Appropriateness of antibiotic prescription for prophylactic purposes among italian dental practitioners: Results from a cross-sectional study

The primary objective of this study was to investigate the pattern of antibiotic prescription for prophylaxis purposes among Italian DPs (dental practitioners). A nationwide cross-sectional study was conducted using a multi-stage sampling design. A structured questionnaire was used to collect socio-demographic data and information about antibiotic prophylaxis (AP) prescriptions for selected dental diagnoses and surgical procedures. The presence of an indication and appropriateness of AP were defined according to international guidelines. In total, 563 DPs answered the questionnaire (response rate 52.6%). The proportions of DPs who prescribed AP in the presence of an indication ranged from 39.1% for luxation injury with soft tissue trauma to 73.1% for dental implants, whilst DPs who prescribed AP in healthy patients ranged from 41.9% in luxation injury with soft tissue trauma to 70.3% for bone grafting. The course of AP reported by DPs was not consistent with the guidelines in 70.9% of explored procedures. A high proportion of AP prescriptions before dental procedures were unnecessary. This highlights the urgent need to incorporate recommendations for best practices into national and local protocols as soon as they are established. Specific antibiotic stewardship strategies targeted to DPs should be implemented and assessed for effectiveness in improving prescribing of antibiotics

Seismic upgrading of a historical masonry bell tower through an internal dissipative steel structure

Masonry towers are part of a valuable architectural heritage characterizing the landscape of many historical areas. These towers are vulnerable structures that are prone to earthquake damage. Hence, the design of effective seismic upgrading interventions is an important task for preserving such architectural forms for future generations. In view of that, the objective of this study is to contribute a possible addition to the portfolio of available approaches for seismic upgrading of masonry towers. This goal was pursued by exploring an innovative structural solution that does not alter the external appearance of the tower and its static scheme under gravity loads, yet is able to increase its capacity to withstand seismic actions through added damping. Specifically, the proposed solution consists of a steel structure internal to the masonry tower that incorporates fluid viscous dampers. In order to evaluate its potentialities, a real case study was taken as a testbed structure, historic analysis as well as geometric and architectural surveys were undertaken, an initial design for the upgrading was made, and numerical simulations were performed. The obtained results, although preliminary, highlight the potentialities of the proposed structural solution for the seismic upgrading of masonry towers and might open the way to future developments and applications

Quartic anomalous couplings at LEP

The search for quartic anomalous gauge couplings at LEP requires appropriate predictions for the radiative processes e+ e- \to \nu\bar\nu \gamma\gamma, e+ e- \to q\bar{q}\gamma\gamma and e+ e- \to 4 fermions+\gamma. Matrix elements are exactly computed at the tree level, and the effects of anomalous couplings and initial-state radiation are included. Comparisons with results and approximations existing in the literature are shown and commented. Improved versions of the event generators NUNUGPV and WRAP are made available for experimental analysis.Comment: LaTeX, 12 pages, 5 figures. Minor changes, version to appear in Phys. Lett.

Solution-based processing for scaffold fabrication in tissue engineering applications: A brief review

The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time-and cost-effective assets. This is necessary for easy processability, which is associated with the large range of biomaterials supporting the use of fabrication technologies. This paper presents a review of scaffold fabrication methods starting from polymer solutions that provide highly porous structures under controlled process parameters. In this review, general information of solution-based technologies, including freeze-drying, thermally or diffusion induced phase separation (TIPS or DIPS), and electrospinning, are presented, along with an overview of their technological strategies and applications. Furthermore, the differences in the fabricated constructs in terms of pore size and distribution, porosity, morphology, and mechanical and biological properties, are clarified and critically reviewed. Then, the combination of these techniques for obtaining scaffolds is described, offering the advantages of mimicking the unique architecture of tissues and organs that are intrinsically difficult to design

Mid-Late Pleistocene Neanderthal landscapes in southern Italy: Paleoecological contributions of the avian assemblage from Grotta del Cavallo, Apulia, southern Italy

We present a detailed paleoecologic analysis of avian assemblages from the Mousterian layers of the Middle Paleolithic Grotta del Cavallo site in southern Italy. Findings improve knowledge of the landscape that was exploited by Neanderthals. During the MIS 7, 6 and 3, the cave was surrounded by extensive grasslands and shrublands, locally interspersed by open woodland and rocky outcrops, whereas the coastal plain (currently underwater) hosted wetlands. Water bird taxa show an increase in population size during the cool-temperate climatic interval attributed to MIS 3, possibly linked to more humid conditions or a shorter distance between the wetland settings and the cave, compared to the previous glacial phase (MIS 6). In addition, coverage-based rarefied richness suggests higher avian diversity during MIS 3, which may reflect greater landscape heterogeneity due to the presence of wetland habitats. The tentative discovery of Branta leucopsis, together with several bird species currently found at higher altitudes, reinforces geochemically-derived palaeoclimate inferences of cooler than the present conditions. These assemblages also include the first fossil occurrence of Larus genei worldwide, the first Italian occurrence of Emberiza calandra, the oldest Italian occurrence of Podiceps nigricollis, and the occurrence of the rarely reported Sylvia cf. communis. Taphonomic analyses indicate that bone modifications are mainly due to physical syn- and post-depositional processes, and that the assemblage mainly accumulated through short-range physical transport and the feeding activities of nocturnal raptors