Signals of primordial phase transitions on CMB maps

The analysis of the CMB anisotropies is a rich source of cosmological informations. In our study, we simulated the signals produced by the relics of a first order phase transition occured during an inflationary epoch in the early Universe. These relics are bubbles of true vacuum that leave a characteristic non-Gaussian imprint on the CMB. We use different statistical estimators in order to evaluate this non-Gaussianity. We obtain some limits on the allowed values of the bubble parameters comparing our results with the experimental data. We also predict the possibility to detect this signal with the next high resolution experiments.Comment: 2 pages, submitted to Proceedings of 9th Marcel Grossmann meetin

Present limits to cosmic bubbles from the COBE-DMR three point correlation function

The existence of large scale voids in several galaxy surveys suggests the occurence of an inflationary first order phase transition. This process generates primordial bubbles that, before evolving into the present voids, leave at decoupling a non-Gaussian imprint on the CMB. I this paper we evaluate an analytical expression of the collapsed three point correlation function from the bubble temperature fluctuations. Comparing the results with COBE-DMR measures, we obtain upper limits on the allowed non-Gaussianity and hence on the bubble parameters.Comment: 4 pages, 3 figures; submitted to MNRA

Imprints of Primordial Voids on the CMB

We generalize in several ways the results existing in the literature: a) we make use of an exact general relativistic solution for a spherical, nearly empty cavity in the matter dominated era to evaluate the null geodesics and the Sachs-Wolfe effect; b) we evaluate the magnitude of the adiabatic fluctuations of the photon-baryon plasma; c) we study the influence of the shell profile; and d) we take into account the finite thickness of the last scattering surface (LSS) and the influence of its position with respect to the void center. We find empirically an analytic approximation to the Sachs-Wolfe effect for all crossing geometries and we derive an upper limit of $\approx$ 25 $h^{-1}$ Mpc for the comoving radii of voids sitting on the LSS in order to achieve compatibility with COBE's data. As a nearly empty void has an overcomoving expansion of a factor of $\approx$ 4 between decoupling and the present, the maximum allowed size at present is $\approx$ 100 $h^{-1}$ Mpc. On the other hand, the smallness of the comoving size relative to the sound horizon reduces strongly the adiabatic effect by Silk damping and makes it negligible. Most of the signature of primordial voids comes therefore from metric effects and consists of subdegree spots blue or red depending on whether the center lies beyond or within the LSS. In conclusion we refine and confirm earlier constraints on a power law void spectrum originated in an inflationary phase transition and capable of generating the observed large scale structure.Comment: 14 pages, 5 figures, submitted to Montly Notice

Understanding regional activation of thoraco-lumbar muscles in chronic low back pain and its relationship to clinically relevant domains

Background: Altered regional activation of the lumbar extensors has been previously observed in individuals with low back pain (LBP) performing high-effort and fatiguing tasks. It is currently unknown whether similar alterations can be observed during low-effort functional tasks. Similarly, previous studies did not investigate whether side differences in regional activation are present in individuals with LBP. Finally, there is limited evidence of whether the extent of the alteration of regional activation is associated with clinical factors. Therefore, the aim of this study was to investigate whether individuals with LBP exhibit asymmetric regional activation of the thoraco-lumbar extensor muscles during functional tasks, and if the extent of neuromuscular control alteration is associated with clinical and psychosocial outcome domains. Methods: 21 participants with and 21 without LBP performed five functional tasks (gait, sit-to-stand, forward trunk flexion, shoulder flexion and anterior pelvic tilt). The spatial distribution of activation of the thoraco-lumbar extensor muscles was assessed bilaterally using high-density electromyography. For each side, the distribution of electromyographic (EMG) amplitude was characterized in terms of intensity, location and size. Indices of asymmetry were calculated from these features and comparisons between groups and tasks were performed using ANOVA. The features that significantly differed between groups were correlated with self-reported measures of pain intensity and other outcome domains. Results: Indices of asymmetry did not differ between participants with and without LBP (p > 0.11). The cranio-caudal location of the activation differed between tasks (p < 0.05), but not between groups (p = 0.64). Participants with LBP showed reduced EMG amplitude during anterior pelvic tilt and loading response phase during gait (both p < 0.05). Pearson correlation revealed that greater pain intensity was associated with lower EMG amplitude for both tasks (R<-0.5, p < 0.05). Conclusions: Despite clear differences between tasks, individuals with and without LBP exhibited similar distributions of EMG amplitude during low-effort functional activities, both within and between sides. However, individuals with LBP demonstrated lower activation of the thoraco-lumbar muscles during gait and anterior pelvic tilt, especially those reporting higher pain intensity. These results have implications in the development or refinement of assessment and intervention strategies focusing on motor control in patients with chronic LBP

Formation of cosmological mass condensation within a FRW universe: exact general relativistic solutions

Within the framework of an exact general relativistic formulation of gluing manifolds, we consider the problem of matching an inhomogeneous overdense region to a Friedmann-Robertson-Walker background universe in the general spherical symmetric case of pressure-free models. It is shown that, in general, the matching is only possible through a thin shell, a fact ignored in the literature. In addition to this, in subhorizon cases where the matching is possible, an intermediate underdense region will necessarily arise.Comment: 6 page

Sufficient conditions for curvature invariants to avoid divergencies in Hyperextended Scalar Tensor theory for Bianchi models

We look for sufficient conditions such that the scalar curvature, Ricci and Kretchmann scalars be bounded in Hyperextended Scalar Tensor theory for Bianchi models. We find classes of gravitation functions and Brans-Dicke coupling functions such that the theories thus defined avoid the singularity. We compare our results with these found by Rama in the framework of the Generalised Scalar Tensor theory for the FLRW models.Comment: 13 page

Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models

Abstract In 2018 there were over 1.8 million new cases worldwide of colorectal cancer and relapses after clinical treatments. Many studies ascribe the risk of the appearance of this cancer to the Western life style : a sedentary life, obesity, and low -fiber, high -fat diets can promote the onset of disease. Several studies have shown supplement phytochemicals to have an inhibiting effect on the growth of various cancers through the activation of apoptosis. Our goal was to prove the effectiveness of a natural compound in the combined therapy of colorectal cancer. Trigno M supplement was an optimal candidate as anticancer product for its high concentrations of phenolic acids, flavonoids and anthocyanins. Our work showed the antitumor activity of Trigno M, extract of Prunus spinosa drupes combined with the nutraceutical activator complex (NAC), in 2D, 3D and in vivo colorectal cancer models. The cellular model we used both in vitro and in vivo was the HCT116 cell line, particularly suitable for engraftment after inoculation in mice. Trigno M inhibited the growth and colony formation of HCT116 cells (35%) as compared to the chemotherapy treatment with 5-fluorouracil (80%) used in clinical therapy. The reduction of the morphological dimensions in the spheroid cells after Trigno M, was compared with 5-fluorouracil demonstrating the efficacy of the Trigno M compound also in 3D models. Flow cytometric analysis on 3D cells showed a significant increase in the apoptotic cell fraction after Trigno M treatment (44.8%) and a low level of necrotic fraction (6.7%) as compared with control cells. Trigno M and 5-fluorouracil induced the apoptosis in a comparable percentage. Monotherapy with Trigno M in severely immunodeficient mice, carrying colon rectal cancer xenografts, significantly reduced tumor growth. The histopatological analysis of the ectopic tumors showed a lower level of necrosis after Trigno M treatment compared with the control. We conclude that Trigno M is well tolerated by mice, delays colorectal cancer growth in these animals and should be weighed up for integration of the current multi-drug protocols in the treatment of colon carcinoma

Cosmic microwave background: polarization and temperature anisotropies from symmetric structures

I consider the case of anisotropies in the Cosmic Microwave Background (CMB) from one single ordered perturbation source, or seed, existing well before decoupling between matter and radiation. Such structures could have been left by high energy symmetries breaking in the early universe. I focus on the cases of spherical and cylindrical symmetry of the seed. I give general analytic expressions for the polarization and temperature linear perturbations, factoring out of the Fourier integral the dependence on the photon propagation direction and on the geometric coordinates describing the seed. I show how the CMB perturbations manifestly reflect the symmetries of their seeds. CMB anisotropies are obtained with a line of sight integration. This treatment highlights the undulatory properties of the CMB. I show with numerical examples how the polarization and temperature perturbations propagate beyond the size of their seeds, reaching the CMB sound horizon at the time considered. Just like the waves from a pebble thrown in a pond, CMB anisotropy from a seed intersecting the last scattering surface appears as a series of temperature and polarization waves surrounding the seed, extending on the scale of the CMB sound horizon at decoupling, roughly $1^{o}$ in the sky. Each wave is characterized by its own value of the CMB perturbation, with the same mean amplitude of the signal coming from the seed interior. These waves could allow to distinguish relics from high energy processes of the early universe from point-like astrophysical sources, because of their angular extension and amplitude. Also, the marked analogy between polarization and temperature signals offers cross correlation possibilities for the future Planck Surveyor observations.Comment: 21 pages, seven postscript figures, final version accepted for publication in Phys.Rev.

Clumps into Voids

We consider a spherically symmetric distribution of dust and show that it is possible, under general physically reasonable conditions, for an overdensity to evolve to an underdensity (and vice versa). We find the conditions under which this occurs and illustrate it on a class of regular Lemaitre-Tolman-Bondi solutions. The existence of this phenomenon, if verified, would have the result that the topology of density contours, assumed fixed in standard structure formation theories, would have to change and that luminous matter would not trace the dark matter distribution so well.Comment: LaTeX, 17 pages, 4 figures. Submitted to GRG 20/4/200

Reconciling inflation with openness

It is already understood that the increasing observational evidence for an open Universe can be reconciled with inflation if our horizon is contained inside one single huge bubble nucleated during the inflationary phase transition. In this frame of ideas, we show here that the probability of living in a bubble with the right $\Omega_0$ (now the observations require $\Omega_0 \approx .2$) can be comparable with unity, rather than infinitesimally small. For this purpose we modify both quantitatively and qualitatively an intuitive toy model based upon fourth order gravity. As this scheme can be implemented in canonical General Relativity as well (although then the inflation driving potential must be designed entirely ad hoc), inferring from the observations that $\Omega_0 < 1$ not only does not conflict with the inflationary paradigm, but rather supports therein the occurrence of a primordial phase transition.Comment: 4 pages, one postscript figure, to be published on Physical Review D PACS: 98.80. C