Structure of the hadron-quark mixed phase in protoneutron stars

We study the hadron-quark phase transition in the interior of hot protoneutron stars, combining the Brueckner-Hartree-Fock approach for hadronic matter with the MIT bag model or the Dyson-Schwinger model for quark matter. We examine the structure of the mixed phase constructed according to different prescriptions for the phase transition, and the resulting consequences for stellar properties. We find important effects for the internal composition, but only very small influence on the global stellar properties.Comment: 6 pages, 4 figure

Numerical Investigations on Changes of the Main Shear Plane while Broaching

AbstractThe quality of broached components can be influenced by different factors, such as am-bient temperatures, human factors or vibrations of the machine structure induced by process-machine-interactions. These vibrations are normally initiated by changing pro-cess forces, which are mainly caused by cutting thickness or rake angle variations. Broached components are produced within one motion of the broach along the surface of the work piece, where multiple teeth in a row are in contact. The variation of the cut- ting thickness results from a wavy profile on the surface generated by the previous cut-ting process or the previous tooth. When the cutting thickness changes during the process, the rake angle varies, too. In some further published works, the changing cutting thickness and the changing rake angle during broaching were investigated by means of machining simulations with the result that the process forces are still adjusting after the cutting thickness and the rake angle have already reached a stable value. The adjustment of the shear plane on the new cutting conditions is mentioned as the main reason. This paper presents some deeper investigations on this effect. Therefore, 2D machining simulations for different cutting thicknesses and cutting velocities are performed. The investigations show tendencies for the still adjusting shear plane after changing the cutting thickness or the rake angle during the cutting process. Finally, the simulation results are validated with experimentally observed data

Hybrid protoneutron stars with the MIT bag model

We study the hadron-quark phase transition in the interior of protoneutron stars. For the hadronic sector, we use a microscopic equation of state involving nucleons and hyperons derived within the finite-temperature Brueckner-Bethe-Goldstone many-body theory, with realistic two-body and three-body forces. For the description of quark matter, we employ the MIT bag model both with a constant and a density-dependent bag parameter. We calculate the structure of protostars with the equation of state comprising both phases and find maximum masses below 1.6 solar masses. Metastable heavy hybrid protostars are not found.Comment: 12 pages, 9 figures submitted to Phys. Rev.

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal.

Proteins involved in lipoprotein metabolism can modulate cardiovascular health. While often measured to assess adult metabolic diseases, little is known about the proteomes of lipoproteins and their relation to metabolic dysregulation and underlying inflammation in undernourished child populations. The objective of this population study was to globally characterize plasma proteins systemically associated with HDL, LDL, and triglycerides in 500 Nepalese children. Abnormal lipid profiles characterized by elevated plasma triglycerides and low HDL-cholesterol (HDL-C) concentrations were common, especially in children with subclinical inflammation. Among 982 proteins analyzed, the relative abundance of 11, 12, and 52 plasma proteins was correlated with LDL-cholesterol (r = -0.43∼0.70), triglycerides (r = -0.39∼0.53), and HDL-C (r = -0.49∼0.79) concentrations, respectively. These proteins included apolipoproteins and numerous unexpected intracellular and extracellular matrix binding proteins, likely originating in hepatic and peripheral tissues. Relative abundance of two-thirds of the HDL proteome varied with inflammation, with acute phase reactants higher by 4∼40%, and proteins involved in HDL biosynthesis, cholesterol efflux, vitamin transport, angiogenesis, and tissue repair lower by 3∼20%. Untargeted plasma proteomics detects comprehensive sets of both known and novel lipoprotein-associated proteins likely reflecting systemic regulation of lipoprotein metabolism and vascular homeostasis. Inflammation-altered distributions of the HDL proteome may be predisposing undernourished populations to early chronic disease

Microscopic structure of a vortex line in superfluid neutron star matter

The microscopic structure of an isolated vortex line in superfluid neutron star matter is studied by solving the Bogoliubov-de Gennes equations. Our calculation, which is the starting point for a microscopic calculation of pinning forces in neutron stars, shows that the size of the vortex core varies differently with density, and is in general smaller than assumed in some earlier calculations of vortex pinning in neutron star crusts. The implications of this result are discussedComment: 5 pages, 2 figure

Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures

Background: Mental health disorders in the child and adolescent population are a pressing public health concern. Despite the high prevalence of psychopathology in this vulnerable population, the transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) has many obstacles such as deficiencies in planning, organisational readiness and policy gaps. All these factors contribute to an inadequate and suboptimal transition process. A suite of measures is required that would allow young people to be assessed in a structured and standardised way to determine the on-going need for care and to improve communication across clinicians at CAMHS and AMHS. This will have the potential to reduce the overall health economic burden and could also improve the quality of life for patients travelling across the transition boundary. The MILESTONE (Managing the Link and Strengthening Transition from Child to Adult Mental Health Care) project aims to address the significant socioeconomic and societal challenge related to the transition process. This protocol paper describes the development of two MILESTONE transition-related measures: The Transition Readiness and Appropriateness Measure (TRAM), designed to be a decision-making aide for clinicians, and the Transition Related Outcome Measure (TROM), for examining the outcome of transition. Methods: The TRAM and TROM have been developed and were validated following the US FDA Guidance for Patient-reported Outcome Measures which follows an incremental stepwise framework. The study gathers information from service users, parents, families and mental health care professionals who have experience working with young people undergoing the transition process from eight European countries. Discussion: There is an urgent need for comprehensive measures that can assess transition across the CAMHS/AMHS boundary. This study protocol describes the process of development of two new transition measures: the TRAM and TROM. The TRAM has the potential to nurture better transitions as the findings can be summarised and provided to clinicians as a clinician-decision making support tool for identifying cases who need to transition and the TROM can be used to examine the outcomes of the transition process. Trial registration: MILESTONE study registration: ISRCTN83240263 Registered 23-July-2015 - ClinicalTrials.gov NCT03013595 Registered 6 January 2017

State-wide calculation of terrain-visualisations and automatic map generation for archaeological objects

Airborne laser scanning (ALS) became very popular in the last two decades for archaeological prospection. With the state-wide availability of ALS-data in Lower Saxony, Germany, about 48,000 km2;, we needed flexible and scalable approaches to process the data. First, we produced a state-wide digital terrain model (DTM) and some visualisations of it to use it in standard GIS software. Some of these visualisations are available as web maps and used for prospection also by volunteers. In a second approach, we automatically generate maps for all known archaeological objects. This is mainly used for the documentation of the 130,000 known objects in Lower Saxony, but also for object-by-object revision of the database. These Maps will also be presented in the web portal "Denkmalatlas Niedersachsen", an open data imitative of the state Lower Saxony.In the first part of this paper, we show how the state-wide DTM and its visualisations can be calculated using tiles. In the second part, we describe the automatic map generation process. All implementations were done with ArcGIS and its scripting interface ArcPy

Analysis of microsatellite instability in colorectal carcinoma by microfluidic-based chip electrophoresis

Microsatellite analysis is an important tool in clinical research and molecular diagnostics because microsatellite instability (MSI) occurs frequently in various types of cancer. Approximately 10–15% of colorectal, gastric and endometrial carcinomas are associated with MSI, and this has an impact on clinical prognosis. The microsatellite loci Bat25, Bat26, D2S123, D5S346 and D17S250, recommended by the Bethesda guidelines, were analysed by microfluidic-based on-chip electrophoresis in 40 cases of colon carcinoma with known MSI status. In all cases, microfluidic separation of the PCR amplicons resulted in highly resolved, distinct patterns of each of the five microsatellite loci. Detection of MSI could be demonstrated by microsatellite-loci-associated, well-defined deviations in the electropherogram profiles of tumour and non-tumour material, and confirmed the classification of MSI cases performed by conventional technology. In conclusion, microfluidic chip technology is a simple and reliable approach for MSI detection that allows label-free and very fast analysis of microsatellite amplicons