Patient-Specific Method of Generating Parametric Maps of Patlak K(i) without Blood Sampling or Metabolite Correction: A Feasibility Study.

Currently, kinetic analyses using dynamic positron emission tomography (PET) experience very limited use despite their potential for improving quantitative accuracy in several clinical and research applications. For targeted volume applications, such as radiation treatment planning, treatment monitoring, and cerebral metabolic studies, the key to implementation of these methods is the determination of an arterial input function, which can include time-consuming analysis of blood samples for metabolite correction. Targeted kinetic applications would become practical for the clinic if blood sampling and metabolite correction could be avoided. To this end, we developed a novel method (Patlak-P) of generating parametric maps that is identical to Patlak K(i) (within a global scalar multiple) but does not require the determination of the arterial input function or metabolite correction. In this initial study, we show that Patlak-P (a) mimics Patlak K(i) images in terms of visual assessment and target-to-background (TB) ratios of regions of elevated uptake, (b) has higher visual contrast and (generally) better image quality than SUV, and (c) may have an important role in improving radiotherapy planning, therapy monitoring, and neurometabolism studies

Multiple Scalp Lesions in a Patient with Keratitis, Ichthyosis and Deafness Syndrome Mimicking Metastatic Squamous Cell Carcinoma on 18F-FDG PET/CT.

We report the case of a 17-year-old girl with keratitis, ichthyosis, and deafness (KID) syndrome. As a complication of her KID syndrome she developed squamous cell carcinoma at the left index finger. Additional clinical features were multiple soft tissue lesions over the scalp mimicking metastatic disease on 18F-FDG PET/CT. To our knowledge, this is the first case report about the uptake pattern of KID syndrome associated skin lesions on whole body PET/CT with 18F-FDG

PROBLEMS OF INCREASE IN THE WORLDVIEW VALUES YOUTH PROFESSIONAL ACTIVITIES

The article discusses the need for the development of one of the directions of quasilifikatsionnogo growth of teachers professional educational organizations. It is represented as the creation and improvement of organic to contemporary period efficient technologies familiarizing students to the social and cultural values. Author's attention drawn to meaningful for self- learning and the development of society value professional work discusses the problem of familiarizing students to this value through the creation of pedagogical conditions for the realization of its significance.В статье рассматривается необходимость развития одного из направлений квалификационного роста преподавателей профессиональных образовательных организаций. Оно представлено как создание и совершенствование органичных для современного периода технологий эффективного приобщения обучающихся к социокультурным ценностям. Внимание автора обращено на значимую для самореализации обучающихся и для развития общества ценность профессиональной деятельности. Обсуждается проблема приобщения обучающихся к этой ценности посредством создания педагогических условий для осознании ее значимости

Axiological aspect formation professional-moral culture of student

This article discusses one of the areas of moral development students of higher education institutions is to familiarize them with the polyvariant nature of domestic moral culture and understanding of the importance to individuals and society of its value. Particular attention is drawn to the consideration of moral values of traditional culture and the need for educating the axiological aspects of interaction between the subjects of the educational process for the formation of the professional responsibility of students professional responsibility, traditional moral cultureВ статье рассматривается одно из направлений нравственного развития студентов высших образовательных организаций, заключающееся в ознакомлении их с поливариантным характером отечественной нравственной культуры и пониманием ими значимости для личности и общества ее ценности. Особое внимание обращается на рассмотрение ценности традиционной нравственной культуры и на необходимость разработки аксиологического аспекта воспитывающего взаимодействия субъектов образовательного процесса для формирования профессиональной ответственности обучающихс

Approximation of holomorphic mappings on strongly pseudoconvex domains

Let D be a relatively compact strongly pseudoconvex domain in a Stein manifold, and let Y be a complex manifold. We prove that the set A(D,Y), consisting of all continuous maps from the closure of D to Y which are holomorphic in D, is a complex Banach manifold. When D is the unit disc in C (or any other topologically trivial strongly pseudoconvex domain in a Stein manifold), A(D,Y) is locally modeled on the Banach space A(D,C^n)=A(D)^n with n=dim Y. Analogous results hold for maps which are holomorphic in D and of class C^r up to the boundary for any positive integer r. We also establish the Oka property for sections of continuous or smooth fiber bundles over the closure of D which are holomorphic over D and whose fiber enjoys the Convex approximation property. The main analytic technique used in the paper is a method of gluing holomorphic sprays over Cartan pairs in Stein manifolds, with control up to the boundary, which was developed in our paper "Holomorphic curves in complex manifolds" (Duke Math. J. 139 (2007), no. 2, 203--253)

Screening for Medullary Thyroid Cancer in France: A National Effort

Screening for medullary thyroid cancer (MTC) in France is based on a protocol that has been widely distributed nationally. A network of coordinators utilizing a common questionnaire provides for an effective national screening program. Calcitonin stimulation procedures are systematically used for all first-degree relatives of MTC patients. Pathological studies utilize special immunopathologic techniques. Genealogic information is obtained on all index cases, and blood specimens are collected for establishing permanent cell lines. The data collected are used not only to establish the diagnosis of the hereditary or sporadic form of the disease but also to expand the screening as appropriate. This common protocol has benefited patients and their families by improving early detection of cases, increasing the number of families available for follow-up, and improving the prognosis of this cancer. Studies on these families have contributed significantly to the localization of the multiple endocrine neoplasia type 2 gene