19 research outputs found
The multiple facets of the Hsp90 machine
International audienceThe Ninth International Conference on the Hsp90 Chaperone Machine concluded in October 2018, in Leysin, Switzerland. The program highlighted findings in various areas, including integrated insight into molecular mechanism of Hsp90, cochaperones, and clients’ structure and function.Heat shock protein-90 (Hsp90) is a molecular chaperone critical for the folding, stability, and activity of client proteins 1. Hsp90 and its orthologs, including bacterial HtpG, mitochondrial TRAP1 and endoplasmic reticulum Grp94, exist as dimers, hydrolyze ATP, and cycle between distinct conformational states. Hsp90 preferentially binds proteins in near native states facilitating their remodeling for protein interactions and signaling. At the 9th International Conference on the Hsp90 Chaperone Machine approximately one-third of the attendees shared their data on Hsp90 structure and function through short talks (Figure 1). Here, we distill and summarize their finding
Adnexal masses: benign ovarian lesions and characterization - benign ovarian masses
Incidental adnexal masses are commonly identified
in radiologists’ daily practice. Most of
them are benign ovarian lesions of no concern.
However, sometimes defining the origin of a
pelvic mass may be challenging, especially on
ultrasound alone. Moreover, ultrasound not
always allows the distinction between a benign
and a malignant adnexal tumor.
Most of sonographically indeterminate
adnexal masses turn out to be common benign
entities that can be readily diagnosed by magnetic
resonance imaging. The clinical impact
of predicting the likelihood of malignancy is
crucial for proper patient management.
The first part of this chapter will cover the
technical magnetic resonance imaging aspects
of ovarian lesions characterization as well as the
imaging features that allow the radiologist to
correctly define the anatomic origin of a pelvic
mass. Next, the authors will go through different
benign ovarian entities and through the different
histologic types of benign ovarian tumors.
Finally the functional ovarian tumors and the
ovarian tumors in children, adolescents, young
females, and pregnant women will be covered.info:eu-repo/semantics/publishedVersio