SO(10) unified models and soft leptogenesis

Motivated by the fact that, in some realistic models combining SO(10) GUTs and flavour symmetries, it is not possible to achieve the required baryon asymmetry through the CP asymmetry generated in the decay of right-handed neutrinos, we take a fresh look on how deep this connection is in SO(10). The common characteristics of these models are that they use the see-saw with right-handed neutrinos, predict a normal hierarchy of masses for the neutrinos observed in oscillating experiments and in the basis where the right-handed Majorana mass is diagonal, the charged lepton mixings are tiny. In addition these models link the up-quark Yukawa matrix to the neutrino Yukawa matrix Y^\nu with the special feature of Y^\nu_{11}-> 0 Using this condition, we find that the required baryon asymmetry of the Universe can be explained by the soft leptogenesis using the soft B parameter of the second lightest right-handed neutrino whose mass turns out to be around 10^8 GeV. It is pointed out that a natural way to do so is to use no-scale supergravity where the value of B ~1 GeV is set through gauge-loop corrections.Comment: 26 pages, 2 figures. Added references, new appendix of a relevant fit and improved comment

Dynamical stability of infinite homogeneous self-gravitating systems: application of the Nyquist method

We complete classical investigations concerning the dynamical stability of an infinite homogeneous gaseous medium described by the Euler-Poisson system or an infinite homogeneous stellar system described by the Vlasov-Poisson system (Jeans problem). To determine the stability of an infinite homogeneous stellar system with respect to a perturbation of wavenumber k, we apply the Nyquist method. We first consider the case of single-humped distributions and show that, for infinite homogeneous systems, the onset of instability is the same in a stellar system and in the corresponding barotropic gas, contrary to the case of inhomogeneous systems. We show that this result is true for any symmetric single-humped velocity distribution, not only for the Maxwellian. If we specialize on isothermal and polytropic distributions, analytical expressions for the growth rate, damping rate and pulsation period of the perturbation can be given. Then, we consider the Vlasov stability of symmetric and asymmetric double-humped distributions (two-stream stellar systems) and determine the stability diagrams depending on the degree of asymmetry. We compare these results with the Euler stability of two self-gravitating gaseous streams. Finally, we determine the corresponding stability diagrams in the case of plasmas and compare the results with self-gravitating systems

Colliders and Cosmology

Dark matter in variations of constrained minimal supersymmetric standard models will be discussed. Particular attention will be given to the comparison between accelerator and direct detection constraints.Comment: Submitted for the SUSY07 proceedings, 15 pages, LaTex, 26 eps figure

History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York

Towards Jetography

As the LHC prepares to start taking data, this review is intended to provide a QCD theorist's understanding and views on jet finding at hadron colliders, including recent developments. My hope is that it will serve both as a primer for the newcomer to jets and as a quick reference for those with some experience of the subject. It is devoted to the questions of how one defines jets, how jets relate to partons, and to the emerging subject of how best to use jets at the LHC.Comment: 95 pages, 28 figures, an extended version of lectures given at the CTEQ/MCNET school, Debrecen, Hungary, August 2008; v2 includes additional discussion in several places, as well as other clarifications and additional references

Schistosoma mansoni CBP/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1

Metazoan species diversification in general and the adaptation of parasites to their life-style in particular are due, not only to the evolution of different structural or metabolic proteins, but also to changes in the expression patterns of the corresponding genes. In order to explore the conservation/divergence of transcriptional regulation in the platyhelminth parasite Schistosoma mansoni, we are studying the structures and functions of transcriptional mediators. CREB-binding protein (CBP) and p300 are closely related transcriptional coactivators that possess histone acetyltransferase (HAT) activity that can modify chromatin to an active relaxed state. They are also thought to link transcription factors to the basic transcriptional machinery and to act as integrators for different regulatory pathways. Here we describe the cloning and functional characterization of S. mansoni CBP. SmCBP1 comprises 2093 amino acids and displays a conserved modular domain structure. The HAT domain was shown to acetylate histones with a marked activity toward H4. Functional studies showed that SmCBP1 could interact physically with the nuclear receptor SmFtz-F1 and also potentiated its transcriptional activity in the CV-1 cell line. Screening of the EST and genomic sequence databases with the SmCBP1 sequence allowed us to characterize a second CBP gene in S. mansoni. SmCBP2 shows a high degree of sequence identity to SmCBP1, particularly in the HAT domain. Phylogenetic studies show that these peptides are more closely related to each other than to either mammalian CBP or p300, suggesting that they derive from a platyhelminth-specific duplication event. Both genes are expressed at all life-cycle stages, but differences in their relative expression and structural variations suggest that they play distinct roles in schistosome gene regulation. © 2005 Elsevier B.V. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Finite element based acoustic analysis of dissipative silencers with high temperature and thermal-induced heterogeneity

A mixed finite element model has been derived for the acoustic analysis of perforated dissipative silencers including several effects simultaneously: (1) High temperature and thermal gradients in the central duct and the outer absorbent material; (2) a perforated passage carrying non-uniform axial mean flow. For such a combination, the properties of sound propagation media and flow are inhomogeneous and vary with position. The material of the outer chamber can be modelled by its complex equivalent acoustic properties, which completely determine the propagation of sound waves in the air contained in the absorbent medium. Temperature gradients introduce variations in these properties that can be evaluated through a heterogeneous temperature-dependent resistivity in combination with material models obtained at room temperature. A pressure-based wave equation for stationary medium is then used with the equivalent density and speed of sound of the absorbent material varying as functions of the spatial coordinates. Regarding the central air passage, a wave equation in terms of acoustic velocity potential can be used to model the non-uniform moving medium since the presence of temperature variations introduce not only heterogeneous acoustic properties of the air but also a gradient in the mean flow velocity. The acoustic connection between the central passage and the outer chamber is given by the acoustic impedance of the perforated duct. This impedance depends on the heterogeneous properties of the absorbent material and the non-uniform mean flow, leading to a spatial variation of the acoustic coupling and also to additional convective terms in the governing equations. The results presented show the influence of temperature, thermal gradients and mean flow on the transmission loss of automotive silencers. It has been found that high temperature and thermal-induced heterogeneity can have a significant influence on the acoustic attenuation of an automotive silencer and so should be included in theoretical models. In some particular configurations it may be relatively accurate to approximate the temperature field by using a uniform profile with an average value, specially for low resistivity materials. It has been shown, however, that this is not always possible and attenuation overestimation is likely to be predicted, mainly for high radial thermal gradients and high material flow resistivities, if the temperature distribution is not taken into account.Authors gratefully acknowledge the financial support of Ministerio de Economía y Competitividad and the European Regional Development Fund (projects DPI2010-15412 and TRA2013-45596-C2-1-R), Generalitat Valenciana (project Prometeo/2012/023) and Universitat Politècnica de València (PAID-05-12, project SP20120452)