Resistance of a delta wing in a supersonic flow

The resistance of a delta wing at small angle of attack in supersonic conical flow with its leading edges within the Mach cone is calculated by a method that separates out the suction force

PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1.

Anion exchanger 1 (AE1) mediates Cl-/HCO3- exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. AE1's C-terminal tail (AE1C) contains multiple potential membrane targeting/retention determinants, including a predicted PDZ binding motif, which are critical for its normal membrane residency. Here we identify PDLIM5 as a direct binding partner for AE1 in human kidney, via PDLIM5's PDZ domain and the PDZ binding motif in AE1C. Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex in which PDLIM5 provides a bridge between ILK and AE1C. Depletion of PDLIM5 resulted in significant reduction in kAE1 at the cell membrane, whereas over-expression of kAE1 was accompanied by increased PDLIM5 levels, underscoring the functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kAE1 and actin cytoskeleton-associated proteins in polarized cells.This work was supported by the Wellcome Trust (grant ref: 088489/Z/09/Z and Strategic award 100140/Z/12/Z to the Cambridge Institute for Medical Research), and the British Heart Foundation (grant ref: SBAG/120). The Addenbrooke's Human Research Tissue Bank is supported by the NIHR Cambridge Biomedical Research Centre.This is the final version of the article. It first appeared from Nature Publishing Group via https://doi.org/10.1038/srep3970

Fast, Linear Time, m-Adic Hierarchical Clustering for Search and Retrieval using the Baire Metric, with linkages to Generalized Ultrametrics, Hashing, Formal Concept Analysis, and Precision of Data Measurement

We describe many vantage points on the Baire metric and its use in clustering data, or its use in preprocessing and structuring data in order to support search and retrieval operations. In some cases, we proceed directly to clusters and do not directly determine the distances. We show how a hierarchical clustering can be read directly from one pass through the data. We offer insights also on practical implications of precision of data measurement. As a mechanism for treating multidimensional data, including very high dimensional data, we use random projections.Comment: 17 pages, 45 citations, 2 figure

How fast do gully headcuts retreat?

© 2016 Elsevier B.V. Gully erosion has important on and off site effects. Therefore, several studies have been conducted over the past decades to quantify gully headcut retreat (GHR) in different environments. Although these led to important site-specific and regional insights, the overall importance of this erosion process or the factors that control it at a global scale remain poorly understood. This study aims to bridge this gap by reviewing research on GHR and conducting a meta-analysis of measured GHR rates worldwide. Through an extensive literature review, GHR rates for 933 individual and actively retreating gullies have been compiled from more than 70 study areas worldwide (comprising a total measuring period of >19 600 years). Each GHR rate was measured through repeated field surveys and/or analyses of aerial photographs over a period of at least one year (maximum: 97 years, median: 17 years). The data show a very large variability, both in terms of gully dimensions (cross-sectional areas ranging between 0.11 and 816 m2 with a median of 4 m2) and volumetric GHR rates (ranging between 0.002 and 47 430 m3 year- 1 with a median of 2.2 m3 year- 1). Linear GHR rates vary between 0.01 and 135 m year- 1 (median: 0.89 m year- 1), while areal GHR rates vary between 0.01 and 3628 m2 year- 1 (median: 3.12 m2 year- 1). An empirical relationship allows estimating volumetric retreat rates from areal retreat rates with acceptable uncertainties. By means of statistical analyses for a subset of 724 gullies with a known contributing area, we explored the factors most relevant in explaining the observed 7 orders of magnitudes of variation in volumetric GHR rates. Results show that measured GHR rates are significantly correlated to the runoff contributing area of the gully (r2 = 0.15) and the rainy day normal (RDN; i.e. the long-term average annual rainfall depth divided by the average number of rainy days; r2 = 0.47). Other factors (e.g. land use or soil type) showed no significant correlation with the observed GHR rates. This may be attributed to the uncertainties associated with accurately quantifying these factors. In addition, available time series data demonstrate that GHR rates are subject to very large year-to-year variations. As a result, average GHR rates measured over short (100%) uncertainties. We integrated our findings into a weighted regression model that simulates the volumetric retreat rate of a gully headcut as a function of upstream drainage area and RDN. When weighing each GHR observation proportional to its measuring period, this model explains 68% of the observed variance in GHR rates at a global scale. For 76% of the monitored gullies, the simulated GHR values deviate less than one order of magnitude from their corresponding observed value. Our model clearly indicates that GHR rates are very sensitive to rainfall intensity. Since these intensities are expected to increase in most areas as a result of climate change, our results suggest that gully erosion worldwide will become more intense and widespread in the following decades. Finally, we discuss research topics that will help to address these challenges

Is adenomyosis the neglected phenotype of an endomyometrial dysfunction syndrome?

Since the dissociation between adenomyoma and endometriosis in the 1920s and the laparoscopic progress in the diagnosis and surgery of endometriosis, the literature has been greatly focused on the disease endometriosis. The study of adenomyosis, on the other hand, has been neglected as the diagnosis remained based on hysterectomy specimens. However, since the introduction of magnetic resonance and sonographic imaging techniques in the 1980s, the myometrial junctional zone has been identified as a third uterine zone and interest in adenomyosis was renewed. This has also been the start for the interest in the role of the myometrial junctional zone dysfunction and adenomyosis in reproductive and obstetrical disorders

Researching underwater: a submerged study

This chapter explores the unknown territory of a lost project: an ethnography of a public swimming pool. The discussion is contextualised within my broader sociological theory of ‘nothing’, as a category of unmarked, negative social phenomena, including no-things, no-bodies, no-wheres, non-events and non-identities. These meaningful symbolic objects are constituted through social interaction, which can take two forms: acts of commission and acts of omission. I tell the story of how this project did not happen, through the things I did not do or that did not materialise, and how I consequently did not become a certain type of researcher. I identify three types of negative phenomena that I did not observe and document – invisible figures, silent voices and empty vessels – and, consequently, the knowledge I did not acquire. However, nothing is also productive, generating new symbolic objects as substitutes, alternatives and replacements: the somethings, somebodies and somewheres that are done or made instead. Thus finally, I reflect on how not doing this project led me to pursue others, cultivating a different research identity that would not otherwise have existed

Back to the past: the individual and its role in creativity in organisations

O objetivo deste texto é realçar o papel do indivíduo na criatividade nas organizações. Esse papel tem sido estranhamente remetido para um plano secundário, à medida que as modernas visões da criatividade a definem, sobretudo, com relação ao contexto em que ocorre. De fato, na perspectiva atual, a criatividade não pode ser entendida sem se considerarem os contextos funcional, relacional e organizacional nos quais está inserido o trabalhador. Tais são as considerações da maior parte dos autores que escreve sobre o tópico, como sejam Amabile (1996), Csikszentmihalyi (1996), ou, mais recentemente, Glăveanu (2010a, 2010b). Essa corrente dominante, com origem no interacionismo psico-social, tem ainda influenciado o desenvolvimento teórico de outros conceitos em psicologia, sociologia, e, na sequência, nas ciências sociais e humanas, e na gestão. Essa supremacia no que concerne a criatividade, tem conduzido os autores a olvidar o papel do indivíduo no processo e no resultado criativos, chegando a retirar-lhe a responsabilidade e o protagonismo pela geração e produção de ideias. Desse modo, no presente texto, recuperam-se os argumentos em favor da centralidade da pessoa na criatividade, defendendo-se que esta tem uma existência isolada de influências externas, e que, como tal, devem relembrar-se as bases individuais da criatividadeThe goal of the current text is to highlight the role of the individual in creativity in organisations. This role has been strangely disregarded in recent years, as modern accounts of creativity have been emphasising the idea that creativity is only defined in context. This main stream argues that creativity is a process that essentially occurs within a functional, relational, and organisational context in which workers are inserted. Key authors defending such a position include the likes of Amabile (1996), Csikszentmihalyi (1996), and, more recently, Glăveanu (2010a, 2010b). This is a vision rooted in the psychosocial interactionist perspective, which has also had a considerable impact in other areas in psychology, sociology, management and other social and human sciences. This supremacy, with regards to creativity, has led many to forget the role of the individual person in the creative process and output, removing their responsibility and protagonism for generating and producing ideas. Hence, the current text intends to bring back to discussion the individual bases of creativity, that people can have an existence isolated from external influences, further defending that the concept can and should be defined out of context, rather than in contextinfo:eu-repo/semantics/publishedVersio