Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/1 (to J.J.R.), Program GrantG09000554 (to S.O.R)], The Wellcome Trust [078986/Z/06/Z (to S.O.R.)], the MRC Centre for Obesity and Related Metabolic Disorders (MRC-CORD) [GO600717] and the NIHR Comprehensive Biomedical Research Centre [CG50826].Peer reviewedPublisher PD

Recursive relations for a quiver gauge theory

We study the recursive relations for a quiver gauge theory with the gauge group $SU(N_1)\times SU(N_2)$ with bifundamental fermions transforming as $(N_1,\bar{N_2})$. We work out the recursive relation for the amplitudes involving a pair of quark and antiquark and gluons of each gauge group. We realize directly in the recursive relations the invariance under the order preserving permutations of the gluons of the first and the second gauge group. We check the proposed relations for MHV, 6-point and 7-point amplitudes and find the agreements with the known results and the known relations with the single gauge group amplitudes. The proposed recursive relation is much more efficient in calculating the amplitudes than using the known relations with the amplitudes of the single gauge group.Comment: 33 pages and 2 figures, minor correction

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms

Peer reviewedPublisher PD

Constraints on explosive silicon burning in core-collapse supernovae from measured Ni/Fe ratios

Measurements of explosive nucleosynthesis yields in core-collapse supernovae provide tests for explosion models. We investigate constraints on explosive conditions derivable from measured amounts of nickel and iron after radioactive decays using nucleosynthesis networks with parameterized thermodynamic trajectories. The Ni/Fe ratio is for most regimes dominated by the production ratio of 58Ni/(54Fe + 56Ni), which tends to grow with higher neutron excess and with higher entropy. For SN 2012ec, a supernova that produced a Ni/Fe ratio of $3.4\pm1.2$ times solar, we find that burning of a fuel with neutron excess $\eta \approx 6\times 10^{-3}$ is required. Unless the progenitor metallicity is over 5 times solar, the only layer in the progenitor with such a neutron excess is the silicon shell. Supernovae producing large amounts of stable nickel thus suggest that this deep-lying layer can be, at least partially, ejected in the explosion. We find that common spherically symmetric models of $M_{\rm ZAMS} \lesssim 13$ Msun stars exploding with a delay time of less than one second ($M_{\rm cut} < 1.5$ Msun) are able to achieve such silicon-shell ejection. Supernovae that produce solar or sub-solar Ni/Fe ratios, such as SN 1987A, must instead have burnt and ejected only oxygen-shell material, which allows a lower limit to the mass cut to be set. Finally, we find that the extreme Ni/Fe value of 60-75 times solar derived for the Crab cannot be reproduced by any realistic-entropy burning outside the iron core, and neutrino-neutronization obtained in electron-capture models remains the only viable explanation.Comment: 13 pages, 9 figures, accepted for publication in Ap

B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis

<div><p>Recent success with B cell depletion therapies has revitalized efforts to understand the pathogenic role of B cells in Multiple Sclerosis (MS). Using the adoptive transfer system of experimental autoimmune encephalomyelitis (EAE), a murine model of MS, we have previously shown that mice in which B cells are the only MHCII-expressing antigen presenting cell (APC) are susceptible to EAE. However, a reproducible delay in the day of onset of disease driven by exclusive B cell antigen presentation suggests that B cells require optimal conditions to function as APCs in EAE. In this study, we utilize an <i>in vivo</i> genetic system to conditionally and temporally regulate expression of MHCII to test the hypothesis that B cell APCs mediate attenuated and delayed neuroinflammatory T cell responses during EAE. Remarkably, induction of MHCII on B cells following the transfer of encephalitogenic CD4 T cells induced a rapid and robust form of EAE, while no change in the time to disease onset occurred for recipient mice in which MHCII is induced on a normal complement of APC subsets. Changes in CD4 T cell activation over time did not account for more rapid onset of EAE symptoms in this new B cell-mediated EAE model. Our system represents a novel model to study how the timing of pathogenic cognate interactions between lymphocytes facilitates the development of autoimmune attacks within the CNS.</p></div

Minimax optimization of entanglement witness operator for the quantification of three-qubit mixed-state entanglement

We develop a numerical approach for quantifying entanglement in mixed quantum states by convex-roof entanglement measures, based on the optimal entanglement witness operator and the minimax optimization method. Our approach is applicable to general entanglement measures and states and is an efficient alternative to the conventional approach based on the optimal pure-state decomposition. Compared with the conventional one, it has two important merits: (i) that the global optimality of the solution is quantitatively verifiable, and (ii) that the optimization is considerably simplified by exploiting the common symmetry of the target state and measure. To demonstrate the merits, we quantify Greenberger-Horne-Zeilinger (GHZ) entanglement in a class of three-qubit full-rank mixed states composed of the GHZ state, the W state, and the white noise, the simplest mixtures of states with different genuine multipartite entanglement, which have not been quantified before this work. We discuss some general properties of the form of the optimal witness operator and of the convex structure of mixed states, which are related to the symmetry and the rank of states

Time-stepping beyond CFL: a locally one-dimensional scheme for acoustic wave propagation

In this abstract, we present a case study in the application of a time-stepping method, unconstrained by the CFL condition, for computational acoustic wave propagation in the context of full waveform inversion. The numerical scheme is a locally one-dimensional (LOD) variant of alternating dimension implicit (ADI) method. The LOD method has a maximum time step that is restricted only by the Nyquist sampling rate. The advantage over traditional explicit time-stepping methods occurs in the presence of high contrast media, low frequencies, and steep, narrow perfectly matched layers (PML). The main technical point of the note, from a numerical analysis perspective, is that the LOD scheme is adapted to the presence of a PML. A complexity study is presented and an application to full waveform inversion is shown.National Science Foundation (U.S.); Alfred P. Sloan Foundatio

Quantum states in a magnetic anti-dot

We study a new system in which electrons in two dimensions are confined by a non homogeneous magnetic field. The system consists of a heterostructure with on top of it a superconducting disk. We show that in this system electrons can be confined into a dot region. This magnetic anti-dot has the interesting property that the filling of the dot is a discrete function of the magnetic field. The circulating electron current inside and outside the anti-dot can be in opposite direction for certain bound states. And those states exhibit a diamagnetic to paramagnetic transition with increasing magnetic field. The absorption spectrum consists of many peaks, some of which violate Kohn's theorem, and which is due to the coupling of the center of mass motion with the other degrees of freedom.Comment: 6 pages, 12 ps figure

Precise determination of equilibrium sulfur isotope effects during volatilization and deprotonation of dissolved H_2S

Sulfide (H_2S, HS^−, and S^(2−)) is ubiquitous in marine porewaters as a result of microbial sulfate reduction, constituting the reductive end of the biogeochemical sulfur cycle. Stable isotopes have been widely used to constrain the sulfur cycle, because the redox transformations of sulfur compounds, such as microbial sulfate reduction, often exhibit sizable kinetic isotope effects. In contrast to sulfate ion (SO_4^(2−)), the most abundant form of dissolved sulfur in seawater, H2S is volatile and also deprotonated at near neutral pH. Equilibrium isotope partitioning between sulfide species can therefore overlap with kinetic isotope effects during reactions involving sulfide as either reactant or intermediate. Previous experimental attempts to measure equilibrium fractionation between H_2S and HS− have reached differing results, likely due to solutions of widely varying ionic strength. In this study, we measured the sulfur isotope fractionation between total dissolved sulfide and gaseous H2S at 20.6 ± 0.5 °C over the pH range from 2 to 8, and calculated the equilibrium isotope effects associated with deprotonation of dissolved H_2S. By using dilute solutions of Na2S, made possible by the improved sensitivity of mass spectrometric techniques, uncertainty in the first dissociation constant of H2S due to ionic strength could be better controlled. This in turn allowed us to close sulfur isotope mass balance for our experiments and increase the accuracy of the estimated fractionation factor. At equilibrium, aqueous H2S was enriched in ^(34)S by 0.7‰ and 3.1‰ relative to gaseous H_2S and aqueous HS−, respectively. The estimated fractionation between aqueous H_2S and HS^− lies between two earlier experimental reports, but agrees within the uncertainty of the measurements with a recent theoretical calculation

Deflagrations in hybrid CONe white dwarfs: a route to explain the faint Type Iax supernova 2008ha

Stellar evolution models predict the existence of hybrid white dwarfs (WDs) with a carbon-oxygen core surrounded by an oxygen-neon mantle. Being born with masses ~1.1 Msun, hybrid WDs in a binary system may easily approach the Chandrasekhar mass (MCh) by accretion and give rise to a thermonuclear explosion. Here, we investigate an off-centre deflagration in a near-MCh hybrid WD under the assumption that nuclear burning only occurs in carbon-rich material. Performing hydrodynamics simulations of the explosion and detailed nucleosynthesis post-processing calculations, we find that only 0.014 Msun of material is ejected while the remainder of the mass stays bound. The ejecta consist predominantly of iron-group elements, O, C, Si and S. We also calculate synthetic observables for our model and find reasonable agreement with the faint Type Iax SN 2008ha. This shows for the first time that deflagrations in near-MCh WDs can in principle explain the observed diversity of Type Iax supernovae. Leaving behind a near-MCh bound remnant opens the possibility for recurrent explosions or a subsequent accretion-induced collapse in faint Type Iax SNe, if further accretion episodes occur. From binary population synthesis calculations, we find the rate of hybrid WDs approaching MCh to be on the order of 1 percent of the Galactic SN Ia rate.Comment: 9 pages, 7 figures, 2 tables, accepted for publication in MNRA