Structural, Metabolic, and Functional Brain Abnormalities as a Result of Prenatal Exposure to Drugs of Abuse: Evidence from Neuroimaging

Prenatal exposure to alcohol and stimulants negatively affects the developing trajectory of the central nervous system in many ways. Recent advances in neuroimaging methods have allowed researchers to study the structural, metabolic, and functional abnormalities resulting from prenatal exposure to drugs of abuse in living human subjects. Here we review the neuroimaging literature of prenatal exposure to alcohol, cocaine, and methamphetamine. Neuroimaging studies of prenatal alcohol exposure have reported differences in the structure and metabolism of many brain systems, including in frontal, parietal, and temporal regions, in the cerebellum and basal ganglia, as well as in the white matter tracts that connect these brain regions. Functional imaging studies have identified significant differences in brain activation related to various cognitive domains as a result of prenatal alcohol exposure. The published literature of prenatal exposure to cocaine and methamphetamine is much smaller, but evidence is beginning to emerge suggesting that exposure to stimulant drugs in utero may be particularly toxic to dopamine-rich basal ganglia regions. Although the interpretation of such findings is somewhat limited by the problem of polysubstance abuse and by the difficulty of obtaining precise exposure histories in retrospective studies, such investigations provide important insights into the effects of drugs of abuse on the structure, function, and metabolism of the developing human brain. These insights may ultimately help clinicians develop better diagnostic tools and devise appropriate therapeutic interventions to improve the condition of children with prenatal exposure to drugs of abuse

Doctor can I buy a new kidney? I've heard it isn't forbidden: what is the role of the nephrologist when dealing with a patient who wants to buy a kidney?

Organ trafficking is officially banned in several countries and by the main Nephrology Societies. However, this practice is widespread and is allowed or tolerated in many countries, hence, in the absence of a universal law, the caregiver may be asked for advice, placing him/her in a difficult balance between legal aspects, moral principles and ethical judgments. In spite of the Istanbul declaration, which is a widely shared position statement against organ trafficking, the controversy on mercenary organ donation is still open and some experts argue against taking a negative stance. In the absence of clear evidence showing the clinical disadvantages of mercenary transplantation compared to chronic dialysis, self-determination of the patient (and, with several caveats, of the donor) may conflict with other ethical principles, first of all non-maleficence. The present paper was drawn up with the participation of the students, as part of the ethics course at our medical school. It discusses the situation in which the physician acts as a counselor for the patient in the way of a sort of “reverse” informed consent, in which the patient asks advice regarding a complex personal decision, and includes a peculiar application of the four principles (beneficence, non-maleficence, justice and autonomy) to the donor and recipient parties

Local variations of metamorphic record from compositionally heterogeneous rocks (Cima di Gagnone, Central Alps): Inferences on exhumation processes of (U)HP–HT rocks

The record of metamorphic conditions is commonly highly heterogeneous in spatially close rocks of different composition and rheology. The well-studied Cima di Gagnone area in the Central Alps represents such an example, as relatively small, 1– to 100 s-meter scale, ultrahigh–pressure and high–temperature ultramafic lenses are enveloped within amphibolite–facies metasediments. We present new field observations, microstructural and petrological analyses, and thermodynamic modelling results on these metasediments, showing that these rocks generally experienced medium pressure and medium temperature conditions of 1.0–1.2 GPa and 640–700 °C, followed by a retrograde stage around 0.6–0.8 GPa and 600–675 °C. However, a few samples from the immediate proximity of the ultramafic lenses record significantly higher P–T conditions of 1.3–1.7 GPa and 750–850 °C, approaching the high pressure and high temperature conditions of the ultramafic bodies (1.5–3.1 GPa, 650–850 °C). Mineral/bulk chemistry changes during growth of new mineral phases hint to local melt/fluid interaction (i.e., metasomatism) between metasediments and ultramafics during the high temperature deformation. Preliminary U-Pb LA–ICP–MS dating suggests that zircon grains from the metasomatic reaction zone have been fully re–equilibrated during the early stage of Alpine exhumation (~36 Ma), while the large part of the metasediments records only pre–Alpine ages. We finally recast these new data into the regional P–T–t–D paths and discuss the consequences of these findings for understanding the exhumation processes of HP rocks. We found different local equilibria (ΔP up to 2 GPa; ΔT up to 160 °C) that cannot be explained simply by retrograde metamorphism or by tectonic amalgamation. Rather, our work suggests a significant role of deformation in producing variable pressure and temperature record within the rocks

Maternal Drinking During Pregnancy: Attention and Short-Term Memory in 14-Year-Old Offspring-A Longitudinal Prospective Study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66151/1/j.1530-0277.1994.tb00904.x.pd

The archeology of cognitive evolution

This discussion of archeology of cognition is concerned primarily with the evolutionary emergence of the cognition particular to modern humans but there is an implication for the evolution of cognition among modern humans. Archaeological evidence can provide important insights into the evolutionary emergence of human cognition, but theoretical considerations are fundamental in understanding what sorts of cognition there might have been between the ape-like common ancestor and modern humans. Archeology is the only source of evidence for the behavior associated with such theoretical stages. Cognitive archeology, therefore, involves an iterative interaction between theory from outside archeology and more or less direct evidence from the past. This review considers the range of possible evidence from archeology and genetics and summarizes some of the results of analysis of nonhuman primates particularly to assess characteristics of the last common ancestor (LCA) of apes and humans. The history of changes in size and shape of the brain since separation from other apes introduces the need to assess the appropriate cognitive theories to interpret such evidence. The review concentrates on two such approaches: Baddeley's working memory model as interpreted by Coolidge and Wynn, and Barnard’s interacting cognitive subsystems as it has been elaborated to define the cognitive conditions for hominins between the LCA and modern people. Most of the rest of the review considers how the evidence from stone tools might be consistent with such theoretical models of cognition. This evidence is consistent with views that modern human behavior only emerged in the last 100,000 years (or so) but it gives an explanation for that in terms of cognition

Endocasts and the evo-devo approach to study human brain evolution

The brain is a highly plastic organ and is shaped not only during prenatal but also during postnatal development. The analysis and comparison of ontogenetic patterns of endocranial size increase and endocranial shape changes can therefore add further evidence for the interpretation of hominin brain evolution. Here we focus on digital endocast data and the methodology used to document and compare developmental patterns of endocranial shape changes. We outline how geometric morphometrics of endocranial landmark data can be used in an evo-devo approach to human brain evolution, discuss how developmental simulations help to compare ontogenetic patterns among species, present different visualization techniques that help to interpret ontogenetic shape changes, provide an overview of our current knowledge, present new data on early postnatal shape changes in apes, and discuss open questions