Signals of primordial phase transitions on CMB maps

The analysis of the CMB anisotropies is a rich source of cosmological informations. In our study, we simulated the signals produced by the relics of a first order phase transition occured during an inflationary epoch in the early Universe. These relics are bubbles of true vacuum that leave a characteristic non-Gaussian imprint on the CMB. We use different statistical estimators in order to evaluate this non-Gaussianity. We obtain some limits on the allowed values of the bubble parameters comparing our results with the experimental data. We also predict the possibility to detect this signal with the next high resolution experiments.Comment: 2 pages, submitted to Proceedings of 9th Marcel Grossmann meetin

Imprints of Primordial Voids on the CMB

We generalize in several ways the results existing in the literature: a) we make use of an exact general relativistic solution for a spherical, nearly empty cavity in the matter dominated era to evaluate the null geodesics and the Sachs-Wolfe effect; b) we evaluate the magnitude of the adiabatic fluctuations of the photon-baryon plasma; c) we study the influence of the shell profile; and d) we take into account the finite thickness of the last scattering surface (LSS) and the influence of its position with respect to the void center. We find empirically an analytic approximation to the Sachs-Wolfe effect for all crossing geometries and we derive an upper limit of $\approx$ 25 $h^{-1}$ Mpc for the comoving radii of voids sitting on the LSS in order to achieve compatibility with COBE's data. As a nearly empty void has an overcomoving expansion of a factor of $\approx$ 4 between decoupling and the present, the maximum allowed size at present is $\approx$ 100 $h^{-1}$ Mpc. On the other hand, the smallness of the comoving size relative to the sound horizon reduces strongly the adiabatic effect by Silk damping and makes it negligible. Most of the signature of primordial voids comes therefore from metric effects and consists of subdegree spots blue or red depending on whether the center lies beyond or within the LSS. In conclusion we refine and confirm earlier constraints on a power law void spectrum originated in an inflationary phase transition and capable of generating the observed large scale structure.Comment: 14 pages, 5 figures, submitted to Montly Notice

Understanding regional activation of thoraco-lumbar muscles in chronic low back pain and its relationship to clinically relevant domains

Background: Altered regional activation of the lumbar extensors has been previously observed in individuals with low back pain (LBP) performing high-effort and fatiguing tasks. It is currently unknown whether similar alterations can be observed during low-effort functional tasks. Similarly, previous studies did not investigate whether side differences in regional activation are present in individuals with LBP. Finally, there is limited evidence of whether the extent of the alteration of regional activation is associated with clinical factors. Therefore, the aim of this study was to investigate whether individuals with LBP exhibit asymmetric regional activation of the thoraco-lumbar extensor muscles during functional tasks, and if the extent of neuromuscular control alteration is associated with clinical and psychosocial outcome domains. Methods: 21 participants with and 21 without LBP performed five functional tasks (gait, sit-to-stand, forward trunk flexion, shoulder flexion and anterior pelvic tilt). The spatial distribution of activation of the thoraco-lumbar extensor muscles was assessed bilaterally using high-density electromyography. For each side, the distribution of electromyographic (EMG) amplitude was characterized in terms of intensity, location and size. Indices of asymmetry were calculated from these features and comparisons between groups and tasks were performed using ANOVA. The features that significantly differed between groups were correlated with self-reported measures of pain intensity and other outcome domains. Results: Indices of asymmetry did not differ between participants with and without LBP (p > 0.11). The cranio-caudal location of the activation differed between tasks (p < 0.05), but not between groups (p = 0.64). Participants with LBP showed reduced EMG amplitude during anterior pelvic tilt and loading response phase during gait (both p < 0.05). Pearson correlation revealed that greater pain intensity was associated with lower EMG amplitude for both tasks (R<-0.5, p < 0.05). Conclusions: Despite clear differences between tasks, individuals with and without LBP exhibited similar distributions of EMG amplitude during low-effort functional activities, both within and between sides. However, individuals with LBP demonstrated lower activation of the thoraco-lumbar muscles during gait and anterior pelvic tilt, especially those reporting higher pain intensity. These results have implications in the development or refinement of assessment and intervention strategies focusing on motor control in patients with chronic LBP

Sufficient conditions for curvature invariants to avoid divergencies in Hyperextended Scalar Tensor theory for Bianchi models

We look for sufficient conditions such that the scalar curvature, Ricci and Kretchmann scalars be bounded in Hyperextended Scalar Tensor theory for Bianchi models. We find classes of gravitation functions and Brans-Dicke coupling functions such that the theories thus defined avoid the singularity. We compare our results with these found by Rama in the framework of the Generalised Scalar Tensor theory for the FLRW models.Comment: 13 page

Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models

Abstract In 2018 there were over 1.8 million new cases worldwide of colorectal cancer and relapses after clinical treatments. Many studies ascribe the risk of the appearance of this cancer to the Western life style : a sedentary life, obesity, and low -fiber, high -fat diets can promote the onset of disease. Several studies have shown supplement phytochemicals to have an inhibiting effect on the growth of various cancers through the activation of apoptosis. Our goal was to prove the effectiveness of a natural compound in the combined therapy of colorectal cancer. Trigno M supplement was an optimal candidate as anticancer product for its high concentrations of phenolic acids, flavonoids and anthocyanins. Our work showed the antitumor activity of Trigno M, extract of Prunus spinosa drupes combined with the nutraceutical activator complex (NAC), in 2D, 3D and in vivo colorectal cancer models. The cellular model we used both in vitro and in vivo was the HCT116 cell line, particularly suitable for engraftment after inoculation in mice. Trigno M inhibited the growth and colony formation of HCT116 cells (35%) as compared to the chemotherapy treatment with 5-fluorouracil (80%) used in clinical therapy. The reduction of the morphological dimensions in the spheroid cells after Trigno M, was compared with 5-fluorouracil demonstrating the efficacy of the Trigno M compound also in 3D models. Flow cytometric analysis on 3D cells showed a significant increase in the apoptotic cell fraction after Trigno M treatment (44.8%) and a low level of necrotic fraction (6.7%) as compared with control cells. Trigno M and 5-fluorouracil induced the apoptosis in a comparable percentage. Monotherapy with Trigno M in severely immunodeficient mice, carrying colon rectal cancer xenografts, significantly reduced tumor growth. The histopatological analysis of the ectopic tumors showed a lower level of necrosis after Trigno M treatment compared with the control. We conclude that Trigno M is well tolerated by mice, delays colorectal cancer growth in these animals and should be weighed up for integration of the current multi-drug protocols in the treatment of colon carcinoma

Cosmic microwave background: polarization and temperature anisotropies from symmetric structures

I consider the case of anisotropies in the Cosmic Microwave Background (CMB) from one single ordered perturbation source, or seed, existing well before decoupling between matter and radiation. Such structures could have been left by high energy symmetries breaking in the early universe. I focus on the cases of spherical and cylindrical symmetry of the seed. I give general analytic expressions for the polarization and temperature linear perturbations, factoring out of the Fourier integral the dependence on the photon propagation direction and on the geometric coordinates describing the seed. I show how the CMB perturbations manifestly reflect the symmetries of their seeds. CMB anisotropies are obtained with a line of sight integration. This treatment highlights the undulatory properties of the CMB. I show with numerical examples how the polarization and temperature perturbations propagate beyond the size of their seeds, reaching the CMB sound horizon at the time considered. Just like the waves from a pebble thrown in a pond, CMB anisotropy from a seed intersecting the last scattering surface appears as a series of temperature and polarization waves surrounding the seed, extending on the scale of the CMB sound horizon at decoupling, roughly $1^{o}$ in the sky. Each wave is characterized by its own value of the CMB perturbation, with the same mean amplitude of the signal coming from the seed interior. These waves could allow to distinguish relics from high energy processes of the early universe from point-like astrophysical sources, because of their angular extension and amplitude. Also, the marked analogy between polarization and temperature signals offers cross correlation possibilities for the future Planck Surveyor observations.Comment: 21 pages, seven postscript figures, final version accepted for publication in Phys.Rev.

Clumps into Voids

We consider a spherically symmetric distribution of dust and show that it is possible, under general physically reasonable conditions, for an overdensity to evolve to an underdensity (and vice versa). We find the conditions under which this occurs and illustrate it on a class of regular Lemaitre-Tolman-Bondi solutions. The existence of this phenomenon, if verified, would have the result that the topology of density contours, assumed fixed in standard structure formation theories, would have to change and that luminous matter would not trace the dark matter distribution so well.Comment: LaTeX, 17 pages, 4 figures. Submitted to GRG 20/4/200

Evolution of radial profiles in regular Lemaitre-Tolman-Bondi dust models

We undertake a comprehensive and rigorous analytic study of the evolution of radial profiles of covariant scalars in regular Lemaitre-Tolman-Bondi dust models. We consider specifically the phenomenon of "profile inversions" in which an initial clump profile of density, spatial curvature or the expansion scalar, might evolve into a void profile (and vice versa). Previous work in the literature on models with density void profiles and/or allowing for density profile inversions is given full generalization, with some erroneous results corrected. We prove rigorously that if an evolution without shell crossings is assumed, then only the 'clump to void' inversion can occur in density profiles, and only in hyperbolic models or regions with negative spatial curvature. The profiles of spatial curvature follow similar patterns as those of the density, with 'clump to void' inversions only possible for hyperbolic models or regions. However, profiles of the expansion scalar are less restrictive, with profile inversions necessarily taking place in elliptic models. We also examine radial profiles in special LTB configurations: closed elliptic models, models with a simultaneous big bang singularity, as well as a locally collapsing elliptic region surrounded by an expanding hyperbolic background. The general analytic statements that we obtain allow for setting up the right initial conditions to construct fully regular LTB models with any specific qualitative requirements for the profiles of all scalars and their time evolution. The results presented can be very useful in guiding future numerical work on these models and in revising previous analytic work on all their applications.Comment: Final version to appear in Classical and Quantum Gravity. Readers eager to know the results and implications without having to go through the technical detail are recommended to go directly to the summary and discussion in the final section (section 11). Typos have been corrected and an important reference has been adde

Graviton Spectra in String Cosmology

We propose to uncover the signature of a stringy era in the primordial Universe by searching for a prominent peak in the relic graviton spectrum. This feature, which in our specific model terminates an $\omega^3$ increase and initiates an $\omega^{-7}$ decrease, is induced during the so far overlooked bounce of the scale factor between the collapsing deflationary era (or pre-Big Bang) and the expanding inflationary era (or post-Big Bang). We evaluate both analytically and numerically the frequency and the intensity of the peak and we show that they may likely fall in the realm of the new generation of interferometric detectors. The existence of a peak is at variance with ordinarily monotonic (either increasing or decreasing) graviton spectra of canonical cosmologies; its detection would therefore offer strong support to string cosmology.Comment: 14 pages, RevTex source and 6 figures.p

Low-Temperature Sintering of Alumina with Liquid-Forming Additives

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66046/1/j.1151-2916.1991.tb07825.x.pd