17 research outputs found
Sialolipom der Glandula parotis
Zusammenfassung: Das Sialolipom ist eine relativ neue und seltene Lipomvariante der Speicheldrüsen, welche durch die Kombination von klassischer Lipommorphologie mit nichtneoplastischen duktuloazinären Speicheldrüsenanteilen gekennzeichnet ist. Inklusive des vorliegenden Falles wurden bislang 27Sialolipome publiziert, davon 14 in der Glandula parotis. Wir beschreiben die klinischen, radiologischen und pathomorphologischen Eigenschaften eines Sialolipoms der Ohrspeicheldrüse bei einem 43Jahre alten Patiente
Intrahepatisches Sarkom der follikulär-dendritischen Zellen
Zusammenfassung: Wir berichten über ein primär intrahepatisches Sarkom der follikulär-dendritischen Zellen, das bei einer 76-jährigen Patientin auf dem Boden eines Morbus Castleman vom hyalin-vaskulären Typ auftrat. Wir diskutieren die klinisch-pathologischen Befunde, die Pathogenese und das differenzialdiagnostische Vorgehen bei diesem seltenen Tumorty
Zum kombinierten Hauen und Ruecken Ein experimenteller Beitrag
SIGLETIB: AC 7762 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
IMMUNO HISTOCHEMICAL EXPRESSION OF CLAUDIN-1 AS A PROGNOSTIC MARKER FOR PATIENT SURVIVAL IN RENAL CELL CARCINOMA
Entwicklung von Oelverbrauchsmessmethoden fuer Kolbenmaschinen unter Verwendung der Radionuklidtechnik Abschlussbericht. Beginn der Arbeit: 1973. Ende der Arbeit: 1977. Vorhaben Nr. 10-15
TIB Hannover: RA 1581 (249) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Dimensionierung von Oelleitungen, Berechnungsverfahren fuer Leitungsnetzwerke Forschungsvorhaben Nr. 42. [T. 2] Benutzeranleitung. Berichtszeitraum 1980
TIB: RN 3358 (97) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Expression of AGR2 in non small cell lung cancer
We aimed to evaluate immunohistochemically
the expression of the human Anterior
Gradient-2 (AGR2), a gene which has recently been
proposed as an oncogene for lung carcinoma
development, in non small cell lung cancer and to
correlate the findings to clinico-pathological data
including patient survival. 95 cases of NSCLC were
immunostained using a polyclonal AGR2 antibody and
statistical analyses were applied to test for prognostic
and diagnostic associations. AGR2 was expressed in
66.3% of cases, preferentially adenocarcinomas. There
were no relevant associations with clinico-pathological
paramaters. A prognostic value of AGR2 could not be
demonstrated neither in multivariate nor in univariate
analyses. Interestingly, this is the first study to
demonstrate AGR2 expression in squamous cell
carcinomas. Although a prognostic value of AGR2
seems unlikely further studies are warranted to
investigate the biological role of AGR2 in NSCLC and
its differential expression according to histology
Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma
Background/Aims: The human Anterior
Gradient-2 (AGR2) is strongly upregulated in various
human cancers, including pancreatic ductal
adenocarcinomas (PDAC), but its prognostic value in
PDAC has not yet been studied. Methods: We analysed
19 microdissected PDAC cases at the mRNA level, and
also 148 cases at the protein level by immunohistochemistry based on tissue microarray, using a
monoclonal AGR2 antibody, and statistical analyses
were applied to test for prognostic associations. Results:
Overexpression of AGR2 mRNA was found to be
elevated in most pancreatic cell lines and in
microdissected pancreatic cancer compared to
microdissected normal ductal cells. AGR2 protein was
expressed in 109/148 (73.7%) of PDAC, with a higher
expression in female patients (p=0.040), whereas no
significant associations with other clinical-pathological
parameters were found. A prognostic value of AGR2
could not be demonstrated in univariate analyses.
Conclusion: Although a prognostic value of AGR2
seems unlikely, further studies are warranted to
investigate the biological role of AGR2 in pancreatic
adenocarcinomas
Co-expression and prognostic value of gross cystic disease fluid protein 15 and mammaglobin in primary breast cancer
Gross cystic disease fluid protein (GCDFP-
15) and mammaglobin are both widely used and
accepted markers for epithelia of breast origin. We
aimed to evaluate their relation of expression on parallel
whole tissue sections in primary breast cancer by
immunohistochemistry and also to correlate it with
clinico-pathological parameters including patient
survival. Primary breast carcinomas from 165 patients
with a mean clinical follow-up of 73 months were
immunostained using commercially available antibodies
against GCDFP-15 and mammaglobin. An immunoreactive
score (IRS) was calculated based on the
cytoplasmic staining intensity and the number of cells
stained. Cytoplasmic expression of GCDFP-15 and
mammaglobin was observed in 73.3% and 72.1% of
invasive breast carcinomas respectively. 91.8% of breast
cancer cases expressed at least one of both markers.
Both markers strongly correlated with each other and
were significantly associated with lower tumour grading.
Additionally, GCDFP-15 negativity was significantly
associated with shortened disease-free survival times in
univariate and multivariate analyses. We demonstrated
the strong correlation of GCDFP-15 and mammaglobin
with each other and showed that only very few primary
breast cancers are completely negative for both markers.
The significantly longer disease free survival times for
patients with GCDFP-15 positive tumours clearly
warrants further study
Sialolipom der Glandula parotis
Sialolipoma is a relatively new and rare variant of lipoma of the salivary glands characterized by the combination of classical lipoma morphology with non-neoplastic ductulo-acinary salivary tissue components. Including the presented case, 27 sialolipomas, 14 of them localized in the parotid gland, have been published. We describe the clinical, radiological and pathomorphological characteristics of a parotid sialolipoma in a 43-year-old man