Molecular complexity determines the number of olfactory notes and the pleasantness of smells

One major unresolved problem in olfaction research is to relate the percept to the molecular structure of stimuli. The present study examined this issue and showed for the first time a quantitative structure-odor relationship in which the more structurally complex a monomolecular odorant, the more numerous the olfactory notes it evokes. Low-complexity odorants were also rated as more aversive, reflecting the fact that low molecular complexity may serve as a warning cue for the olfactory system. Taken together, these findings suggest that molecular complexity provides a framework to explain the subjective experience of smells

Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep

Impaired sleep and enhanced stress hormone secretion are the hallmarks of stress-related disorders, including major depression. The central neuropeptide, corticotropin-releasing hormone (CRH), is a key hormone that regulates humoral and behavioral adaptation to stress. Its prolonged hypersecretion is believed to play a key role in the development and course of depressive symptoms, and is associated with sleep impairment. To investigate the specific effects of central CRH overexpression on sleep, we used conditional mouse mutants that overexpress CRH in the entire central nervous system (CRH-COE-Nes) or only in the forebrain, including limbic structures (CRH-COE-Cam). Compared with wild-type or control mice during baseline, both homozygous CRH-COE-Nes and -Cam mice showed constantly increased rapid eye movement (REM) sleep, whereas slightly suppressed non-REM sleep was detected only in CRH-COE-Nes mice during the light period. In response to 6-h sleep deprivation, elevated levels of REM sleep also became evident in heterozygous CRH-COE-Nes and -Cam mice during recovery, which was reversed by treatment with a CRH receptor type 1 (CRHR1) antagonist in heterozygous and homozygous CRH-COE-Nes mice. The peripheral stress hormone levels were not elevated at baseline, and even after sleep deprivation they were indistinguishable across genotypes. As the stress axis was not altered, sleep changes, in particular enhanced REM sleep, occurring in these models are most likely induced by the forebrain CRH through the activation of CRHR1. CRH hypersecretion in the forebrain seems to drive REM sleep, supporting the notion that enhanced REM sleep may serve as biomarker for clinical conditions associated with enhanced CRH secretion

Enhanced quality using intensive test and analysis on simulators

Conference of 18th Euromicro Conference on Digital System Design, DSD 2015 ; Conference Date: 26 August 2015 Through 28 August 2015; Conference Code:117072International audienceEmbedded systems are becoming ubiquitous and are subject to demanding standards in both safety and reliability. Modern vehicles, which must respect ISO 26262 standards, use up to 100 Electronic Control Unit (ECUs). Advances in microelectronics enable integration of more functions in the ECU, but at the cost of greater unreliability in hostile operating environments, such as electromagnetic fields, temperature, and humidity. Their software mainly drives embedded system flexibility and smartness. However due to lack of automation, its validation and verification (V&V) takes place throughout the design process and tends to swallow up 40% to 50% of the total development cost. The 'Enhanced Quality Using Intensive Test Analysis on Simulators' (EQUITAS) project intends to limit the impact of software V&V on embedded systems cost and time-To-market while improving reliability and functional safety. Project activities include: development of a continuous tool-chain to automate the V&V process of embedded computers, improving the relevance of the test campaigns by detecting the redundant tests using equivalence classes, providing assistance for hardware failure effect analysis (FMEA), and finally assessing the tool-chain under the ISO 26262 requirements