Exterior powers in Iwasawa theory

The Iwasawa theory of CM fields has traditionally concerned Iwasawa modules that are abelian pro-p Galois groups with ramification allowed at a maximal set of primes over p such that the module is torsion. A main conjecture for such an Iwasawa module describes its codimension one support in terms of a p-adic L-function attached to the primes of ramification. In this paper, we study more general and potentially much smaller Iwasawa modules that are quotients of exterior powers of Iwasawa modules with ramification at a set of primes over p by sums of exterior powers of inertia subgroups. We show that the higher codimension support of such quotients can be measured by finite collections of p-adic L-functions under the relevant CM main conjectures.Comment: 41 pages, to appear in J. Eur. Math. So

Effect of interleukin-22 on immunogenicity of DNA vaccine encoding TSA gene of leishmania major in BALB/c mice

Background and purpose: Previous Research shows the use of plasmids containing genes TSA to be useful as vaccines for Leishmania major. Recently, the role of interleukin-22 (IL-22) in tissue repair has been demonstrated. In this research, the effect of IL-22 on encoding TSA gene of Leishmania major in BALB/c mice was assessed

Finding the solution of nonlinear equations by a class of optimal methods

AbstractThis paper is devoted to the study of an iterative class for numerically approximating the solution of nonlinear equations. In fact, a general class of iterations using two evaluations of the first order derivative and one evaluation of the function per computing step is presented. It is also proven that the class reaches the fourth-order convergence. Therefore, the novel methods from the class are Jarratt-type iterations, which agree with the optimality hypothesis of Kung–Traub. The derived class is further extended for multiple roots. That is to say, a general optimal quartic class of iterations for multiple roots is contributed, when the multiplicity of the roots is available. Numerical experiments are employed to support the theory developed in this work

Veronica persica Poir. extract - antibacterial, antifungal and scolicidal activities, and inhibitory potential on acetylcholinesterase, tyrosinase, lipoxygenase and xanthine oxidase

Veronica persica (Persian speedwell) is a flowering plant local to Eurasia. In this study, several analyses were done to discover the antimicrobial and scolicidal activities and acetyl cholinesterase (AChE), tyrosinase (TYR), lipoxygenase (LOX), and xanthine oxidase (XO) inhibitory activities of V. persica extract. The results presented that B. subtilis was the most susceptible to the extract (MIC = 40.3 \u3bcg/mL), while P. aeruginosa was the most resistant strain (MIC = 250.9 \u3bcg/mL) among all bacteria evaluated. The extracts demonstrated significant activity versus E. granulosus (P < 0.5) with dose-dependent inhibitions of the protoscolices. The analyzed plant extract exhibited a high AChE and TYR inhibitory activity 55.3% and 52.7% (at the highest utilized dose - 3 mg/mL), respectively. The extract also showed high anti-inflammatory activities in analyses tested. Our research proposed that extract of this plant could be promising to the human health, markedly in the infectious, neurodegenerative and inflammatory disorders

Expression of complete rhoptry protein 2 (ROP2) gene of Toxoplasma gondii in eukaryotic cell

Toxoplasma gondii is the intracellular protozoan parasite responsible for animal and human toxoplasmosis. In immunodeficient patients, chronic infection with T. gondii can reactivate and produceencephalitis, which is often lethal. ROP2 (rhoptry protein of T. gondii) is one of the most important interferer in organelle and PVM blending. ROP2 protein is recognized by clone T-cell (Tcc32) in humanbody and also has epitope for B-cell. All of these characteristics of ROP2 makes it a candidate for cocktail vaccine and recombinant vaccine against toxoplasmosis. We described the expression of thegene which encodes the complete rhoptry protein 2 (ROP2) of T. gondii in CHO cells and confirmed it by SDS-PAGE and Western blot analysis. In the present work, genomic DNA of T. gondii was extractedand used for amplifying of ROP2 gene as a template. Then PCR product was cloned into pTZ57R/T vector, and plasmid containing ROP2 gene (pT-ROP2) was extracted from transformed bacteria andsequenced. We hope to use from this recombinant plasmid (pT-ROP2) to make DNA vaccine against toxoplasmosis

Prevalence of Metabolic Syndrome in an Adult Urban Population of the West of Iran

Objectives. We determine the prevalence of the metabolic syndrome in an urban population of Zanjan, a province located to the west of Tehran. Methods. Randomly selected adults >20 years were studied using stratified sampling. Target study sample was 2941 (1396 males and 1545 females). Metabolic syndrome was diagnosed using Adult Treatment Panel-III (ATP-III) guidelines when any three of the following were present: central obesity, raised triglycerides ≥150 mg/dl, low high-density lipoprotein (HDL) cholesterol, blood pressure ≥ 130/ ≥ 85 mm Hg, and diabetes or fasting plasma glucose (FPG) ≥ 100 mg/dl. Results. Metabolic syndrome was present in 697 (23.7%) subjects (CI 95%:22%–25%, P = .001), prevalence was 23.1% in men and 24.4% in women (P : .4). The prevalence increased from 7.5% in the population younger than 30 y to 45.6% in ages more than 50 years. Low HDL was the most common metabolic abnormality in both sexes. Most of those with metabolic syndrome had three components of the syndrome (75.6%), 170 subjects (24.4%) had four and none had five components simultaneously. The prevalence of obesity (BMI ≥ 30 kg/m2), hypercholesterolemia (≥200 mg/dl) and high LDL cholesterol (≥130 mg/dl) was greater in the metabolic syndrome group than normal subjects (P = .00). Conclusions. There is a high prevalence of metabolic syndrome in this urban population of the northern west of Iran. Focus of cardiovascular prevention should be undertaken in this area

DJELOVANJE MIJEŠANJA I RAZINE UKLJUČIVANJA SOJINOG ULJA I NJEGOVE ZAKISELJENE SAPUNASTE SMJESE NA REZULTATE BROJLERA

This study was conducted to investigate the effect of diets containing blends of soy oil and its acidulated soapstock on broiler performance. Six hundred 7–day-old Ross broiler chicks were assigned to factorial arrangement (2×5) with 2 levels of oil (3 , 6%) and 5 blends of soy oil and its soapstock (100:0, 75:25, 50:50, 25:75 and 0:100) with 4 replicates in a completely randomized design . The levels of inclusion of fat in diets had a significant effect on feed intake and feed conversion ratio(FCR), and birds fed diets containing 3% of fat had higher weight gain and better FCR (P<0.05). Weight gain and feed conversion ratio were significantly (P<0.05) affected by the blending ratio of soy oil and its acidulated soapstock. The soy oil: soapstock ratio of 0:100, in diet resulted in significantly lower weight gain, but there were not any significant differences between other blending ratios on weight gain and FCR. The interaction effects of fat levels× blending ratio of soy oil and its acidulated soapstock were significant on weight gain and FCR in the whole rearing period. The weight gain of birds receiving diets containing 6% of fat with the 0:100 (soy oil: soapstock) were significantly lower (P < 0.05) than those in the other treatments. It was concluded that the acidulated soy oil soapstock could be used as an energy source in broiler diets, and the soy oil replaced witht its soapstock by 75% in the whole rearing period.Ovaj je rad proveden radi istraživanja djelovanja obroka sa soijnim uljem i njegovom zakiseljenom sapunastom smjesom na rezultate brojlerskih pilića. Šest 7 dana starih brojlerskih pilića linije Ross svrstano je u faktorijalni red (2x5) s dvije količine ulja (3%,6%) i 5 mješavina sojinog ulja i njegove sapunaste smjese (100:0, 75:25, 50:50, 25:75 i 0:100) s 4 ponavljanja u potpuno slučajnom planu. Razine uključivanja masnoće u obroke imale su značajan učinak na uzimanje hrane i omjer konverzije hrane (FCR), te su pilići hranjeni obrocima s 3% masnoće imali veći prirast tjelesne mase i bolji FCR (P<0.05). Na prirast tjelesne mase i omjer konverzije hrane značajno je djelovao omjer miješanja sojinog ulja i njegove zakiseljene sapunaste smjese (P<0.05). Omjer sojino ulje: sapunasta smjesa od 0:100 u obrocima rezultirao je značajno nižim prirastom tjelesne mase ali nije bilo nikakve druge značajne razlike između drugih omjera miješanja na prirast tjelesne mase i na FCR. Djelovanje interakcije razine masti x omjer miješanja sojinog ulja i zakiseljene sapunaste smjese bilo je značajno na prirast tjelesne mase i FCR u čitavom razdoblju uzgoja. Prirast tjelesne mase pilića koji su dobivali obroke sa 6% masti s 0:100 (sojino ulje : sapunasta smjesa) bio je značajno niži (P<0,05) od prirasta pilića u drugim tretiranjima. Zaključuje se da bi se zakiseljena sapunasta smjesa sojinog ulja mogla upotrijebiti kao izvor energije u obrocima brojlera a sojino ulje nadomjestiti sa 75% sapunaste smjese u čitavom uzgojnom razdoblju

Effect of IL-22 on DNA vaccine encoding LACK gene of Leishmania major in BALB/c mice

In the present study, the effect of IL-22 together with the plasmid encoding LACK (Leishmania homolog of receptors for activated C-kinase) gene of Leishmania major on the trend of leishmaniasis in BALB/c mice was evaluated.Evaluation of the cellular and humoral immunity was performed by measurement of IL-4 and IFN-γ, culture of splenocytes and MTT assay, and measurement of total IgG, IgG1, and IgG2a in the control and immunized groups. Clinical evaluations were also carried out by measurement of the lesion size, survival rate, and body weight of mice.Comparison of the mean size of lesions in the LACK and LACK. +. IL-22 groups demonstrated that the mean size of lesions of the two groups was significantly different from week four (p<. 0.05).The survival rate at day 170 after challenge for the PBS, pcDNA3 (empty plasmid), pcLACK (pcDNA3 containing LACK gene), and pcLACK. +. IL-22 groups were 20%, 40%, 60%, and 80%, respectively.According to the results of IFN-γ, IL-4, total IgG, IgG1, and IgG2a measurement and the MTT assay, IL-22 obviously caused an increase in IFN-γ production and a decrease in IL-4 production before and after the challenge (p<. 0.05). The results showed the effectiveness of IL-22 in DNA vaccine. It showed that IL-22 brought about Th1 cytokine responses and high survival rate of mice. © 2013 Elsevier Inc