376 research outputs found
Cerulean: A hybrid assembly using high throughput short and long reads
Genome assembly using high throughput data with short reads, arguably,
remains an unresolvable task in repetitive genomes, since when the length of a
repeat exceeds the read length, it becomes difficult to unambiguously connect
the flanking regions. The emergence of third generation sequencing (Pacific
Biosciences) with long reads enables the opportunity to resolve complicated
repeats that could not be resolved by the short read data. However, these long
reads have high error rate and it is an uphill task to assemble the genome
without using additional high quality short reads. Recently, Koren et al. 2012
proposed an approach to use high quality short reads data to correct these long
reads and, thus, make the assembly from long reads possible. However, due to
the large size of both dataset (short and long reads), error-correction of
these long reads requires excessively high computational resources, even on
small bacterial genomes. In this work, instead of error correction of long
reads, we first assemble the short reads and later map these long reads on the
assembly graph to resolve repeats.
Contribution: We present a hybrid assembly approach that is both
computationally effective and produces high quality assemblies. Our algorithm
first operates with a simplified version of the assembly graph consisting only
of long contigs and gradually improves the assembly by adding smaller contigs
in each iteration. In contrast to the state-of-the-art long reads error
correction technique, which requires high computational resources and long
running time on a supercomputer even for bacterial genome datasets, our
software can produce comparable assembly using only a standard desktop in a
short running time.Comment: Peer-reviewed and presented as part of the 13th Workshop on
Algorithms in Bioinformatics (WABI2013
The Solution Space of the Unitary Matrix Model String Equation and the Sato Grassmannian
The space of all solutions to the string equation of the symmetric unitary
one-matrix model is determined. It is shown that the string equation is
equivalent to simple conditions on points and in the big cell \Gr
of the Sato Grassmannian . This is a consequence of a well-defined
continuum limit in which the string equation has the simple form \lb \cp
,\cq_- \rb =\hbox{\rm 1}, with \cp and \cq_- matrices of
differential operators. These conditions on and yield a simple
system of first order differential equations whose analysis determines the
space of all solutions to the string equation. This geometric formulation leads
directly to the Virasoro constraints \L_n\,(n\geq 0), where \L_n annihilate
the two modified-KdV \t-functions whose product gives the partition function
of the Unitary Matrix Model.Comment: 21 page
Current-Driven Magnetization Dynamics in Magnetic Multilayers
We develop a quantum analog of the classical spin-torque model for
current-driven magnetic dynamics. The current-driven magnetic excitation at
finite field becomes significantly incoherent. This excitation is described by
an effective magnetic temperature rather than a coherent precession as in the
spin-torque model. However, both the spin-torque and effective temperature
approximations give qualitatively similar switching diagrams in the
current-field coordinates, showing the need for detailed experiments to
establish the proper physical model for current-driven dynamics.Comment: 5 pages, 2 figure
Analytical solution of generalized Burton--Cabrera--Frank equations for growth and post--growth equilibration on vicinal surfaces
We investigate growth on vicinal surfaces by molecular beam epitaxy making
use of a generalized Burton--Cabrera--Frank model. Our primary aim is to
propose and implement a novel analytical program based on a perturbative
solution of the non--linear equations describing the coupled adatom and dimer
kinetics. These equations are considered as originating from a fully
microscopic description that allows the step boundary conditions to be directly
formulated in terms of the sticking coefficients at each step. As an example,
we study the importance of diffusion barriers for adatoms hopping down
descending steps (Schwoebel effect) during growth and post-growth equilibration
of the surface.Comment: 16 pages, REVTeX 3.0, IC-DDV-94-00
Current induced switching of magnetic domains to a perpendicular configuration
In a ferromagnet--normal-metal--ferromagnet trilayer, a current flowing
perpendicularly to the layers creates a torque on the magnetic moments of the
ferromagnets. When one of the contacts is superconducting, the torque not only
favors parallel or antiparallel alignment of the magnetic moments, as is the
case for two normal contacts, but can also favor a configuration where the two
moments are perpendicular. In addition, whereas the conductance for parallel
and antiparallel magnetic moments is the same, signalling the absence of giant
magnetoresistance in the usual sense, the conductance is greater in the
perpendicular configuration. Thus, a negative magnetoconductance is predicted,
in contrast with the usual giant magnetoresistance.Comment: 4 pages, 3 figures, major rewriting of the technical par
New Kadampa Buddhists and Jungian psychological type
Building on previous studies on Canadian Anglicans and Catholics, this study examines and discusses the psychological type profile of 31 adherents to New Kadampa Buddhism. Like Anglicans and Catholics, Buddhists preferred introversion (I). Like Anglicans who preferred intuition (N) and unlike Catholics who preferred sensing (S), Buddhists displayed a preference for intuition (N). Unlike Anglicans and Catholics who both preferred feeling (F), Buddhists displayed a balance between feeling (F) and thinking (T). Like Anglicans and unlike Catholics, Buddhists preferred the Apollonian temperament (NF) over the Epimethean temperament (SJ). These data are discussed to interpret the psychological appeal of New Kadampa Buddhism
Magnetization dynamics with a spin-transfer torque
The magnetization reversal and dynamics of a spin valve pillar, whose lateral
size is 6464 nm, are studied by using micromagnetic simulation in
the presence of spin transfer torque. Spin torques display both characteristics
of magnetic damping (or anti-damping) and of an effective magnetic field. For a
steady-state current, both M-I and M-H hysteresis loops show unique features,
including multiple jumps, unusual plateaus and precessional states. These
states originate from the competition between the energy dissipation due to
Gilbert damping and the energy accumulation due to the spin torque supplied by
the spin current. The magnetic energy oscillates as a function of time even for
a steady-state current. For a pulsed current, the minimum width and amplitude
of the spin torque for achieving current-driven magnetization reversal are
quantitatively determined. The spin torque also shows very interesting thermal
activation that is fundamentally different from an ordinary damping effect.Comment: 15 figure
Stationary Einstein-Maxwell fields in arbitrary dimensions
The Einstein-Maxwell equations in D-dimensions admitting (D-3) commuting
Killing vector fields have been investigated. The existence of the electric,
magnetic and twist potentials have been proved. The system is formulated as the
harmonic map coupled to gravity on three-dimensional base space generalizing
the Ernst system in the four-dimensional stationary Einstein-Maxwell theory.
Some classes of the new exact solutions have been provided, which include the
electro-magnetic generalization of the Myers-Perry solution, which describes
the rotating black hole immersed in a magnetic universe, and the static charged
black ring solution.Comment: 26 page
Magnetic exchange interaction induced by a Josephson current
We show that a Josephson current flowing through a
ferromagnet-normal-metal-ferromagnet trilayer connected to two superconducting
electrodes induces an equilibrium exchange interaction between the magnetic
moments of the ferromagnetic layers. The sign and magnitude of the interaction
can be controlled by the phase difference between the order parameters of the
two superconductors. We present a general framework to calculate the Josephson
current induced magnetic exchange interaction in terms of the scattering
matrices of the different layers. The effect should be observable as the
periodic switching of the relative orientation of the magnetic moments of the
ferromagnetic layers in the ac Josephson effect.Comment: 12 pages, 7 figure
Spin pumping and magnetization dynamics in metallic multilayers
We study the magnetization dynamics in thin ferromagnetic films and small
ferromagnetic particles in contact with paramagnetic conductors. A moving
magnetization vector causes \textquotedblleft pumping\textquotedblright of
spins into adjacent nonmagnetic layers. This spin transfer affects the
magnetization dynamics similar to the Landau-Lifshitz-Gilbert phenomenology.
The additional Gilbert damping is significant for small ferromagnets, when the
nonmagnetic layers efficiently relax the injected spins, but the effect is
reduced when a spin accumulation build-up in the normal metal opposes the spin
pumping. The damping enhancement is governed by (and, in turn, can be used to
measure) the mixing conductance or spin-torque parameter of the
ferromagnet--normal-metal interface. Our theoretical findings are confirmed by
agreement with recent experiments in a variety of multilayer systems.Comment: 10 pages, 6 figure
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