1,657 research outputs found
The Mass Function of Newly Formed Stars (Review)
The topic of the stellar "original mass function" has a nearly 50 year
history,dating to the publication in 1955 of Salpeter's seminal paper. In this
review I discuss the many more recent results that have emerged on the initial
mass function (IMF), as it is now called, from studies over the last decade of
resolved populations in star forming regions and young open clusters.Comment: 9 pages, 1 figure; to appear in "The Dense Instellar Medium in
Galaxies -- 4'th Cologne-Bonn-Zermatt-Symposium" editted by S. Pfalzner, C.
Kramer, C. Straubmeier and A. Heithausen, Springer-Verlag (2004
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia
While research on T cell exhaustion in context of cancer particularly focuses on CD8C cytotoxic T cells, the
role of inhibitory receptors on CD4C T-helper cells have remained largely unexplored. TIGIT is a recently
identified inhibitory receptor on T cells and natural killer (NK) cells. In this study, we examined TIGIT
expression on T cell subsets from CLL patients. While we did not observe any differences in TIGIT expression
in CD8C T cells of healthy controls and CLL cells, we found an enrichment of TIGITC T cells in the CD4C T
cell compartment in CLL. Intriguingly, CLL patients with an advanced disease stage displayed elevated
numbers of CD4C TIGITC T cells compared to low risk patients. Autologous CLL-T cell co-culture assays
revealed that depleting CD4C TIGITC expressing T cells from co-cultures significantly decreased CLL viability.
Accordingly, a supportive effect of TIGITCCD4C T cells on CLL cells in vitro could be recapitulated by
blocking the interaction of TIGIT with its ligands using TIGIT-Fc molecules, which also impeded the T cell
specific production of CLL-prosurvival cytokines. Our data reveal that TIGITCCD4CT cells provide a
supportive microenvironment for CLL cells, representing a potential therapeutic target for CLL treatment
The nature of NV absorbers at high redshift
We present a study of NV absorption systems at 1.5 < z < 2.5 in the optical
spectra of 19 QSOs. Our analysis includes both absorbers arising from the
intergalactic medium as well as systems in the vicinity of the background
quasar. We construct detailed photoionization models to study the physical
conditions and abundances in the absorbers and to constrain the spectral
hardness of the ionizing radiation. The rate of incidence for intervening NV
components is dN/dz = 3.38 +/- 0.43, corresponding to dN/dX = 1.10 +/- 0.14.
The column density distribution function is fitted by the slope beta = 1.89 +/-
0.22, consistent with measurements for CIV and OVI. The narrow line widths
(b_NV ~ 6 km/s) imply photoionization rather than collisions as dominating
ionization process. The column densities of CIV and NV are correlated but show
different slopes for intervening and associated absorbers, which indicates
different ionizing spectra. Associated systems are found to be more metal-rich,
denser, and more compact than intervening absorbers. This conclusion is
independent of the adopted ionizing radiation. For the intervening NV systems
we find typical values of [C/H] ~ -0.6 and n_H ~ 10^-3.6 cm^-3, and sizes of a
few kpc, while for associated NV absorbers we obtain [C/H] ~ +0.7, n_H ~
10^-2.8 cm^-3, and sizes of several 10 pc. The abundance of nitrogen relative
to carbon [N/C] and alpha-elements like oxygen and silicon [N/alpha] is
correlated with [N/H], indicating the enrichment by secondary nitrogen. The
larger scatter in [N/alpha] in intervening systems suggests an inhomogeneous
enrichment of the IGM. There is an anti-correlation between [N/alpha] and
[alpha/C], which could be used to constrain the initial mass function of the
carbon- and nitrogen-producing stellar population.Comment: accepted by A&A, revised versio
The cometary composition of a protoplanetary disk as revealed by complex cyanides
Observations of comets and asteroids show that the Solar Nebula that spawned
our planetary system was rich in water and organic molecules. Bombardment
brought these organics to the young Earth's surface, seeding its early
chemistry. Unlike asteroids, comets preserve a nearly pristine record of the
Solar Nebula composition. The presence of cyanides in comets, including 0.01%
of methyl cyanide (CH3CN) with respect to water, is of special interest because
of the importance of C-N bonds for abiotic amino acid synthesis. Comet-like
compositions of simple and complex volatiles are found in protostars, and can
be readily explained by a combination of gas-phase chemistry to form e.g. HCN
and an active ice-phase chemistry on grain surfaces that advances
complexity[3]. Simple volatiles, including water and HCN, have been detected
previously in Solar Nebula analogues - protoplanetary disks around young stars
- indicating that they survive disk formation or are reformed in situ. It has
been hitherto unclear whether the same holds for more complex organic molecules
outside of the Solar Nebula, since recent observations show a dramatic change
in the chemistry at the boundary between nascent envelopes and young disks due
to accretion shocks[8]. Here we report the detection of CH3CN (and HCN and
HC3N) in the protoplanetary disk around the young star MWC 480. We find
abundance ratios of these N-bearing organics in the gas-phase similar to
comets, which suggests an even higher relative abundance of complex cyanides in
the disk ice. This implies that complex organics accompany simpler volatiles in
protoplanetary disks, and that the rich organic chemistry of the Solar Nebula
was not unique.Comment: Definitive version of the manuscript is published in Nature, 520,
7546, 198, 2015. This is the author's versio
Strong-coupling expansion and effective hamiltonians
When looking for analytical approaches to treat frustrated quantum magnets,
it is often very useful to start from a limit where the ground state is highly
degenerate. This chapter discusses several ways of deriving {effective
Hamiltonians} around such limits, starting from standard {degenerate
perturbation theory} and proceeding to modern approaches more appropriate for
the derivation of high-order effective Hamiltonians, such as the perturbative
continuous unitary transformations or contractor renormalization. In the course
of this exposition, a number of examples taken from the recent literature are
discussed, including frustrated ladders and other dimer-based Heisenberg models
in a field, as well as the mapping between frustrated Ising models in a
transverse field and quantum dimer models.Comment: To appear as a chapter in "Highly Frustrated Magnetism", Eds. C.
Lacroix, P. Mendels, F. Mil
Staircase Quantum Dots Configuration in Nanowires for Optimized Thermoelectric Power
The performance of thermoelectric energy harvesters can be improved by nanostructures that exploit inelastic transport processes. One prototype is the three-terminal hopping thermoelectric device where electron hopping between quantum-dots are driven by hot phonons. Such three-terminal hopping thermoelectric devices have potential in achieving high efficiency or power via inelastic transport and without relying on heavy-elements or toxic compounds. We show in this work how output power of the device can be optimized via tuning the number and energy configuration of the quantum-dots embedded in parallel nanowires. We find that the staircase energy configuration with constant energy-step can improve the power factor over a serial connection of a single pair of quantum-dots. Moreover, for a fixed energy-step, there is an optimal length for the nanowire. Similarly for a fixed number of quantum-dots there is an optimal energy-step for the output power. Our results are important for future developments of high-performance nanostructured thermoelectric devices
Evaluation of models to predict BRCA germline mutations
The selection of candidates for BRCA germline mutation testing is an important clinical issue yet it remains a significant challenge. A number of risk prediction models have been developed to assist in pretest counselling. We have evaluated the performance and the inter-rater reliability of four of these models (BRCAPRO, Manchester, Penn and the Myriad-Frank). The four risk assessment models were applied to 380 pedigrees of families who had undergone BRCA1/2 mutation analysis. Sensitivity, specificity, positive and negative predictive values, likelihood ratios and area under the receiver operator characteristic (ROC) curve were calculated for each model. Using a greater than 10% probability threshold, the likelihood that a BRCA test result was positive in a mutation carrier compared to the likelihood that the same result would be expected in an individual without a BRCA mutation was 2.10 (95% confidence interval (CI) 1.66–2.67) for Penn, 1.74 (95% CI 1.48–2.04) for Myriad, 1.35 (95% CI 1.19–1.53) for Manchester and 1.68 (95% CI 1.39–2.03) for BRCAPRO. Application of these models, therefore, did not rule in BRCA mutation carrier status. Similar trends were observed for separate BRCA1/2 performance measures except BRCA2 assessment in the Penn model where the positive likelihood ratio was 5.93. The area under the ROC curve for each model was close to 0.75. In conclusion, the four models had very little impact on the pre-test probability of disease; there were significant clinical barriers to using some models and risk estimates varied between experts. Use of models for predicting BRCA mutation status is not currently justified for populations such as that evaluated in the current study
Thermal Properties of Graphene, Carbon Nanotubes and Nanostructured Carbon Materials
Recent years witnessed a rapid growth of interest of scientific and
engineering communities to thermal properties of materials. Carbon allotropes
and derivatives occupy a unique place in terms of their ability to conduct
heat. The room-temperature thermal conductivity of carbon materials span an
extraordinary large range - of over five orders of magnitude - from the lowest
in amorphous carbons to the highest in graphene and carbon nanotubes. I review
thermal and thermoelectric properties of carbon materials focusing on recent
results for graphene, carbon nanotubes and nanostructured carbon materials with
different degrees of disorder. A special attention is given to the unusual size
dependence of heat conduction in two-dimensional crystals and, specifically, in
graphene. I also describe prospects of applications of graphene and carbon
materials for thermal management of electronics.Comment: Review Paper; 37 manuscript pages; 4 figures and 2 boxe
Isolated and dynamical horizons and their applications
Over the past three decades, black holes have played an important role in
quantum gravity, mathematical physics, numerical relativity and gravitational
wave phenomenology. However, conceptual settings and mathematical models used
to discuss them have varied considerably from one area to another. Over the
last five years a new, quasi-local framework was introduced to analyze diverse
facets of black holes in a unified manner. In this framework, evolving black
holes are modeled by dynamical horizons and black holes in equilibrium by
isolated horizons. We review basic properties of these horizons and summarize
applications to mathematical physics, numerical relativity and quantum gravity.
This paradigm has led to significant generalizations of several results in
black hole physics. Specifically, it has introduced a more physical setting for
black hole thermodynamics and for black hole entropy calculations in quantum
gravity; suggested a phenomenological model for hairy black holes; provided
novel techniques to extract physics from numerical simulations; and led to new
laws governing the dynamics of black holes in exact general relativity.Comment: 77 pages, 12 figures. Typos and references correcte
Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive, rapidly metastasising tumour. Previously, we demonstrated the influence of CXCL12–CXCR4 interaction on processes involved in metastasis and chemoresistance in SCLC. We show here that STAT3 is expressed in both primary SCLC tumour tissues and SCLC cell lines. We investigated the function of STAT3 upon CXCL12 stimulation in SCLC cell lines. Small cell lung cancer cell lines present constitutive phosphorylation of STAT3, and in the reference cell lines NCI-H69 and NCI-H82 constitutive phosphorylation was further increased by CXCL12 stimulation. Further investigating this signalling cascade, we showed that it involves interactions between CXCR4 and JAK2 in both cell lines. However CXCL12-induced adhesion to VCAM-1 could be completely inhibited by the JAK2 inhibitor AG490 only in NCI-H82. Furthermore, CXCR4 antagonist but not AG490 inhibited cell adhesion whereas both antagonisms were shown to inhibit growth of the cells in soft agar, indicating the central involvement of this signalling in anchorage-independent growth of SCLC cells. Most interestingly, while using primary tumour material, we observed that in contrast to non-small-cell lung cancer samples from primary tumour tissues, all analysed samples from SCLC were strongly positive for tyrosine-phosphorylated STAT3. Taken together, these data indicate that STAT3 is constitutively phosphorylated in SCLC and is important in SCLC growth and spreading thus presenting an interesting target for therapy
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