2,055 research outputs found
The Power of Empowerment:Predictors and Benefits of Shared Leadership in Organizations
Leadership plays an essential part in creating competitive advantage and well-beingamong employees. One way in which formal leaders can deal with the variety ofresponsibilities that comes with their role is to share their responsibilities with teammembers (i.e., shared leadership). Although there is abundant literature on how highquality peer leadership benefits team effectiveness (TE) and well-being, there is only limitedevidence about the underpinning mechanisms of these relationships and how the formalleader can support this process. To address this lacuna, we conducted an online surveystudy with 146 employees from various organizations. The results suggest that anempowering leadership style of the formal leader is associated with higher perceived peerleadership quality (PLQ) on four different leadership roles (i.e., task, motivational, social,and external leader). In addition, formal leaders who empower their team members arealso perceived as better leaders themselves. Moreover, the improved PLQ was in turnpositively related to TE and work satisfaction, while being negatively related to burnout.In line with the social identity approach, we found that team identification mediated theserelationships. Thus, high-quality peer leaders succeeded in creating a shared sense of“us” in the team, and this team identification in turn generated all the positive outcomes.To conclude, by sharing their lead and empowering the peer leaders in their team, formalleaders are key drivers of the team’s effectiveness, while also enhancing team members’health and well-being
Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells.
In order to study the inhibitory effect of various reverse transcriptase inhibitors (RTIs) on cell-free HIV, we adapted a recently described in vitro system, based on co-cultures of dendritic cells and resting CD4 T cells, modelling early target cells during sexual transmission. The compounds tested included the second-generation non-nucleoside RTI (NNRTI) TMC-120 (R147681, dapivirine) and TMC-125 (R165335, travertine), as well as the reference nucleoside RTI AZT (zidovudine), the nucleotide RTI PMPA (tenofovir) and the NNRTI UC-781. The virus strains included the reference strain HIV-1Ba-L and six primary isolates, representative of the HIV-1 group M pandemic. They all display the non-syncytium-inducing and CCR5 receptor-using (NSI/R5) phenotype, important in transmission. Cell-free virus was immobilized on a poly-L-lysine (PLL)-treated microwell plate and incubated with compound for 1 h. Afterwards, the compound was thoroughly washed away; target cells were added and cultured for 2 weeks, followed by an extended culture with highly susceptible mitogen-activated T cells. Viral production in the cultures was measured on supernatant with HIV antigen ELISA. Negative results were confirmed by showing absence of proviral DNA in the cells. TMC-120 and TMC-125 inhibited replication of HIV-1Ba-L with average EC50 values of 38 nM and 117 nM, respectively, whereas the EC50 of UC-781 was 517 nM. Complete suppression of virus and provirus was observed at compound concentrations of 100, 300 and 1000 nM, respectively. Inhibition of all primary isolates followed the same pattern as HIV-1Ba-L. In contrast, pre-treating the virus with the nucleotide RTI PMPA and AZT failed to inhibit infection even at a concentration of 100000 nM. These data clearly suggest that NNRTIs inactivate RT enzymatic activity of different viral clades (predominant in the epidemic) and might be proposed for further testing as a sterilizing microbicide worldwide
Tempering Transnational Advocacy?:The Effect of Repression and Regulatory Restriction on Transnational NGO Collaborations
This paper examines through qualitative study the effect of government regulatory restriction and repression on non-governmental organizations (NGOs) engaging in transnational advocacy. The focus is on NGO’s advocacy activities, in the realm of human rights, environment, labor and development in particular, using illustrations from Bangladesh and Zambia. It finds that next to some NGOs disbanding and moving towards service activities, many NGOs shift in terms of substantive advocacy and form of organizational collaboration. To continue cross-border interactions with their foreign partners, many NGOs adjust to circumvent or compensate for restrictions and repression. Because of this, transnational advocacy can be said to continue, but repression and restrictions have significant substantive and organizational effects for the collaborations studied, and cross-border NGO collaborations in our sample are increasingly fragile and their advocacy more tempered
Leading from the Centre: A Comprehensive Examination of the Relationship between Central Playing Positions and Leadership in Sport
This is the final version of the article. Available from Public Library of Science via the DOI in this record.RESEARCH AIMS: The present article provides a comprehensive examination of the relationship between playing position and leadership in sport. More particularly, it explores links between leadership and a player's interactional centrality-defined as the degree to which their playing position provides opportunities for interaction with other team members. This article examines this relationship across different leadership roles, team sex, and performance levels. RESULTS: Study 1 (N = 4443) shows that athlete leaders (and the task and motivational leader in particular) are more likely than other team members to occupy interactionally central positions in a team. Players with high interactional centrality were also perceived to be better leaders than those with low interactional centrality. Study 2 (N = 308) established this link for leadership in general, while Study 3 (N = 267) and Study 4 (N = 776) revealed that the same was true for task, motivational, and external leadership. This relationship is attenuated in sports where an interactionally central position confers limited interactional advantages. In other words, the observed patterns were strongest in sports that are played on a large field with relatively fixed positions (e.g., soccer), while being weaker in sports that are played on a smaller field where players switch positions dynamically (e.g., basketball, ice hockey). Beyond this, the pattern is broadly consistent across different sports, different sexes, and different levels of skill. CONCLUSIONS: The observed patterns are consistent with the idea that positions that are interactionally central afford players greater opportunities to do leadership-either through communication or through action. Significantly too, they also provide a basis for them to be seen to do leadership by others on their team. Thus while it is often stated that "leadership is an action, not a position," it is nevertheless the case that, when it comes to performing that action, some positions are more advantageous than others.This research was supported by a grant from Internal Funds KU Leuven, awarded to Katrien Fransen
Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure.
Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide. In erythrocytes, ceramide formation leads to exposure of the removal signal phosphatidylserine (PS), creating a potential link between SMase activity and anemia of inflammation. Therefore, we studied the effects of SMase on various pathophysiologically relevant parameters of erythrocyte homeostasis. Time-lapse confocal microscopy revealed a SMase-induced transition from the discoid to a spherical shape, followed by PS exposure, and finally loss of cytoplasmic content. Also, SMase treatment resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization, including microdomain formation. Furthermore, we observed increases in membrane fragility, vesiculation and invagination, and large protein clusters. These changes were associated with enhanced erythrocyte retention in a spleen-mimicking model. Erythrocyte storage under blood bank conditions and during physiological aging increased the sensitivity to SMase. A low SMase activity already induced morphological and structural changes, demonstrating the potential of SMase to disturb erythrocyte homeostasis. Our analyses provide a comprehensive picture in which ceramide-induced changes in membrane microdomain organization disrupt the membrane-cytoskeleton interaction and membrane integrity, leading to vesiculation, reduced deformability, and finally loss of erythrocyte content. Understanding these processes is highly relevant for understanding anemia during chronic inflammation, especially in critically ill patients receiving blood transfusions
Evolution of E2 transition strength in deformed hafnium isotopes from new measurements on Hf, Hf, and Hf
The available data for E2 transition strengths in the region between
neutron-deficient Hf and Pt isotopes are far from complete. More and precise
data are needed to enhance the picture of structure evolution in this region
and to test state-of-the-art nuclear models. In a simple model, the maximum
collectivity is expected at the middle of the major shell. However, for actual
nuclei, this picture may no longer be the case, and one should use a more
realistic nuclear-structure model. We address this point by studying the
spectroscopy of Hf. We remeasure the 2^+_1 half-lives of 172,174,176Hf, for
which there is some disagreement in the literature. The main goal is to
measure, for the first time, the half-lives of higher-lying states of the
rotational band. The new results are compared to a theoretical calculation for
absolute transition strengths. The half-lives were measured using \gamma-\gamma
and conversion-electron-\gamma delayed coincidences with the fast timing
method. For the determination of half-lives in the picosecond region, the
generalized centroid difference method was applied. For the theoretical
calculation of the spectroscopic properties, the interacting boson model is
employed, whose Hamiltonian is determined based on microscopic energy-density
functional calculations. The measured 2^+_1 half-lives disagree with results
from earlier \gamma-\gamma fast timing measurements, but are in agreement with
data from Coulomb excitation experiments and other methods. Half-lives of the
4^+_1 and 6^+_1 states were measured, as well as a lower limit for the 8^+_1
states. We show the importance of the mass-dependence of effective boson charge
in the description of E2 transition rates in chains of nuclei. It encourages
further studies of the microscopic origin of this mass dependence. New data on
transition rates in nuclei from neighboring isotopic chains could support these
studies.Comment: 16 pages, 16 figures, 7 tables; Abstract shortened due to character
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