8,250 research outputs found
A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis.
Background: Tuberculosis (TB) remains an urgent global public health priority, causing 1.5 million deaths worldwide in 2018. There is evidence that psychosocial factors modulate immune function; however, how this may influence TB risk or BCG vaccine response, and whether this pathway can be modified through social protection, has not been investigated. This paper aims to: a) systematically review evidence of how psychosocial factors influence the expression of biomarkers of immunity, and b) apply this general evidence to propose plausible TB-specific pathways for future study. Methods: Papers reporting on the impact of psychosocial stressors on immune biomarkers in relation to infectious disease risk were identified through a search of the databases MEDLINE, PsycINFO, Global Health and PsycEXTRA alongside reference list and citation searching of key papers. Data extraction and critical appraisal were carried out using a standardised form. The findings were tabulated and synthesised narratively by infectious disease category, and used to propose plausible mechanisms for how psychosocial exposures might influence immune outcomes relevant to TB and BCG response. Results: 27,026 citations were identified, of which 51 met the inclusion criteria. The literature provides evidence of a relationship between psychosocial factors and immune biomarkers. While the direction and strength of associations is heterogenous, some overarching patterns emerged: adverse psychosocial factors (e.g. stress) were generally associated with compromised vaccine response and higher antibody titres to herpesviruses, and vice versa for positive psychosocial factors (e.g. social support). Conclusions: The evidence identifies pathways linking psychosocial factors and immune response: co-viral infection and immune suppression, both of which are potentially relevant to TB and BCG response. However, the heterogeneity in the strength and nature of the impact of psychosocial factors on immune function, and lack of research on the implications of this relationship for TB, underscore the need for TB-specific research
Late Miocene to early Pliocene stratigraphic record in northern Taranaki Basin: Condensed sedimentation ahead of Northern Graben extension and progradation of the modern continental margin
The middle Pliocene-Pleistocene progradation of the Giant Foresets Formation in Taranaki Basin built up the modern continental margin offshore from western North Island. The late Miocene to early Pliocene interval preceding this progradation was characterised in northern Taranaki Basin by the accumulation of hemipelagic mudstone (Manganui Formation), volcaniclastic sediments (Mohakatino Formation), and marl (Ariki Formation), all at bathyal depths. The Manganui Formation has generally featureless wireline log signatures and moderate to low amplitude seismic reflection characteristics. Mohakatino Formation is characterised by a sharp decrease in the GR log value at its base, a blocky GR log motif reflecting sandstone packets, and erratic resistivity logs. Seismic profiles show bold laterally continuous reflectors. The Ariki Formation has a distinctive barrel-shaped to blocky GR log motif. This signature is mirrored by the SP log and often by an increase in resistivity values through this interval. The Ariki Formation comprises (calcareous) marl made up of abundant planktic foraminifera, is 109 m thick in Ariki-1, and accumulated over parts of the Western Stable Platform and beneath the fill of the Northern Graben. It indicates condensed sedimentation reflecting the distance of the northern region from the contemporary continental margin to the south
Feedback first: the surprisingly weak effects of magnetic fields, viscosity, conduction, and metal diffusion on galaxy formation
Using high-resolution simulations with explicit treatment of stellar feedback
physics based on the FIRE (Feedback in Realistic Environments) project, we
study how galaxy formation and the interstellar medium (ISM) are affected by
magnetic fields, anisotropic Spitzer-Braginskii conduction and viscosity, and
sub-grid metal diffusion from unresolved turbulence. We consider controlled
simulations of isolated (non-cosmological) galaxies but also a limited set of
cosmological "zoom-in" simulations. Although simulations have shown significant
effects from these physics with weak or absent stellar feedback, the effects
are much weaker than those of stellar feedback when the latter is modeled
explicitly. The additional physics have no systematic effect on galactic star
formation rates (SFRs) . In contrast, removing stellar feedback leads to SFRs
being over-predicted by factors of . Without feedback, neither
galactic winds nor volume filling hot-phase gas exist, and discs tend to
runaway collapse to ultra-thin scale-heights with unphysically dense clumps
congregating at the galactic center. With stellar feedback, a multi-phase,
turbulent medium with galactic fountains and winds is established. At currently
achievable resolutions and for the investigated halo mass range
, the additional physics investigated here (MHD,
conduction, viscosity, metal diffusion) have only weak (-level)
effects on regulating SFR and altering the balance of phases, outflows, or the
energy in ISM turbulence, consistent with simple equipartition arguments. We
conclude that galactic star formation and the ISM are primarily governed by a
combination of turbulence, gravitational instabilities, and feedback. We add
the caveat that AGN feedback is not included in the present work
A possible phase diagram of a t-J ladder model
We investigate a t-J ladder model by numerical diagonalization method. By
calculating correlation functions and assuming the Luttinger liquid relation,
we obtained a possible phase diagram of the ground state as a function of J/t
and electron density . We also found that behavior of correlation functions
seems to consist with the prediction of Luttinger liquid relation. The result
suggests that the superconducting phase appear in the region of for high electron density and for low electron density.Comment: Latex, 10 pages, figures available upon reques
Classical and quantum spinor cosmology with signature change
We study the classical and quantum cosmology of a universe in which the
matter source is a massive Dirac spinor field and consider cases where such
fields are either free or self-interacting. We focus attention on the spatially
flat Robertson-Walker cosmology and classify the solutions of the
Einstein-Dirac system in the case of zero, negative and positive cosmological
constant . For , these solutions exhibit signature
transitions from a Euclidean to a Lorentzian domain. In the case of massless
spinor fields it is found that signature changing solutions do not exist when
the field is free while in the case of a self-interacting spinor field such
solutions may exist. The resulting quantum cosmology and the corresponding
Wheeler-DeWitt equation are also studied for both free and self interacting
spinor fields and closed form expressions for the wavefunction of the universe
are presented. These solutions suggest a quantization rule for the energy.Comment: 13 pages, 4 figure
The failure of stellar feedback, magnetic fields, conduction, and morphological quenching in maintaining red galaxies
The quenching "maintenance'" and related "cooling flow" problems are
important in galaxies from Milky Way mass through clusters. We investigate this
in halos with masses , using
non-cosmological high-resolution hydrodynamic simulations with the FIRE-2
(Feedback In Realistic Environments) stellar feedback model. We specifically
focus on physics present without AGN, and show that various proposed "non-AGN"
solution mechanisms in the literature, including Type Ia supernovae, shocked
AGB winds, other forms of stellar feedback (e.g. cosmic rays), magnetic fields,
Spitzer-Braginskii conduction, or "morphological quenching" do not halt or
substantially reduce cooling flows nor maintain "quenched" galaxies in this
mass range. We show that stellar feedback (including cosmic rays from SNe)
alters the balance of cold/warm gas and the rate at which the cooled gas within
the galaxy turns into stars, but not the net baryonic inflow. If anything,
outflowing metals and dense gas promote additional cooling. Conduction is
important only in the most massive halos, as expected, but even at reduces inflow only by a factor (owing to
saturation effects and anisotropic suppression). Changing the morphology of the
galaxies only slightly alters their Toomre- parameter, and has no effect on
cooling (as expected), so has essentially no effect on cooling flows or
maintaining quenching. This all supports the idea that additional physics,
e.g., AGN feedback, must be important in massive galaxies.Comment: 16 pages, 12 figure
Enhancement of Pairing Correlation and Spin Gap through Suppression of Single-Particle Dispersion in One-Dimensional Models
We investigate the effects of suppression of single-particle dispersion near
the Fermi level on the spin gap and the singlet-pairing correlation by using
the exact diagonalization method for finite-size systems. We consider strongly
correlated one-dimensional models, which have flat band dispersions near wave
number k=\pi/2, if the interactions are switched off. Our results for strongly
correlated models show that the spin gap region expands as the single-particle
dispersion becomes flatter. The region where the singlet-pairing correlation is
the most dominant also expands in models with flatter band dispersions. Based
on our numerical results, we propose a pairing mechanism induced by the
flat-band dispersion.Comment: 5 pages, including 5 eps figures, to appear in J.Phys.Soc.Jpn Vol.69
No.
Multi-black holes and instantons in effective string theory
The effective action for string theory which takes into account non-minimal
coupling of moduli admits multi-black hole solutions. The euclidean
continuation of these solutions can be interpreted as an instanton mediating
the splitting and recombination of the throat of extremal magnetically charged
black holes.Comment: 10 pages, plain Te
SIDM on FIRE: Hydrodynamical Self-Interacting Dark Matter simulations of low-mass dwarf galaxies
We compare a suite of four simulated dwarf galaxies formed in 10 haloes of collisionless Cold Dark Matter (CDM) with galaxies
simulated in the same haloes with an identical galaxy formation model but a
non-zero cross-section for dark matter self-interactions. These cosmological
zoom-in simulations are part of the Feedback In Realistic Environments (FIRE)
project and utilize the FIRE-2 model for hydrodynamics and galaxy formation
physics. We find the stellar masses of the galaxies formed in Self-Interacting
Dark Matter (SIDM) with are very similar to those in CDM
(spanning ) and all runs lie on a
similar stellar mass -- size relation. The logarithmic dark matter density
slope () in the central pc remains
steeper than for the CDM-Hydro simulations with stellar mass
and core-like in the most massive galaxy.
In contrast, every SIDM hydrodynamic simulation yields a flatter profile, with
. Moreover, the central density profiles predicted in SIDM runs
without baryons are similar to the SIDM runs that include FIRE-2 baryonic
physics. Thus, SIDM appears to be much more robust to the inclusion of
(potentially uncertain) baryonic physics than CDM on this mass scale,
suggesting SIDM will be easier to falsify than CDM using low-mass galaxies. Our
FIRE simulations predict that galaxies less massive than provide potentially ideal targets for discriminating models,
with SIDM producing substantial cores in such tiny galaxies and CDM producing
cusps.Comment: 10 Pages, 7 figures, submitted to MNRA
Cosmological perturbations and classical change of signature
Cosmological perturbations on a manifold admitting signature change are
studied. The background solution consists in a Friedmann-Lemaitre-Robertson-
Walker (FLRW) Universe filled by a constant scalar field playing the role of a
cosmological constant. It is shown that no regular solution exist satisfying
the junction conditions at the surface of change. The comparison with similar
studies in quantum cosmology is made.Comment: 35 pages, latex, 2 figures available at [email protected], to
appear in Physical Review
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