predisposition to coronary artery disease

PosterIntroduction: Cardiovascular risk stratification has included traditional cardiovascular risk factors (TRF) including tobacco, cholesterol and blood pressure adjusted to age and sex. The utility of genetic risk scores (GRS) as predictors of cardiovascular risk remains inconclusive. Objective: We intended to evaluate the ability of a multilocus GRS within the intermediate risk subgroup, defined by the European Heart score, to add predictive power for the association with coronary artery arterial disease (CAD). Methods: After applying European SCORE (ES) stratification to a total population of 2703 Portuguese individuals, 639 individuals with 59.0 ± 4.3 years were considered to be at intermediate risk subgroup (2 Results: GRS was an independent predictor for CAD (OR=2.411; pinfo:eu-repo/semantics/publishedVersio

Total Accumulative Losses during the Fermentation of Pioneiro Grass (\u3cem\u3ePennisetum purpureum\u3c/em\u3e Schumach) Silages with Addition of Whole Plant Maize and Maize Grain

Pioneiro grass (Pennisetum purpureum Schumach) has gained importance in silage production mainly due to its robust habit, perenniality and high yield capacity, although its typically high moisture content may influence negatively its potential for ensiled conservation. High moisture content at the time of ensilage has resulted in increased losses by gases and effluents (Balsalobre et al. 2001, Nussio 2005). Despite these losses, the high yields of tropical forages still justifies their use and study as roughage and silage in ruminant nutrition. Although tropical forages present an interesting alternative for conservation, maize silage still has widespread use across different systems because of its set of favorable natural characteristics for fermentation resulting in production of high quality silage (Anaya-Ortega et al. 2009). An experiment was conducted to evaluate the individual and combined effect of maize and Pioneiro grass on the total losses of the silages

Effects of multi-walled carbon nanotube materials on Ruditapes philippinarum under climate changes: the case of salinity shifts

The toxicity of carbon nanotubes (CNTs) is closely related to their physico-chemical characteristics as well as the physico-chemical parameters of the media where CNTs are dispersed. In a climate change scenario, changes in seawater salinity are becoming a topic of concern particularly in estuarine and coastal areas. Nevertheless, to our knowledge no information is available on how salinity shifts may alter the sensitivity (in terms of biochemical responses) of bivalves when exposed to different CNTs. For this reason, a laboratory experiment was performed exposing the Manila clam Ruditapes philippinarum, one of the most dominant bivalves of the estuarine and coastal lagoon environments, for 28 days to unfunctionalized multi-walled carbon nanotube MWCNTs (Nf-MWCNTs) and carboxylated MWCNTs (f-MWCNTs), maintained at control salinity (28) and low salinity 21. Concentration-dependent toxicity was demonstrated in individuals exposed to both MWCNT materials and under both salinities, generating alterations of energy reserves and metabolism, oxidative status and neurotoxicity compared to non-contaminated clams. Moreover, our results showed greater toxic impacts induced in clams exposed to f-MWCNTs compared to Nf-MWCNTs. In the present study it was also demonstrated how salinity shifts altered the toxicity of both MWCNT materials as well as the sensitivity of R. philippinarum exposed to these contaminates in terms of clam metabolism, oxidative status and neurotoxicity.publishe

The influence of Climate Change on the fate and behavior of different carbon nanotubes materials and implication to estuarine invertebrates

The widespread use of Carbon nanotubes (CNTs) has been increasing exponentially, leading to a significant potential release into the environment. Nevertheless, the toxic effects of CNTs in natural aquatic systems are related to their ability to interact with abiotic compounds. Considering that salinity variations are one of the main challenges in the environment and thus may influence the behavior and toxicity of CNTs, a laboratory experiment was performed exposing the tube-building polychaete Diopatra neapolitana (Delle Chiaje 1841) for 28 days to pristine multi-walled carbon nanotube (MWCNTs) and carboxylated MWCNTs, maintained at control salinity 28 and low salinity 21. An innovative approach based on thermogravimetric analysis (TGA) was adopted for the first time to assess the presence of MWCNTs aggregates in the organisms. Both CNTs generated toxic impacts in terms of regenerative capacity, energy reserves and metabolic capacity as well as oxidative and neuro status, however greater toxic impacts were observed in polychaetes exposed to carboxylated MWCNTs. Moreover, both CNTs maintained under control salinity (28) generated higher toxic impacts in the polychaetes compared to individuals maintained under low salinity (21), indicating that exposed polychaetes tend to be more sensitive to the alteration induced by salinity variations on the chemical behavior of both MWCNTs in comparison to salt stress.publishe