Mean-field analysis of the majority-vote model broken-ergodicity steady state

We study analytically a variant of the one-dimensional majority-vote model in which the individual retains its opinion in case there is a tie among the neighbors' opinions. The individuals are fixed in the sites of a ring of size $L$ and can interact with their nearest neighbors only. The interesting feature of this model is that it exhibits an infinity of spatially heterogeneous absorbing configurations for $L \to \infty$ whose statistical properties we probe analytically using a mean-field framework based on the decomposition of the $L$-site joint probability distribution into the $n$-contiguous-site joint distributions, the so-called $n$-site approximation. To describe the broken-ergodicity steady state of the model we solve analytically the mean-field dynamic equations for arbitrary time $t$ in the cases n=3 and 4. The asymptotic limit $t \to \infty$ reveals the mapping between the statistical properties of the random initial configurations and those of the final absorbing configurations. For the pair approximation ($n=2$) we derive that mapping using a trick that avoids solving the full dynamics. Most remarkably, we find that the predictions of the 4-site approximation reduce to those of the 3-site in the case of expectations involving three contiguous sites. In addition, those expectations fit the Monte Carlo data perfectly and so we conjecture that they are in fact the exact expectations for the one-dimensional majority-vote model

Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri

Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 Kusing the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6_122, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 Å, and contained two molecules in the asymetric unit. It diffracted to 2.24 Å resolution

Observing the temperature of the Big Bang through large scale structure

It is widely accepted that the Universe underwent a period of thermal equilibrium at very early times. One expects a residue of this primordial state to be imprinted on the large scale structure of space time. In this paper we study the morphology of this thermal residue in a universe whose early dynamics is governed by a scalar field. We calculate the amplitude of fluctuations on large scales and compare it to the imprint of vacuum fluctuations. We then use the observed power spectrum of fluctuations on the cosmic microwave background to place a constraint on the temperature of the Universe before and during inflation. We also present an alternative scenario where the fluctuations are predominantly thermal and near scale-invariant

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection. In the present work, we propose a multiscale mathematical model to study how the immune response interferes with the viral oncolytic activity. The model assumes that cytotoxic T cells can induce apoptosis in infected cancer cells and that free viruses can be inactivated by neutralizing antibodies or cleared at a constant rate by the innate immune response. Our simulations suggest that reprogramming the immune microenvironment in tumors could substantially enhance the oncolytic virotherapy in immune-competent hosts. Viable routes to such reprogramming are either in situ virus-mediated impairing of CD$8^+$ T cells motility or blockade of B and T lymphocytes recruitment. Our theoretical results can shed light on the design of viral vectors or new protocols with neat potential impacts on the clinical practice.Comment: 14 pages, 4 figure

Integrable theories and loop spaces: fundamentals, applications and new developments

We review our proposal to generalize the standard two-dimensional flatness construction of Lax-Zakharov-Shabat to relativistic field theories in d+1 dimensions. The fundamentals from the theory of connections on loop spaces are presented and clarified. These ideas are exposed using mathematical tools familiar to physicists. We exhibit recent and new results that relate the locality of the loop space curvature to the diffeomorphism invariance of the loop space holonomy. These result are used to show that the holonomy is abelian if the holonomy is diffeomorphism invariant. These results justify in part and set the limitations of the local implementations of the approach which has been worked out in the last decade. We highlight very interesting applications like the construction and the solution of an integrable four dimensional field theory with Hopf solitons, and new integrability conditions which generalize BPS equations to systems such as Skyrme theories. Applications of these ideas leading to new constructions are implemented in theories that admit volume preserving diffeomorphisms of the target space as symmetries. Applications to physically relevant systems like Yang Mills theories are summarized. We also discuss other possibilities that have not yet been explored.Comment: 64 pages, 8 figure

Dynamic Scaling of Non-Euclidean Interfaces

The dynamic scaling of curved interfaces presents features that are strikingly different from those of the planar ones. Spherical surfaces above one dimension are flat because the noise is irrelevant in such cases. Kinetic roughening is thus a one-dimensional phenomenon characterized by a marginal logarithmic amplitude of the fluctuations. Models characterized by a planar dynamical exponent $z>1$, which include the most common stochastic growth equations, suffer a loss of correlation along the interface, and their dynamics reduce to that of the radial random deposition model in the long time limit. The consequences in several applications are discussed, and we conclude that it is necessary to reexamine some experimental results in which standard scaling analysis was applied

Evaluating matrix elements relevant to some Lorenz violating operators

Carlson, Carone and Lebed have derived the Feynman rules for a consistent formulation of noncommutative QCD. The results they obtained were used to constrain the noncommutativity parameter in Lorentz violating noncommutative field theories. However, their constraint depended upon an estimate of the matrix element of the quark level operator (gamma.p - m) in a nucleon. In this paper we calculate the matrix element of (gamma.p - m), using a variety of confinement potential models. Our results are within an order of magnitude agreement with the estimate made by Carlson et al. The constraints placed on the noncommutativity parameter were very strong, and are still quite severe even if weakened by an order of magnitude.Comment: 4 pages, 3 figures, RevTex, minor change

Building analytical three-field cosmological models

A difficult task to deal with is the analytical treatment of models composed by three real scalar fields, once their equations of motion are in general coupled and hard to be integrated. In order to overcome this problem we introduce a methodology to construct three-field models based on the so-called "extension method". The fundamental idea of the procedure is to combine three one-field systems in a non-trivial way, to construct an effective three scalar field model. An interesting scenario where the method can be implemented is within inflationary models, where the Einstein-Hilbert Lagrangian is coupled with the scalar field Lagrangian. We exemplify how a new model constructed from our method can lead to non-trivial behaviors for cosmological parameters.Comment: 11 pages, and 3 figures, updated version published in EPJ