Neutral Hydrogen Mapping of Virgo Cluster Blue Compact Dwarf Galaxies

A new installment of neutral hydrogen mappings of Blue Compact Dwarf galaxies, as defined by optical morphology, in and near the Virgo cluster is presented. The primary motivation was to search for outlying clouds of HI as potential interactive triggers of the enhanced star formation, and therefore the mapped galaxies were selected for large HI} mass, large optical diameter, and large velocity profile width. Approximately half the sample proved to have one or more small, low column density star-free companion clouds, either detached or appearing as an appendage in our maps, at resolution of order 4 kpc. Comparison is made to a sample of similarly mapped field BCD galaxies drawn from the literature; however, the Virgo cluster sample of mapped BCDs is still too small for conclusive comparisons to be made. We found, on the one hand, little or no evidence for ram pressure stripping nor, on the other, for extremely extended low column density HI envelopes. The HI rotation curves in most cases rise approximately linearly, and slowly, as far out as we can trace the gas.Comment: To appear in AJ, Dec. 200

Spectral Graph Convolutions for Population-based Disease Prediction

Exploiting the wealth of imaging and non-imaging information for disease prediction tasks requires models capable of representing, at the same time, individual features as well as data associations between subjects from potentially large populations. Graphs provide a natural framework for such tasks, yet previous graph-based approaches focus on pairwise similarities without modelling the subjects' individual characteristics and features. On the other hand, relying solely on subject-specific imaging feature vectors fails to model the interaction and similarity between subjects, which can reduce performance. In this paper, we introduce the novel concept of Graph Convolutional Networks (GCN) for brain analysis in populations, combining imaging and non-imaging data. We represent populations as a sparse graph where its vertices are associated with image-based feature vectors and the edges encode phenotypic information. This structure was used to train a GCN model on partially labelled graphs, aiming to infer the classes of unlabelled nodes from the node features and pairwise associations between subjects. We demonstrate the potential of the method on the challenging ADNI and ABIDE databases, as a proof of concept of the benefit from integrating contextual information in classification tasks. This has a clear impact on the quality of the predictions, leading to 69.5% accuracy for ABIDE (outperforming the current state of the art of 66.8%) and 77% for ADNI for prediction of MCI conversion, significantly outperforming standard linear classifiers where only individual features are considered.Comment: International Conference on Medical Image Computing and Computer-Assisted Interventions (MICCAI) 201

The Reddening-Free Decline Rate Versus Luminosity Relationship for Type Ia Supernovae

We develop a method for estimating the host galaxy dust extinction for type Ia supernovae based on an observational coincidence first noted by Lira (1995), who found that the B-V evolution during the period from 30-90 days after V maximum is remarkably similar for all events, regardless of light curve shape. This fact is used to calibrate the dependence of the B(max)-V(max) and V(max)-I(max) colors on the light curve decline rate parameter delta-m15, which can, in turn, be used to separately estimate the host galaxy extinction. Using these methods to eliminate the effects of reddening, we reexamine the functional form of the decline rate versus luminosity relationship and provide an updated estimate of the Hubble constant of Ho = 63.3 +- 2.2(internal) +- 3.5(external) km/s/Mpc.Comment: 32 pages, 10 figures, AJ 1999 in pres

The Hamburg/SAO Survey for Emission-Line Galaxies. III. The Third List of 81 Galaxies

We present the third list with results {Tables 2 to 6 are available only in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html. Figures A1 to A9 will be made available only in the electronic version of the journal.} of the Hamburg/SAO Survey for Emission-Line Galaxies (HSS therein, SAO - Special Astrophysical Observatory, Russia). This survey is based on the digitized objective-prism photoplate database of the Hamburg Quasar Survey (HQS). Here, we present new spectroscopic results of candidates which were obtained in 1998 with the 2.1 m KPNO and the 2.2 m Calar Alto telescopes. All candidates are selected in the declination band +35$^{\circ}$ to +40$^{\circ}$. The follow-up spectroscopy with the 2 m class telescopes confirmed 85 emission-line objects out of 113 observed candidates and allowed their quantitative spectral classification. For 80 of them, the redshifts are determined for the first time. For 5 previously known ELGs, line ratios are presented for the first time. We could classify 55 out of the 85 emission-line objects as BCG/H{\sc ii} galaxies or probable BCGs, 4 - as QSOs, 6 - as Seyfert galaxies, 1 - as super-association in a subluminous spiral galaxy, and 11 are low-excitation objects - either starburst nuclear (SBN), or dwarf amorphous nuclear starburst galaxies (DANS). We could not classify 8 ELGs. Further, for 8 more galaxies we did not detect any significant emission lines.Comment: A&A latex file with 8 tables and one figure. Astron. Astrophys. Suppl. accepted 200

The extinction law in high redshift galaxies

We estimate the dust extinction laws in two intermediate redshift galaxies. The dust in the lens galaxy of LBQS1009-0252, which has an estimated lens redshift of zl~0.88, appears to be similar to that of the SMC with no significant feature at 2175 A. Only if the lens galaxy is at a redshift of zl~0.3, completely inconsistent with the galaxy colors, luminosity or location on the fundamental plane, can the data be fit with a normal Galactic extinction curve. The dust in the zl=0.68 lens galaxy for B0218+357, whose reddened image lies behind a molecular cloud, requires a very flat ultraviolet extinction curve with (formally) R(V)=12 +- 2. Both lens systems seem to have unusual extinction curves by Galactic standards.Comment: 15 pages, 3 figures. ApJ in pres

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are largely unknown. Detecting core components of Wnt and Hh signaling and mathematical modeling showed that both pathways in healthy liver act largely complementary to each other in the pericentral (Wnt) and the periportal zone (Hh) and communicate mainly by mutual repression. The Wnt/Hh module inversely controls the spatiotemporal operation of various liver metabolic pathways, as revealed by transcriptome, proteome, and metabolome analyses. Shifting the balance to Wnt (activation) or Hh (inhibition) causes pericentralization and periportalization of liver functions, respectively. Thus, homeostasis of the Wnt/Hh module is essential for maintaining proper liver metabolism and to avoid the development of certain metabolic diseases. With caution due to minor species-specific differences, these conclusions may hold for human liver as well

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and cause disease, long-term epidemiological data indicate that humans represent a spill-over host in which infection with M. bovis is not self-maintaining. Indeed, human-to-human transmission of M. bovis strains and other members of the animal lineage of the tubercle bacilli is very rare. Here, we report on three mutations affecting the two-component virulence regulation system PhoP/PhoR (PhoPR) in M. bovis and in the closely linked Mycobacterium africanum lineage 6 (L6) that likely account for this discrepancy. Genetic transfer of these mutations into the human TB agent, Mycobacterium tuberculosis, resulted in down-regulation of the PhoP regulon, with loss of biologically active lipids, reduced secretion of the 6-kDa early antigenic target (ESAT-6), and lower virulence. Remarkably, the deleterious effects of the phoPR mutations were partly compensated by a deletion, specific to the animal-adapted and M. africanum L6 lineages, that restores ESAT-6 secretion by a PhoPR-independent mechanism. Similarly, we also observed that insertion of an IS6110 element upstream of the phoPR locus may completely revert the phoPR-bovis–associated fitness loss, which is the case for an exceptional M. bovis human outbreak strain from Spain. Our findings ultimately explain the long-term epidemiological data, suggesting that M. bovis and related phoPR-mutated strains pose a lower risk for progression to overt human TB, with major impact on the evolutionary history of TB

Image-based dosimetry for 225Ac-PSMA-I&T therapy using quantitative SPECT

Purpose!#!After a decade of PET/MR, the case of attenuation correction (AC) remains open. The initial four-compartment (air, water, fat, soft tissue) Dixon-based AC scheme has since been expanded with several features, the latest being MR field-of-view extension and a bone atlas. As this potentially changes quantification, we evaluated the impact of these features in PET AC in prostate cancer patients.!##!Methods!#!Two hundred prostate cancer patients were examined with either !##!Results!#!High correlation and no visually perceivable differences between all evaluated methods (r > 0.996) were found. The mean relative difference in lesion uptake of !##!Conclusions!#!Based on these results and the encountered bone atlas registration inaccuracy, we deduce that including bones and extending the MR field-of-view did not introduce clinically significant differences in PSMA diagnostic accuracy and tracer uptake quantification in prostate cancer pelvic lesions, facilitating the analysis of serial studies respectively. However, in the absence of ground truth data, we advise against atlas-based methods when comparing serial scans for bone lesions

The starburst phenomenon from the optical/near-IR perspective

The optical/near-IR stellar continuum carries unique information about the stellar population in a galaxy, its mass function and star-formation history. Star-forming regions display rich emission-line spectra from which we can derive the dust and gas distribution, map velocity fields, metallicities and young massive stars and locate shocks and stellar winds. All this information is very useful in the dissection of the starburst phenomenon. We discuss a few of the advantages and limitations of observations in the optical/near-IR region and focus on some results. Special attention is given to the role of interactions and mergers and observations of the relatively dust-free starburst dwarfs. In the future we expect new and refined diagnostic tools to provide us with more detailed information about the IMF, strength and duration of the burst and its triggering mechanisms.Comment: 6 pages, 3 figures, to appear in "Starbursts: from 30 Doradus to Lyman Break Galaxies" 2005, eds. R. de Grijs and R. M. Gonzalez Delgado (Kluwer