Sistema de Balanço Hídrico: manual do desenvolvedor.

O Sistema Balanço Hídrico, elaborado pela Unidade, completa o Sistema AgroCast desenvolvido e divulgado pela Agência Estado. O AgroCast disponibiliza diversas informações para o AgroNegócio, como commodities, previsão de tempo, taxas etc. Já o sistema desenvolvido pela Unidade, disponibiliza na internet dados sobre o Balanço Hídrico para diversos estados de São Paulo, com a possibilidade de gerar dados especificamente para os tipos de solos existente na região.bitstream/item/116952/1/898.PD

Manual do Sistema Balanço Hídrico e Calendário Agrícola.

Manual do Sistema Balanço Hídrico; Explicação e observações sobre os termos empregados nas tabelas do Balanço Hídrico; Modelo Entidade Relacionamento (MER); Objetivo operacional do sistema; Diferenciamento das duas maneiras de processamento do sistema; Funcionamento; Módulo arquivos; Módulo Balanço Hídrico; Módulo Utilitário; Módulo Sobre.bitstream/item/116808/1/834.pd

Interplay between the endogenous opioid system and proteasome complex: Beyond signaling

Intracellular signaling mechanisms underlying the opioid system regulation of nociception, neurotransmitters release, stress responses, depression, and the modulation of reward circuitry have been investigated from different points of view. The presence of the ubiquitin proteasome system (UPS) in the synaptic terminations suggest a potential role of ubiquitin-dependent mechanisms in the control of the membrane occupancy by G protein-coupled receptors (GPCRs), including those belonging to the opioid family. In this review, we focused our attention on the role played by the ubiquitination processes and by UPS in the modulation of opioid receptor signaling and in pathological conditions involving the endogenous opioid system. The collective evidence here reported highlights the potential usefulness of proteasome inhibitors in neuropathic pain, addictive behavior, and analgesia since these molecules can reduce pain behavioral signs, heroin self-administration, and the development of morphine analgesic tolerance. Moreover, the complex mechanisms involved in the effects induced by opioid agonists binding to their receptors include the ubiquitination process as a post-translational modification which plays a relevant role in receptor trafficking and degradation. Hence, UPS modulation may offer novel opportunities to control the balance between therapeutic versus adverse effects evoked by opioid receptor activation, thus, representing a promising druggable target

Mindfulness and emotional regulation as sequential mediators in the relationship between attachment security and depression

Depression is a significant global health issue that has previously been associated with negative early care experiences and insecure attachment styles. This has led to much interest in identifying variables that may interrupt this relationship and prevent detrimental personal, social and economic outcomes. Recent research has indicated associations between the two seemingly distinct constructs of secure attachment and mindfulness, with similar positive outcomes. One hundred and forty eight participants completed an online survey exploring a possible sequential cognitive processing model, which predicted that higher levels of mindfulness and then emotional regulation would mediate the relationship between attachment and depression. Full mediation was found in regards to secure, preoccupied and dismissive attachment, whereas partial mediation was identified in the case of fearful attachment. The results support the possibility of an alternative cognitive processing pathway that may interrupt the association between negative early care experiences and concomitant negative mental health outcomes. Further exploration of this relationship is indicated

Short-term withdrawal from repeated exposure to cocaine during adolescence modulates dynorphin mRNA levels and BDNF signaling in the rat nucleus accumbens

BACKGROUND: Early-life stressful events affect the neurobiological maturation of cerebral circuitries including the endogenous opioid system and the effects elicited by adolescent cocaine exposure on this system have been poorly investigated. Here, we evaluated whether cocaine exposure during adolescence causes short- or long-term alterations in mRNAs codifying for selected elements belonging to the opioid system. Moreover, since brain-derived neurotrophic factor (BDNF) may undergo simultaneous alterations with the opioid peptide dynorphin, we also evaluated its signaling pathway as well. METHODS: Adolescent male rats were exposed to cocaine (20\u2009mg/kg/day) from post-natal day (PND) 28 to PND42, approximately corresponding to human adolescence. After short- (PND45) or long-term (PND90) abstinence, prodynorphin-\u3ba-opioid receptor (pDYN-KOP) and pronociceptin-nociceptin receptor (pN/OFQ-NOP) gene expression were evaluated in the nucleus accumbens (NAc) and hippocampus (Hip) together with the analysis of BDNF signaling pathways. RESULTS: In the NAc of PND45 rats, pDYN mRNA levels were up-regulated, an effect paralled by increased BDNF signaling. Differently from NAc, pDYN mRNA levels were down-regulated in the Hip of PND45 rats without significant changes of BDNF pathway. At variance from PND45 rats, we did not find any significant alteration of the investigated parameters either in NAc and Hip of PND90 rats. CONCLUSIONS: Our results indicate that the short-term withdrawal from adolescent cocaine exposure is characterized by a parallel pDYN mRNA and BDNF signaling increase in the NAc. Given the depressive-like state experienced during short abstinence in humans, we hypothesize that such changes may contribute to promote the risk of cocaine abuse escalation and relapse

Discovery of a faint, star-forming, multiply lensed, Lyman-alpha blob

We report the discovery of a multiply lensed Lyman-$\alpha$ blob (LAB) behind the galaxy cluster AS1063 using the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT). The background source is at $z=$ 3.117 and is intrinsically faint compared to almost all previously reported LABs. We used our highly precise strong lensing model to reconstruct the source properties, and we find an intrinsic luminosity of $L_{\rm Ly\alpha}$=$1.9\times10^{42}$ erg s$^{-1}$, extending to 33 kpc. We find that the LAB is associated with a group of galaxies, and possibly a protocluster, in agreement with previous studies that find LABs in overdensities. In addition to Lyman-$\alpha$ (Ly$\alpha$) emission, we find \ion{C}{IV}, \ion{He}{II}, and \ion{O}{III}] ultraviolet (UV) emission lines arising from the centre of the nebula. We used the compactness of these lines in combination with the line ratios to conclude that the \Lya nebula is likely powered by embedded star formation. Resonant scattering of the \Lya photons then produces the extended shape of the emission. Thanks to the combined power of MUSE and strong gravitational lensing, we are now able to probe the circumgalatic medium of sub-$L_{*}$ galaxies at $z\approx 3$.Comment: 7 pages, 7 figures; moderate changes to match the accepted A&A versoi

Deficiência hídrica acumulada como índice de risco de incêndios florestais.

O trabalho analisa riscos de incêndios florestais em locais onde se dispõe apenas de dados de temperatura e chuva; apresenta os balanços hídricos climatológicos dos anos de 1999 e 2000, que caracterizam os períodos de maiores riscos de ocorrência de incêndios, comparando-os ainda ao balanço hídrico normal para Piracicaba-SP

Species-Specific Diversity of a Fixed Motor Pattern: The Electric Organ Discharge of Gymnotus

Understanding fixed motor pattern diversity across related species provides a window for exploring the evolution of their underlying neural mechanisms. The electric organ discharges of weakly electric fishes offer several advantages as paradigmatic models for investigating how a neural decision is transformed into a spatiotemporal pattern of action. Here, we compared the far fields, the near fields and the electromotive force patterns generated by three species of the pulse generating New World gymnotiform genus Gymnotus. We found a common pattern in electromotive force, with the far field and near field diversity determined by variations in amplitude, duration, and the degree of synchronization of the different components of the electric organ discharges. While the rostral regions of the three species generate similar profiles of electromotive force and local fields, most of the species-specific differences are generated in the main body and tail regions of the fish. This causes that the waveform of the field is highly site dependant in all the studied species. These findings support a hypothesis of the relative separation of the electrolocation and communication carriers. The presence of early head negative waves in the rostral region, a species-dependent early positive wave at the caudal region, and the different relationship between the late negative peak and the main positive peak suggest three points of lability in the evolution of the electrogenic system: a) the variously timed neuronal inputs to different groups of electrocytes; b) the appearance of both rostrally and caudally innervated electrocytes, and c) changes in the responsiveness of the electrocyte membrane