1,709 research outputs found
System for measuring passenger reaction to transportation-vehicle vibration
Equipment is capable of measuring frequencies from 0 to 50 Hz and is portable, light, inexpensive, and easily adaptable to field operations. System could be used in situations where it is necessary to record simultaneously subject response to other types of physical measurement or stimuli, such as temperature, noise, or pressure
The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice.
RATIONALE
Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice.
OBJECTIVE
We test the ability of GSK1521498 to reduce alcohol consumption and compare its intrinsic efficacy to that of naltrexone by comparing the two drugs at doses matched for equivalent receptor occupancy.
METHODS
Thirty-six C57BL/6J mice were tested in a DID procedure. In 2-day cycles, animals experienced one baseline, injection-free session, and one test session when they received two injections, one of test drug and one placebo. All animals received GSK1521498 (0, 0.1, 1 and 3Â mg/kg, i.p., 30Â min pre-treatment) and naltrexone (0, 0.1, 1 and 3Â mg/kg, s.c. 10Â min pre-treatment) in a cross-over design. Receptor occupancies following the same doses were determined ex vivo in separate groups by autoradiography, using [3H]DAMGO. Binding in the region of interest was measured integrally by computer-assisted microdensitometry and corrected for non-specific binding.
RESULTS
Both GSK1521498 and naltrexone dose-dependently decreased ethanol consumption. When drug doses were matched for 70-75Â % receptor occupancy, GSK1521498 3Â mg/kg, i.p., caused a 2.5-fold greater reduction in alcohol consumption than naltrexone 0.1Â mg/kg, s.c. Both GSK1521498 and naltrexone significantly reduced sucrose consumption at a dose of 1Â mg/kg but not 0.1Â mg/kg. In a test of conditioned taste aversion, GSK1521498 (3Â mg/kg) reduced sucrose consumption 24Â h following exposure to a conditioning injection.
CONCLUSIONS
Both opioid receptor antagonists reduced alcohol consumption but GK1521498 has higher intrinsic efficacy than naltrexone
Counting defects with the two-point correlator
We study how topological defects manifest themselves in the equal-time
two-point field correlator. We consider a scalar field with Z_2 symmetry in 1,
2 and 3 spatial dimensions, allowing for kinks, domain lines and domain walls,
respectively. Using numerical lattice simulations, we find that in any number
of dimensions, the correlator in momentum space is to a very good approximation
the product of two factors, one describing the spatial distribution of the
defects and the other describing the defect shape. When the defects are
produced by the Kibble mechanism, the former has a universal form as a function
of k/n, which we determine numerically. This signature makes it possible to
determine the kink density from the field correlator without having to resort
to the Gaussian approximation. This is essential when studying field dynamics
with methods relying only on correlators (Schwinger-Dyson, 2PI).Comment: 11 pages, 7 figures
A Grand Canonical Ensemble Approach to the Thermodynamic Properties of the Nucleon in the Quark-Gluon Coupling Model
In this paper, we put forward a way to study the nucleon's thermodynamic
properties such as its temperature, entropy and so on, without inputting any
free parameters by human hand, even the nucleon's mass and radius. First we use
the Lagrangian density of the quark gluon coupling fields to deduce the Dirac
Equation of the quarks confined in the gluon fields. By boundary conditions we
solve the wave functions and energy eigenvalues of the quarks, and thus get
energy-momentum tensor, nucleon mass, and density of states. Then we utilize a
hybrid grand canonical ensemble, to generate the temperature and chemical
potentials of quarks, antiquarks of three flovars by the four conservation laws
of the energy and the valence quark numbers, after which, all other
thermodynamic properties are known. The only seemed free paremeter, the nucleon
radius is finally determined by the grand potential minimal principle.Comment: 5 pages, LaTe
Metric Fluctuation Corrections to Hawking Radiation
We study how fluctuations of the black hole geometry affect the properties of
Hawking radiation. Even though we treat the fluctuations classically, we
believe that the results so obtained indicate what might be the effects induced
by quantum fluctuations in a self consistent treatment. To characterize the
fluctuations, we use the model introduced by York in which they are described
by an advanced Vaidya metric with a fluctuating mass. Under the assumption of
spherical symmetry, we solve the equation of null outgoing rays. Then, by
neglecting the greybody factor, we calculate the late time corrections to the
s-wave contributions of the energy flux and the asymptotic spectrum. We find
three kind of modifications. Firstly, the energy flux fluctuates around its
average value with amplitudes and frequencies determined by those of the metric
fluctuations. Secondly, this average value receives two positive contributions
one of which can be reinterpreted as due to the `renormalisation' of the
surface gravity induced by the metric fluctuations. Finally, the asymptotic
spectrum is modified by the addition of terms containing thermal factors in
which the frequency of the metric fluctuations acts as a chemical potential.Comment: 27 pages, 2 figures, LaTeX. Revised versio
Nonequilibrium Evolution of Correlation Functions: A Canonical Approach
We study nonequilibrium evolution in a self-interacting quantum field theory
invariant under space translation only by using a canonical approach based on
the recently developed Liouville-von Neumann formalism. The method is first
used to obtain the correlation functions both in and beyond the Hartree
approximation, for the quantum mechanical analog of the model. The
technique involves representing the Hamiltonian in a Fock basis of annihilation
and creation operators. By separating it into a solvable Gaussian part
involving quadratic terms and a perturbation of quartic terms, it is possible
to find the improved vacuum state to any desired order. The correlation
functions for the field theory are then investigated in the Hartree
approximation and those beyond the Hartree approximation are obtained by
finding the improved vacuum state corrected up to . These
correlation functions take into account next-to-leading and
next-to-next-to-leading order effects in the coupling constant. We also use the
Heisenberg formalism to obtain the time evolution equations for the equal-time,
connected correlation functions beyond the leading order. These equations are
derived by including the connected 4-point functions in the hierarchy. The
resulting coupled set of equations form a part of infinite hierarchy of coupled
equations relating the various connected n-point functions. The connection with
other approaches based on the path integral formalism is established and the
physical implications of the set of equations are discussed with particular
emphasis on thermalization.Comment: Revtex, 32 pages; substantial new material dealing with
non-equilibrium evolution beyond Hartree approx. based on the LvN formalism,
has been adde
KELT-20b: A Giant Planet With A Period Of P ~ 3.5 Days Transiting The V ~ 7.6 Early A Star HD 185603
We report the discovery of KELT-20b, a hot Jupiter transiting a early A star, HD 185603, with an orbital period of days. Archival and follow-up photometry, Gaia parallax, radial velocities, Doppler tomography, and AO imaging were used to confirm the planetary nature of KELT-20b and characterize the system. From global modeling we infer that KELT-20 is a rapidly rotating ( ) A2V star with an effective temperature of K, mass of , radius of , surface gravity of , and age of . The planetary companion has a radius of , a semimajor axis of au, and a linear ephemeris of . We place a upper limit of on the mass of the planet. Doppler tomographic measurements indicate that the planetary orbit normal is well aligned with the projected spin axis of the star ( ). The inclination of the star is constrained to , implying a three-dimensional spin–orbit alignment of . KELT-20b receives an insolation flux of , implying an equilibrium temperature of of ∼2250 K, assuming zero albedo and complete heat redistribution. Due to the high stellar , KELT-20b also receives an ultraviolet (wavelength nm) insolation flux of , possibly indicating significant atmospheric ablation. Together with WASP-33, Kepler-13 A, HAT-P-57, KELT-17, and KELT-9, KELT-20 is the sixth A star host of a transiting giant planet, and the third-brightest host (in V ) of a transiting planet
Nonequilibrium Quantum Dynamics of Second Order Phase Transitions
We use the so-called Liouville-von Neumann (LvN) approach to study the
nonequilibrium quantum dynamics of time-dependent second order phase
transitions. The LvN approach is a canonical method that unifies the functional
Schr\"{o}dinger equation for the quantum evolution of pure states and the LvN
equation for the quantum description of mixed states of either equilibrium or
nonequilibrium. As nonequilibrium quantum mechanical systems we study a
time-dependent harmonic and an anharmonic oscillator and find the exact Fock
space and density operator for the harmonic oscillator and the nonperturbative
Gaussian Fock space and density operator for the anharmonic oscillator. The
density matrix and the coherent, thermal and coherent-thermal states are found
in terms of their classical solutions, for which the effective Hamiltonians and
equations of motion are derived. The LvN approach is further extended to
quantum fields undergoing time-dependent second order phase transitions. We
study an exactly solvable model with a finite smooth quench and find the
two-point correlation functions. Due to the spinodal instability of long
wavelength modes the two-point correlation functions lead to the
-scaling relation during the quench and the Cahn-Allen scaling
relation after the completion of quench. Further, after the finite
quench the domain formation shows a time-lag behavior at the cubic power of
quench period. Finally we study the time-dependent phase transition of a
self-interacting scalar field.Comment: discussion on back-reaction added, typos corrected, references added,
final version for PR
Far-infrared study of the Jahn-Teller distorted C60 monoanion in C60 tetraphenylphosphoniumiodide
We report high-resolution far-infrared transmission measurements on C(60)-tetraphenylphosphoniumiodide as a function of temperature. In the spectral region investigated (20-650 cm(-1)), we assign intramolecular modes of the C(60) monoanion and identify low-frequency combination modes. The well-known F(1u)(1) and F(1u)(2) modes are split into doublers at room temperature, indicating a D(5d) or D(3d) distorted ball. This result is consistent with a dynamic Jahn-Teller effect in the strong-coupling limit or with a static distortion stabilized by low-symmetry perturbations. The appearance of silent odd modes is in keeping with symmetry reduction of the hall, while activation of even modes is attributed to interband electron-phonon coupling and orientational disorder in the fulleride salt. Temperature dependences reveal a weak transition in the region 125-150 K in both C(60)(-) and counterion modes, indicating a bulk, rather than solely molecular, effect. Anomalous softening (with decreasing temperature) in several modes may correlate with the radial character of those vibrations. [S0163-1829(98)03245-7]
- …