SARS-CoV-2 infection in aplastic anaemia

Not available

Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus -- the "D-shuttle" project --

Twelve high schools in Japan (of which six are in Fukushima Prefecture), four in France, eight in Poland and two in Belarus cooperated in the measurement and comparison of individual external doses in 2014. In total 216 high-school students and teachers participated in the study. Each participant wore an electronic personal dosimeter "D-shuttle" for two weeks, and kept a journal of his/her whereabouts and activities. The distributions of annual external doses estimated for each region overlap with each other, demonstrating that the personal external individual doses in locations where residence is currently allowed in Fukushima Prefecture and in Belarus are well within the range of estimated annual doses due to the background radiation level of other regions/countries

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (<380 AU ml−1). Vaccine failure rates were highest in ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis on immunosuppressive therapy (6/30, 20%) and solid organ transplant recipients (20/81, 25% and 141/458, 31%). SARS-CoV-2-specific T cell responses were detected in 513 of 580 (88%) patients, with lower T cell magnitude or proportion in hemodialysis, allogeneic hematopoietic stem cell transplantation and liver transplant recipients (versus healthy controls). Humoral responses against Omicron (BA.1) were reduced, although cross-reactive T cell responses were sustained in all participants for whom these data were available. BNT162b2 was associated with higher antibody but lower cellular responses compared to ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 infection episodes, including 48 individuals with hospitalization or death from COVID-19. Decreased magnitude of both the serological and the T cell response was associated with severe COVID-19. Overall, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies

Occurrence of malignancy in endometrial polyps during postmenopause

Objective.: To evaluate the occurrence of endometrial polyp malignancy in pre- and postmenopausal women with or without symptoms. Materials and Methods: A retrospective study was performed on 351 patients with endometrial polyps diagnosed by hysteroscopy. Results: Histological findings of biopsies obtained by operative hysteroscopy confirmed the presence of a simple endometrial polyp in 179 cases, polyps with typical simple hyperplasia in 42 cases, polyps with typical complex hyperplasia in 24 cases. polyps with atypical complex hyperplasia in three cases; carcinomatous polyps in seven cases; atrophic polyps in 17 cases; functional polyps in 56 cases; and inadequate sample in 23 cases. All seven patients with adenocarcinoma were symptomatic; six out of seven patients with adenocarcinoma were in postmenopause and one was in premenopause. The association between menopausal status and symptoms, and the presence of a malignant lesion was statistically significant (p < 0.001). Conclusions: This: study revealed that prevalence of endometrial polyp malignant transformation was <= 2.84% in postmenopausal and symptomatic patients

Diagnosi di rogna sarcoptica nei suini al macello

Sarcoptes scabiei var. suis è l'agente eziologico della rogna sarcoptica dei suini, una delle più importanti cause di perdite economiche nell'allevamento del maiale . La stima della prevalenza di questa parassitosi è spesso difficile per problemi diagnostici. In questo lavoro sono state comparate 4 tecniche (esame microscopico dei raschiati cutanei, Average Dermatitis Score, test ELISA su siero ed estratto di muscolo) per valutare le potenzialità di utilizzo di un monitoraggio alla macellazione ai fini di interpretare lo stato parassitologico degli allevamenti. I campionamenti sono stati effettuati da 380 suini di 9-10 mesi di età presso un macello di Carpi (MO). La correlazione dei risultati delle 4 procedure diagnostiche utilizzate è stata valutata mediante il calcolo del coefficiente di correlazione non parametrico di Spearman. Non è stata evidenziata una correlazione significativa tra lesioni cutanee (ADS) e la presenza di S. scabiei all'esame microscopico e tra quest'ultimo e i test ELISA. Una correlazione al limite della significatività statistica (p=0,055) è stata invece osservata tra ADS e ELISA su siero. I risultati del test ELISA su siero e del test ELISA su MJ sono invece correlati (p&lt;0,05)

INNOLABS. Valorizzazione dei sistemi territoriali interni della Val Fontanabuona \u2013 Genova. L\u2019anello del Monte Caucaso

Il progetto INTERREG INNOLABS interessa l'intera area transfrontaliera marittima italo-francese (Alpi Marittime, Liguria, Toscana, Corsica, Sardegna) promuovendo lo sviluppo di progetti di governance territoriale per le aree interne insieme a decisori politici locali, attori economici, enti territoriali e altri componenti dei programmi Leader. L'obiettivo \ue8 riconnettere i valori territoriali esistenti (paesaggi culturali, ambientali) e le risorse materiali con il contesto sociale ed economico del territorio, misurando lo sviluppo di una potenziale strategia di riqualificazione turistica sostenibile. Il progetto pilota \u201cAnello del Monte Caucaso\u201d definisce strategie di sviluppo di una rete di servizi per il cicloturismo (trekking, mountain bike) alla scoperta della Val Fontanabuona, dei suoi percorsi naturalistici, storici ed enogastronomici

Risk Factors and Mental Health Promotion Strategies in Children During COVID-19

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Myoclonic epilepsy. case report of a mild phenotype in a pediatric patient expanding clinical spectrum of kcna2 pathogenic variants

We report on the rare case of a male toddler presenting with myoclonic epilepsy characterized by daily episodes of upward movements of the eyebrows, and myoclonic jerks of both head and upper limbs. In addition, the child showed speech delay, tremors, and lack of motor coordination. Next Generation Sequencing analysis (NGS) performed in trio revealed in the proband the c.889C&gt;T de novo missense variant in the KCNA2 gene in heterozygous state. This is the first case of myoclonic epilepsy in a toddler due to a c.889C&gt;T KCNA2 missense variant. The patient was treated with valproic acid and ethosuximide with a good clinical response. At 6 years old, follow-up revealed that the proband was seizure-free with tremors and clumsiness in movements. According to the literature, this case supports the correlation between myoclonic epilepsy and KCNA2 alterations. This evidence suggests that performing genomic testing including the KCNA2 gene in preschool patients affected by myoclonic epilepsy, especially when associated with delayed neurodevelopment. Our goal is to expand the phenotypical spectrum of this rare condition and adding clinical features following a genotype-first approach