Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica (CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis and immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy

Exposição corporal do cliente no atendimento das necessidades básicas em UTI: incidentes críticos relatados por enfermeiras Exposición corporal de pacientes en la atención a las necesidades básicas en UTI: los incidentes críticos relatados por enfermeros Physical exposure of clients in care for basic needs at an ICU: critical incidents reported by nurses

Objetivou-se identificar e analisar situações envolvendo a exposição corporal e invasão da privacidade do cliente, inerentes à assistência em UTI. A população consistiu em 15 enfermeiras de UTIs para adultos, em Maringá-PR. Empregou-se a Técnica do Incidente Crítico (TIC), obtendo-se 30 relatos, 15 positivos e 15 negativos, extraindo-se 22 incidentes críticos positivos e 30 negativos. Esses foram compilados em 6 categorias, optando-se por apresentar e discutir a categoria Necessidades básicas. Os comportamentos da equipe de saúde constituíram 5 categorias e dos clientes 3. As conseqüências para a equipe de saúde e para os clientes compuseram 4 categorias. Verificou-se melhor preparo da enfermagem para contornar problemas relacionados ao atendimento dessas necessidades, que equipe e clientes manifestam os mesmos sentimentos, que os aspectos que garantem a qualidade da assistência são proteção da intimidade, respeito, confiança e orientação, e que desproteção da intimidade do cliente prejudica a qualidade da assistência.<br>La finalidad de esta investigación fue identificar y analizar las situaciones que implicaban la exposición corporal y la invasión de la privacidad del cliente, inherentes a la atención en la UTI. La población consistió en 15 enfermeros de UTIs de atención al adulto en Maringá-PR, Brasil. Fue utilizada la Técnica del Incidente Crítico (TIC), resultando en 30 informes, 15 positivos y 15 negativos, extrayéndose 22 incidentes críticos positivos y 30 negativos. Estos fueron agrupados en 6 categorías, optándose por la presentación y discusión de la categoría necesidades básicas. Los comportamientos del equipo de la salud se agruparon en 5 categorías y aquellos de los clientes en 3. Las consecuencias para el equipo de la salud y los clientes fueron agrupadas en 4 categorías. Verificamos que el equipo de enfermería está mejor preparado para esquivar los problemas relacionados a la atención de estas necesidades, que el equipo y los clientes manifiestan los mismos sentimientos, que los aspectos que garantizan la calidad de la atención son protección de la intimidad del cliente, respecto, confianza y orientación, y que desprotección de la intimidad del cliente perjudica la calidad de la atención.<br>This study aimed to identify and analyze situations involving the physical exposure and invasion of clients' privacy, which are inherent to ICU care. The population consisted of 15 adult ICU nurses in Maringá-PR, Brazil. The Critical Incident Technique was used (CIT), resulting in 30 reports, 15 of which were positive and 15 negative. From these, 22 positive and 30 negative critical incidents were extracted. These were compiled in 6 categories. We chose to present and to discuss the category Basic needs. The health team's behavior constituted 5 categories and the clients' behavior 3. Consequences for health team and clients corresponded to 4 categories. The results revealed that the nursing team is better prepared to handle problems related to care for basic needs; that team and clients disclose the same feelings; that privacy protection, respect, confidence and guidance guarantee the quality of care and that not protecting clients' intimacy impaired care quality

Tumor microenvironment participates in metastasis of pancreatic cancer

Abstract Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. These components can facilitate desmoplasia and immunosuppression in primary and metastatic sites or can promote metastasis by stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, and pre-metastatic niche formation. Some molecules participate in both microenvironment formation and metastasis. In this review, we focus on the mechanisms of pancreatic cancer microenvironment formation and discuss how the pancreatic cancer microenvironment participates in metastasis, representing a potential target for combination therapy to enhance overall survival