Immune dysregulation in myelodysplastic syndrome

Myelodysplastic syndrome (MDS) represents one of the most challenging health-related problems in the elderly. Characterized by dysplastic morphology in the bone marrow in association with ineffective hematopoiesis, pathophysiological causes of this disease are diverse including genetic abnormalities within myeloid progenitors, altered epigenetics, and changes in the bone marrow microenvironment. The concept that T-cell mediated autoimmunity contributes to bone marrow failure has been widely accepted due to hematologic improvement after immunosuppressive therapy (IST) in a subset of patients. Currently, IST for MDS primarily involves anti-thymocyte globulin (ATG)-based regimens in which responsiveness is strongly associated with younger (under 60 years) age at disease onset. In such cases, progressive cytopenia may occur as a consequence of expanded self-reactive CD8+ cytotoxic T lymphocytes (CTLs) that suppress hematopoietic progenitors. Although most hematologists agree that IST can offer durable hematologic remission in younger patients with MDS, an international clinical study and a better understanding of the molecular mechanisms contributing to the expansion of self-reactive CTLs is crucial. In this review, data accumulated in the US, Europe, and Asia will be summarized to provide insight and direction for a multi-center international trial

Phases and geometry of the N=1 A_2 quiver gauge theory and matrix models

We study the phases and geometry of the N=1 A_2 quiver gauge theory using matrix models and a generalized Konishi anomaly. We consider the theory both in the Coulomb and Higgs phases. Solving the anomaly equations, we find that a meromorphic one-form sigma(z)dz is naturally defined on the curve Sigma associated to the theory. Using the Dijkgraaf-Vafa conjecture, we evaluate the effective low-energy superpotential and demonstrate that its equations of motion can be translated into a geometric property of Sigma: sigma(z)dz has integer periods around all compact cycles. This ensures that there exists on Sigma a meromorphic function whose logarithm sigma(z)dz is the differential. We argue that the surface determined by this function is the N=2 Seiberg-Witten curve of the theory.Comment: 41 pages, 2 figures, JHEP style. v2: references adde

On narrowing coated conductor film: emergence of granularity-induced field hysteresis of transport critical current

Critical current density Jc in polycrystalline or granular superconducting material is known to be hysteretic with applied field H due to the focusing of field within the boundary between adjacent grains. This is of concern in the so-called coated conductors wherein superconducting film is grown on a granular, but textured surface of a metal substrate. While previous work has mainly been on Jc determined using induced or magnetization currents, the present work utilizes transport current via an applied potential in strip geometry. It is observed that the effect is not as pronounced using transport current, probably due to a large difference in criterion voltage between the two types of measurements. However, when the films are narrowed by patterning into 200-, 100-, or 80-micron, the hysteresis is clearly seen, because of the forcing of percolation across higher-angle grain boundaries. This effect is compared for films grown on ion-beam-assisted-deposited (IBAD) YSZ substrate and those grown on rolling-assisted-biaxially-textures substrates (RABiTS) which have grains that are about ten times larger. The hysteresis is more pronounced for the latter, which is more likely to have a weak grain boundary spanning the width of the microbridge. This is also of concern to applications in which coated conductors will be striated in order to reduce of AC losses.Comment: text-only: 10 pages, plus 5 figures on 5 page

Judgment Aggregation with Abstentions under Voters' Hierarchy

International audienceSimilar to Arrow’s impossibility theorem for preference aggregation, judgment aggregation has also an intrinsic impossibility for generating consistent group judgment from individual judgments. Removing some of the pre-assumed conditions would mitigate the problem but may still lead to too restrictive solutions. It was proved that if completeness is removed but other plausible conditions are kept, the only possible aggregation functions are oligarchic, which means that the group judgment is purely determined by a certain subset of participating judges. Instead of further challenging the other conditions, this paper investigates how the judgment from each individual judge affects the group judgment in an oligarchic environment. We explore a set of intuitively demanded conditions under abstentions and design a feasible judgment aggregation rule based on the agents’ hierarchy. We show this proposed aggregation rule satisfies the desirable conditions. More importantly, this rule is oligarchic with respect to a subset of agenda instead of the whole agenda due to its literal-based characteristics

Rebate Rules in Threshold Public Good Provision

This paper considers how six alternative rebate rules affect voluntary contributions in a threshold public-good experiment. The rules differ by (1) whether an individual can receive a proportional rebate of excess contributions, a winner-takes-all of any excess contributions, or a full rebate of one's contribution in the event the public good is provided and excess contributions exist, and (2) whether the probability of receiving a rebate is proportional to an individual's contribution relative to total contributions or is a simple uniform probability distribution set by the number of contributors. The paper adds to the existing experimental economics literature on threshold public goods by investigating both aggregate and individual demand revelation under the winner-take-all and random full-rebate rules. Half of the rules (proportional rebate, winner-take-all with uniform probability among all group members, and random full-rebate with uniform probability) provide total contributions that nearly equal total benefits, while the rest (winner-take-all with proportional probability, winner-take-all with uniform probability among contributors only, and random full-rebate with proportional probability) exceed benefits by over 30 percent. Only the proportional rebate rule is found to achieve both aggregate and individual demand revelation. Our experimental results have implications for both fundraisers and valuation practitioners.

Empirical Implementation of Nonparametric First-Price Auction Models

Nonparametric estimators provide a flexible means of uncovering salient features of auction data. Although these estimators are popular in the literature, many key features necessary for proper implementation have yet to be uncovered. Here we provide several suggestions for nonparamteric estimation of first-price auction models. Specifically, we show how to impose monotonicity of the equilibrium bidding strategy; a key property of structural auction models not guaranteed in standard nonparametric estimation. We further develop methods for automatic bandwidth selection. Finally, we discuss how to impose monotonicity in auctions with differering number of bidders, reserve prices, and auction-specific characteristics. Finite sample performance is examined using simulated data as well as experimental auction data.

Robust Newton solver based on variable switch for a finite volume discretization of Richards equation

International audienceWe propose an efficient nonlinear solver for the resolution of the Richards equation. It is based on variable switching and is easily implemented thanks to a fictitious variable allowing to describe both the saturation and the pressure. Numerical experiments show that our method enables to use Newton's method with large time steps, reasonable number of iterations and in regions where the pressure-saturation relationship is given by a graph

Lattice supersymmetry, superfields and renormalization

We study Euclidean lattice formulations of non-gauge supersymmetric models with up to four supercharges in various dimensions. We formulate the conditions under which the interacting lattice theory can exactly preserve one or more nilpotent anticommuting supersymmetries. We introduce a superfield formalism, which allows the enumeration of all possible lattice supersymmetry invariants. We use it to discuss the formulation of Q-exact lattice actions and their renormalization in a general manner. In some examples, one exact supersymmetry guarantees finiteness of the continuum limit of the lattice theory. As a consequence, we show that the desired quantum continuum limit is obtained without fine tuning for these models. Finally, we discuss the implications and possible further applications of our results to the study of gauge and non-gauge models.Comment: 44 pages, 1 figur