Sialolipom der Glandula parotis

Zusammenfassung: Das Sialolipom ist eine relativ neue und seltene Lipomvariante der Speicheldrüsen, welche durch die Kombination von klassischer Lipommorphologie mit nichtneoplastischen duktuloazinären Speicheldrüsenanteilen gekennzeichnet ist. Inklusive des vorliegenden Falles wurden bislang 27Sialolipome publiziert, davon 14 in der Glandula parotis. Wir beschreiben die klinischen, radiologischen und pathomorphologischen Eigenschaften eines Sialolipoms der Ohrspeicheldrüse bei einem 43Jahre alten Patiente

Intrahepatisches Sarkom der follikulär-dendritischen Zellen

Zusammenfassung: Wir berichten über ein primär intrahepatisches Sarkom der follikulär-dendritischen Zellen, das bei einer 76-jährigen Patientin auf dem Boden eines Morbus Castleman vom hyalin-vaskulären Typ auftrat. Wir diskutieren die klinisch-pathologischen Befunde, die Pathogenese und das differenzialdiagnostische Vorgehen bei diesem seltenen Tumorty

Zum kombinierten Hauen und Ruecken Ein experimenteller Beitrag

SIGLETIB: AC 7762 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Entwicklung von Oelverbrauchsmessmethoden fuer Kolbenmaschinen unter Verwendung der Radionuklidtechnik Abschlussbericht. Beginn der Arbeit: 1973. Ende der Arbeit: 1977. Vorhaben Nr. 10-15

TIB Hannover: RA 1581 (249) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Dimensionierung von Oelleitungen, Berechnungsverfahren fuer Leitungsnetzwerke Forschungsvorhaben Nr. 42. [T. 2] Benutzeranleitung. Berichtszeitraum 1980

TIB: RN 3358 (97) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Expression of AGR2 in non small cell lung cancer

We aimed to evaluate immunohistochemically the expression of the human Anterior Gradient-2 (AGR2), a gene which has recently been proposed as an oncogene for lung carcinoma development, in non small cell lung cancer and to correlate the findings to clinico-pathological data including patient survival. 95 cases of NSCLC were immunostained using a polyclonal AGR2 antibody and statistical analyses were applied to test for prognostic and diagnostic associations. AGR2 was expressed in 66.3% of cases, preferentially adenocarcinomas. There were no relevant associations with clinico-pathological paramaters. A prognostic value of AGR2 could not be demonstrated neither in multivariate nor in univariate analyses. Interestingly, this is the first study to demonstrate AGR2 expression in squamous cell carcinomas. Although a prognostic value of AGR2 seems unlikely further studies are warranted to investigate the biological role of AGR2 in NSCLC and its differential expression according to histology

Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma

Background/Aims: The human Anterior Gradient-2 (AGR2) is strongly upregulated in various human cancers, including pancreatic ductal adenocarcinomas (PDAC), but its prognostic value in PDAC has not yet been studied. Methods: We analysed 19 microdissected PDAC cases at the mRNA level, and also 148 cases at the protein level by immunohistochemistry based on tissue microarray, using a monoclonal AGR2 antibody, and statistical analyses were applied to test for prognostic associations. Results: Overexpression of AGR2 mRNA was found to be elevated in most pancreatic cell lines and in microdissected pancreatic cancer compared to microdissected normal ductal cells. AGR2 protein was expressed in 109/148 (73.7%) of PDAC, with a higher expression in female patients (p=0.040), whereas no significant associations with other clinical-pathological parameters were found. A prognostic value of AGR2 could not be demonstrated in univariate analyses. Conclusion: Although a prognostic value of AGR2 seems unlikely, further studies are warranted to investigate the biological role of AGR2 in pancreatic adenocarcinomas

Co-expression and prognostic value of gross cystic disease fluid protein 15 and mammaglobin in primary breast cancer

Gross cystic disease fluid protein (GCDFP- 15) and mammaglobin are both widely used and accepted markers for epithelia of breast origin. We aimed to evaluate their relation of expression on parallel whole tissue sections in primary breast cancer by immunohistochemistry and also to correlate it with clinico-pathological parameters including patient survival. Primary breast carcinomas from 165 patients with a mean clinical follow-up of 73 months were immunostained using commercially available antibodies against GCDFP-15 and mammaglobin. An immunoreactive score (IRS) was calculated based on the cytoplasmic staining intensity and the number of cells stained. Cytoplasmic expression of GCDFP-15 and mammaglobin was observed in 73.3% and 72.1% of invasive breast carcinomas respectively. 91.8% of breast cancer cases expressed at least one of both markers. Both markers strongly correlated with each other and were significantly associated with lower tumour grading. Additionally, GCDFP-15 negativity was significantly associated with shortened disease-free survival times in univariate and multivariate analyses. We demonstrated the strong correlation of GCDFP-15 and mammaglobin with each other and showed that only very few primary breast cancers are completely negative for both markers. The significantly longer disease free survival times for patients with GCDFP-15 positive tumours clearly warrants further study

Sialolipom der Glandula parotis

Sialolipoma is a relatively new and rare variant of lipoma of the salivary glands characterized by the combination of classical lipoma morphology with non-neoplastic ductulo-acinary salivary tissue components. Including the presented case, 27 sialolipomas, 14 of them localized in the parotid gland, have been published. We describe the clinical, radiological and pathomorphological characteristics of a parotid sialolipoma in a 43-year-old man