27,113 research outputs found
Recharge unit provides for optimum recharging of battery cells
Percent recharge unit permits each cell of a rechargeable battery to be charged to a preset capacity of the cell. The unit automatically monitors and controls a rechargeable battery subjected to charge-discharge cycling tests
Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response.
BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue. We used microarray analysis to determine which genes, pathways and networks were significantly altered using a rat model of TBI. Adult rats received a unilateral controlled cortical impact (CCI) and were sacrificed 24 h post-injury. The ipsilateral hemi-brain tissue at the site of the injury, the corresponding contralateral hemi-brain tissue, and naïve (control) brain tissue were used for microarray analysis. Ingenuity Pathway Analysis (IPA) software was used to identify molecular pathways and networks that were associated with the altered gene expression in brain tissues following TBI.ResultsInspection of the top fifteen biological functions in IPA associated with TBI in the ipsilateral tissues revealed that all had an inflammatory component. IPA analysis also indicated that inflammatory genes were altered on the contralateral side, but many of the genes were inversely expressed compared to the ipsilateral side. The contralateral gene expression pattern suggests a remote anti-inflammatory molecular response. We created a network of the inversely expressed common (i.e., same gene changed on both sides of the brain) inflammatory response (IR) genes and those IR genes included in pathways and networks identified by IPA that changed on only one side. We ranked the genes by the number of direct connections each had in the network, creating a gene interaction hierarchy (GIH). Two well characterized signaling pathways, toll-like receptor/NF-kappaB signaling and JAK/STAT signaling, were prominent in our GIH.ConclusionsBioinformatic analysis of microarray data following TBI identified key molecular pathways and networks associated with neural injury following TBI. The GIH created here provides a starting point for investigating therapeutic targets in a ranked order that is somewhat different than what has been presented previously. In addition to being a vehicle for identifying potential targets for post-TBI therapeutic strategies, our findings can also provide a context for evaluating the potential of therapeutic agents currently in development
Quantum Inequalities on the Energy Density in Static Robertson-Walker Spacetimes
Quantum inequality restrictions on the stress-energy tensor for negative
energy are developed for three and four-dimensional static spacetimes. We
derive a general inequality in terms of a sum of mode functions which
constrains the magnitude and duration of negative energy seen by an observer at
rest in a static spacetime. This inequality is evaluated explicitly for a
minimally coupled scalar field in three and four-dimensional static
Robertson-Walker universes. In the limit of vanishing curvature, the flat
spacetime inequalities are recovered. More generally, these inequalities
contain the effects of spacetime curvature. In the limit of short sampling
times, they take the flat space form plus subdominant curvature-dependent
corrections.Comment: 18 pages, plain LATEX, with 3 figures, uses eps
Bounds on negative energy densities in flat spacetime
We generalise results of Ford and Roman which place lower bounds -- known as
quantum inequalities -- on the renormalised energy density of a quantum field
averaged against a choice of sampling function. Ford and Roman derived their
results for a specific non-compactly supported sampling function; here we use a
different argument to obtain quantum inequalities for a class of smooth, even
and non-negative sampling functions which are either compactly supported or
decay rapidly at infinity. Our results hold in -dimensional Minkowski space
() for the free real scalar field of mass . We discuss various
features of our bounds in 2 and 4 dimensions. In particular, for massless field
theory in 2-dimensional Minkowski space, we show that our quantum inequality is
weaker than Flanagan's optimal bound by a factor of 3/2.Comment: REVTeX, 13 pages and 2 figures. Minor typos corrected, one reference
adde
Quantum Inequalities and Singular Energy Densities
There has been much recent work on quantum inequalities to constrain negative
energy. These are uncertainty principle-type restrictions on the magnitude and
duration of negative energy densities or fluxes. We consider several examples
of apparent failures of the quantum inequalities, which involve passage of an
observer through regions where the negative energy density becomes singular. We
argue that this type of situation requires one to formulate quantum
inequalities using sampling functions with compact support. We discuss such
inequalities, and argue that they remain valid even in the presence of singular
energy densities.Comment: 18 pages, LaTex, 2 figures, uses eps
Quantum inequalities in two dimensional curved spacetimes
We generalize a result of Vollick constraining the possible behaviors of the
renormalized expected stress-energy tensor of a free massless scalar field in
two dimensional spacetimes that are globally conformal to Minkowski spacetime.
Vollick derived a lower bound for the energy density measured by a static
observer in a static spacetime, averaged with respect to the observers proper
time by integrating against a smearing function. Here we extend the result to
arbitrary curves in non-static spacetimes. The proof, like Vollick's proof, is
based on conformal transformations and the use of our earlier optimal bound in
flat Minkowski spacetime. The existence of such a quantum inequality was
previously established by Fewster.Comment: revtex 4, 5 pages, no figures, submitted to Phys. Rev. D. Minor
correction
Possible evidence of a spontaneous spin-polarization in mesoscopic 2D electron systems
We have experimentally studied the non-equilibrium transport in low-density
clean 2D electron systems at mesoscopic length scales. At zero magnetic field
(B), a double-peak structure in the non-linear conductance was observed close
to the Fermi energy in the localized regime. From the behavior of these peaks
at non-zero B, we could associate them to the opposite spin states of the
system, indicating a spontaneous spin polarization at B = 0. Detailed
temperature and disorder dependence of the structure shows that such a
splitting is a ground state property of the low-density 2D systems.Comment: 7 pages, 5 figure
Casimir Force between a Dielectric Sphere and a Wall: A Model for Amplification of Vacuum Fluctuations
The interaction between a polarizable particle and a reflecting wall is
examined. A macroscopic approach is adopted in which the averaged force is
computed from the Maxwell stress tensor. The particular case of a perfectly
reflecting wall and a sphere with a dielectric function given by the Drude
model is examined in detail. It is found that the force can be expressed as the
sum of a monotonically decaying function of position and of an oscillatory
piece. At large separations, the oscillatory piece is the dominant
contribution, and is much larger than the Casimir-Polder interaction that
arises in the limit that the sphere is a perfect conductor. It is argued that
this enhancement of the force can be interpreted in terms of the frequency
spectrum of vacuum fluctuations. In the limit of a perfectly conducting sphere,
there are cancellations between different parts of the spectrum which no longer
occur as completely in the case of a sphere with frequency dependent
polarizability. Estimates of the magnitude of the oscillatory component of the
force suggest that it may be large enough to be observable.Comment: 18pp, LaTex, 7 figures, uses epsf. Several minor errors corrected,
additional comments added in the final two sections, and references update
Reply to Comment on "Completely positive quantum dissipation"
This is the reply to a Comment by R. F. O'Connell (Phys. Rev. Lett. 87 (2001)
028901) on a paper written by the author (B. Vacchini, ``Completely positive
quantum dissipation'', Phys.Rev.Lett. 84 (2000) 1374, arXiv:quant-ph/0002094).Comment: 2 pages, revtex, no figure
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