A study of the Pine Portage Gold Prespect, Kenora district, Ontario

The Pine Portage gold prospect is located in Kirkup Township approximately 12 kilometers east of Kenora, Ontario. The mine site is within the Wabigoon Subprovince of the Superior Province of the Precambrian Shield. The area is characterized by belts of metavolcanics in the amphibolite metamorphic facies that have been intruded by granitic bodies. Reconnaissance mapping indicates three rock types present in the study area: amphibolite, granodiorite, and vein material. The amphibolite is composed of amphibole, plagioclase, chlorite, and clinozoisite. The granodiorite is composed of plagioclase, alkali feldspar, quartz, biotite, and epidote. The vein material is predominantly quartz-carbonate and contains altered schist, pyrite, and minor amounts of galena, sphalerite, tellurium, silver, and gold. The vein material occupies a sheared fissure and can be further divided into quartz-carbonate material regularly bounded by the headwall and a thin clay zone, quartz-carbonate material with sheared and altered schist, and brecciated amphibolite bounded by an irregular footwall. The quartz and pyrite of the vein show evidence of brecciation with calcite filling the resulting fractures. This is thought to indicate deformation and shear of an original fissure filled with quartz and pyrite. Calcite and possibly sulfide materials, tellurium, silver, and gold were emplaced following the deformation. This epigenetic, sheared fissure vein is thought to be the result of wallrock alteration and lateral secretion. The vein is proposed to be a redistribution of the host rock chemistry with the introduced volatiles CO2, H2O, and S. Meteoric water may be the source of these volatiles. Mafic bodies that lie to the southwest of Pine Portage could be a source of trace gold that is released by alteration. Elements released by alteration migrate to and along the shear zone and become concentrated in suitable host structures where they recombine with introduced elements in dilatent areas. Exploration concentrated on the alteration zones, the dilatent structures, and near the mafic bodies could prove fruitful

Low incidence of toxoplasma infection during pregnancy and in newborns in Sweden

To estimate the burden of disease due to congenital toxoplasmosis in Sweden the incidence of primary infections during pregnancy and birth prevalence of congenital toxoplasmosis in 40978 children born in two regions in Sweden was determined. Women possibly infected during pregnancy were identified based on: 1, detection of specific IgG based on neonatal screening of the phenylketonuria (PKU) card blood spot followed by retrospective testing of stored prenatal samples to detect women who acquired infection during pregnancy and follow up of their children to 12 months; 2, detection of specific IgM on the PKU blood spot. The birth prevalence of congenital toxoplasmosis was 0·73/10000 (95% CI 0·15–2·14) (3/40978). The incidence of primary infection during pregnancy was 5·1/10000 (95% CI 2·6–8·9) susceptible pregnant women. The seroprevalence in the southern part was 25·7% and in the Stockholm area 14·0%. The incidence of infection during pregnancy was low, as the birth prevalence of congenital toxoplasmosis. Neonatal screening warrants consideration in view of the low cost and feasibility

Late preterm birth has direct and indirect effects on infant gut microbiota development during the first six months of life

Aim: Preterm infants display aberrant gut microbial colonisation. We investigated whether the differences in gut microbiota between late preterm and full-term infants results from prematurity or external exposures.Methods: This study comprised 43 late preterm infants (34(0/7)-36(6/7)) and 75 full-term infants based on faecal samples collected following birth and at two to four weeks and six months of age. We assessed clinically relevant bacteria using quantitative polymerase chain reaction. Logistic regression analyses were performed to determine whether the observed differences in gut microbiota were attributable to prematurity or perinatal exposure.Results: The prevalence of bifidobacteria differed in the intestinal microbiota of the fullterm and late preterm neonates. Differences in the presence of specific species were detected at the age of six months, although the microbiota alterations were most prominent following delivery. As well as prematurity, the mode of birth, intrapartum and neonatal antibiotic exposure, and the duration of breastfeeding had an additional impact on gut microbiota development.Conclusion: The gut microbiota composition was significantly different between late preterm and full-term infants at least six months after birth. Antibiotic exposure was common in late preterm infants and modulated gut colonisation, but preterm birth also affected gut microbiota development independently

Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non‐type b strains

Introduction of a conjugated vaccine against encapsulated Haemophilus influenzae type b (Hib) has led to a dramatic reduction of invasive Hib disease. However, an increasing incidence of invasive disease by H. influenzae non‐type b has recently been reported. Non‐type b strains have been suggested to be opportunists in an invasive context, but information on clinical consequences and related medical conditions is scarce. In this retrospective study, all H. influenzae isolates ( n  =   410) from blood and cerebrospinal fluid in three metropolitan Swedish regions between 1997 and 2009 from a population of approximately 3 million individuals were identified. All available isolates were serotyped by PCR ( n  =   250). We observed a statistically significant increase in the incidence of invasive H. influenzae disease, ascribed to non‐typeable H. influenzae (NTHi) and encapsulated strains type f (Hif) in mainly individuals >60 years of age. The medical reports from a subset of 136 cases of invasive Haemophilus disease revealed that 48% of invasive NTHi cases and 59% of invasive Hif cases, respectively, met the criteria of severe sepsis or septic shock according to the ACCP/SCCM classification of sepsis grading. One‐fifth of invasive NTHi cases and more than one‐third of invasive Hif cases were admitted to intensive care units. Only 37% of patients with invasive non‐type b disease had evidence of immunocompromise, of which conditions related to impaired humoral immunity was the most common. The clinical burden of invasive non‐type b H. influenzae disease, measured as days of hospitalization/100 000 individuals at risk and year, increased significantly throughout the study period.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87052/1/j.1469-0691.2010.03417.x.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/87052/2/CLM_3417_sm_FigS1.pd

Cytotoxicity, in Vivo Skin Irritation and Acute Systemic Toxicity of the Mesoporous Magnesium Carbonate Upsalite ®

Abstract Upsalite ® is a mesoporous magnesium carbonate synthesized without using surfactants and therefore highly attractive from environmental and production economy points of view. The material has recently been suggested as drug delivery vehicle and as topical bacteriostatic agent. In order to continue exploring these and other bio-related applications of the material, primary biocompatibility studies are needed. Herein we present the first in vivo acute systemic toxicity and skin irritation analyses as well as in vitro cytotoxicity evaluations of Upsalite ® . The material was found to be non-toxic for human dermal fibroblasts cells up to a concentration of 1000 µg/ml and 48 h exposure in contrast to the mesoporous silica material SBA-15, used as reference, which significantly affected cell viability at particle concentration of 500 and 1000 µg/ml after the same exposure time. Topical application of Upsalite ® resulted in negligible cutaneous reactions in a rabbit skin irritation model and no evidence of significant systemic toxicity was found when saline extracts of Upsalite ® were injected in mice. Injection of sesame oil extract, however, resulted in transient weight loss, most likely due to injection of particles, and not toxic leachables. The presented results form the basis for future development of Upsalite ® and similar mesoporous materials in biomedical applications and further toxicity as well as biocompatibility studies should be directed towards specific areas of use

Анализ репродуктивного здоровья женщин с проявлениями вульвовагинального кандидоза, ассоциированного с герпетической инфекцией

РЕПРОДУКТИВНОСТИ АНАЛИЗЖЕНСКИЕ БОЛЕЗНИ И ОСЛОЖНЕНИЯ БЕРЕМЕННОСТИЖЕНСКИХ ПОЛОВЫХ ОРГАНОВ БОЛЕЗНИ И ОСЛОЖНЕНИЯ БЕРЕМЕННОСТИКОМОРБИДНОСТЬСОПУТСТВУЮЩИЕ БОЛЕЗНИКАНДИДОЗ ВУЛЬВОВАГИНАЛЬНЫЙВУЛЬВОВАГИНИТ МИКОТИЧЕСКИЙМОЛОЧНИЦА ВЛАГАЛИЩАМОНИЛИАЗ ВУЛЬВОВАГИНАЛЬНЫЙHERPESVIRIDAE ИНФЕКЦИИГЕРПЕСГЕРПЕСВИРУСНЫЕ ИНФЕКЦИ

Gender differences in Parkinson's disease: A clinical perspective

Available data indicate that there are gender differences in many features of Parkinson's disease (PD). Precise identification of the gender differences is important to tailor treatment, predict outcomes, and meet other individual and social needs in women and men with PD. The aim of this study was to review the available clinical data on gender differences in PD. Original articles and meta‐analyses published between 1990 and 2016 systematically exploring gender differences in PD were reviewed. There is slight male preponderance in incidence and prevalence of PD. PD starts earlier in men. Women tend to be more prone to develop tremor‐dominant PD but are less rigid than men. Motor improvement after deep brain stimulation is equal in both sexes, but women tend to show better improvement in activities of daily living. Furthermore, women with PD show better results on tests for general cognitive abilities, outperform men in verbal cognitive tasks, show more pain symptoms, and score higher on depression scales. It seems, however, that the differences in cognition, mood, and pain perception are not disease specific as similar gender differences can be found in healthy subjects and in other neurological conditions. Despite PD being the most frequently studied movement disorder, studies investigating gender differences in PD are still scarce with most of the studies being cross‐sectional. Good‐quality, prospective, longitudinal studies analyzing gender differences in PD and comparing them to matched healthy controls are needed in order to properly address the issues of gender differences in PD

Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts

BACKGROUND: The magnitude of the association between Helicobacter pylori and incidence of gastric cancer is unclear. H pylori infection and the circulating antibody response can be lost with development of cancer; thus retrospective studies are subject to bias resulting from classifi- cation of cases as H pylori negative when they were infected in the past. AIMS: To combine data from all case control studies nested within prospective cohorts to assess more reliably the relative risk of gastric cancer associated with H pylori infection.To investigate variation in relative risk by age, sex, cancer type and subsite, and interval between blood sampling and cancer diagnosis. METHODS: Studies were eligible if blood samples for H pylori serology were collected before diagnosis of gastric cancer in cases. Identified published studies and two unpublished studies were included. Individual subject data were obtained for each. Matched odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the association between H pylori and gastric cancer. RESULTS: Twelve studies with 1228 gastric cancer cases were considered. The association with H pylori was restricted to noncardia cancers (OR 3.0; 95% CI 2.3–3.8) and was stronger when blood samples for H pylori serology were collected 10+ years before cancer diagnosis (5.9; 3.4–10.3). H pylori infection was not associated with an altered overall risk of cardia cancer (1.0; 0.7–1.4). CONCLUSIONS: These results suggest that 5.9 is the best estimate of the relative risk of non-cardia cancer associated with H pylori infection and that H pylori does not increase the risk of cardia cancer. They also support the idea that when H pylori status is assessed close to cancer diagnosis, the magnitude of the non-cardia association may be underestimated