Compactness results in Symplectic Field Theory

This is one in a series of papers devoted to the foundations of Symplectic Field Theory sketched in [Y Eliashberg, A Givental and H Hofer, Introduction to Symplectic Field Theory, Geom. Funct. Anal. Special Volume, Part II (2000) 560--673]. We prove compactness results for moduli spaces of holomorphic curves arising in Symplectic Field Theory. The theorems generalize Gromov's compactness theorem in [M Gromov, Pseudo-holomorphic curves in symplectic manifolds, Invent. Math. 82 (1985) 307--347] as well as compactness theorems in Floer homology theory, [A Floer, The unregularized gradient flow of the symplectic action, Comm. Pure Appl. Math. 41 (1988) 775--813 and Morse theory for Lagrangian intersections, J. Diff. Geom. 28 (1988) 513--547], and in contact geometry, [H Hofer, Pseudo-holomorphic curves and Weinstein conjecture in dimension three, Invent. Math. 114 (1993) 307--347 and H Hofer, K Wysocki and E Zehnder, Foliations of the Tight Three Sphere, Annals of Mathematics, 157 (2003) 125--255].Comment: Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol7/paper25.abs.htm

Loop quantum gravity induced modifications to particle dynamics

The construction of effective Hamiltonians arising from Loop Quantum Gravity and incorporating Planck scale corrections to the dynamics of photons and spin 1/2 particles is summarized. The imposition of strict bounds upon some parameters of the model using already existing experimental data is also reviewed.Comment: 9 pages, 0 figures, talk presented at the X Mexican School of Particles and Fields, latex, aipproc style 6x

Phase detection at the quantum limit with multi-photon Mach-Zehnder interferometry

We study a Mach-Zehnder interferometer fed by a coherent state in one input port and vacuum in the other. We explore a Bayesian phase estimation strategy to demonstrate that it is possible to achieve the standard quantum limit independently from the true value of the phase shift and specific assumptions on the noise of the interferometer. We have been able to implement the protocol using parallel operation of two photon-number-resolving detectors and multiphoton coincidence logic electronics at the output ports of a weakly-illuminated Mach-Zehnder interferometer. This protocol is unbiased and saturates the Cramer-Rao phase uncertainty bound and, therefore, is an optimal phase estimation strategy.Comment: 4 pages, 5 figures replaced fig. 1 to correct graphics bu

Stable manifolds and homoclinic points near resonances in the restricted three-body problem

The restricted three-body problem describes the motion of a massless particle under the influence of two primaries of masses $1-\mu$ and $\mu$ that circle each other with period equal to $2\pi$. For small $\mu$, a resonant periodic motion of the massless particle in the rotating frame can be described by relatively prime integers $p$ and $q$, if its period around the heavier primary is approximately $2\pi p/q$, and by its approximate eccentricity $e$. We give a method for the formal development of the stable and unstable manifolds associated with these resonant motions. We prove the validity of this formal development and the existence of homoclinic points in the resonant region. In the study of the Kirkwood gaps in the asteroid belt, the separatrices of the averaged equations of the restricted three-body problem are commonly used to derive analytical approximations to the boundaries of the resonances. We use the unaveraged equations to find values of asteroid eccentricity below which these approximations will not hold for the Kirkwood gaps with $q/p$ equal to 2/1, 7/3, 5/2, 3/1, and 4/1. Another application is to the existence of asymmetric librations in the exterior resonances. We give values of asteroid eccentricity below which asymmetric librations will not exist for the 1/7, 1/6, 1/5, 1/4, 1/3, and 1/2 resonances for any $\mu$ however small. But if the eccentricity exceeds these thresholds, asymmetric librations will exist for $\mu$ small enough in the unaveraged restricted three-body problem

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation

Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen. However it is not known whether the converse occurs, and whether changes on non-donor specific antibodies are associated with any outcomes following HLA antibody incompatible renal transplantation. Methods: 55 patients, 31 women and 24 men, who underwent HLAi renal transplant in our center from September 2005 to September 2010 were included in the studies. We analysed the data using two different approaches, based on; i) DSA levels and ii) rejection episode post transplant. HLA antibody levels were measured during the early post transplant period and corresponding CMV, VZV and Anti-HBs IgG antibody levels and blood group IgG, IgM and IgA antibodies were quantified. Results: Despite a significant DSA antibody rise no significant non-donor specific HLA antibody, viral or blood group antibody rise was found. In rejection episode analyses, multiple logistic regression modelling showed that change in the DSA was significantly associated with rejection (p = 0.002), even when adjusted for other antibody levels. No other antibody levels were predictive of rejection. Increase in DSA from pre treatment to a post transplant peak of 1000 was equivalent to an increased chance of rejection with an odds ratio of 1.47 (1.08, 2.00). Conclusion: In spite of increases or decreases in the DSA levels, there were no changes in the viral or the blood group antibodies in these patients. Thus the DSA rise is specific in contrast to the viral, blood group or third party antibodies post transplantation. Increases in the DSA post transplant in comparison to pre-treatment are strongly associated with occurrence of rejection

Complete and Prolonged Response to Immune Checkpoint Blockade in POLE-Mutated Colorectal Cancer

Enid Robertson Logan Faculty Fellowship Fund6 month embargo; published online: 21 June 2019This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

The influence of wind direction on the capture of the wood warbler (Phylloscopus sibilatrix), an uncommon migratory species in the western Mediterranean

The wood warbler (Phylloscopus sibilatrix) is a migratory species in the western Mediterranean wintering in the Gulf of Guinea region, West Africa. In autumn and spring, this species, along with the populations breeding in Ireland and Britain, uses the Italian peninsula as its main axis of migration. From the data of captured birds at several ringing stations in the western Mediterranean (Balearic Islands and coastal Iberian Peninsula), we analyzed capture rates of the species during spring migration from 1993 to 2007. Based on the selection of days with a significant number of captures and those without captures, we analyzed the effect of wind direction over the western Mediterranean to determine a relationship between winds and the number of captures. From a total of 663 wood warblers captured between 1993 and 2007, a total of 31 days have been selected as significant days with a high number of captures, and 31 days have been selected as no-capture days. On days of maximum captures, winds coming from an easterly direction, i.e. Algeria and Tunisia, were dominant, indicating days with a clear eastern component. Contrary to expected results, captures were also made on days when the wind direction was predominantly from a northerly direction. Analysis of the origin of the winds in north eastern Spain (western Mediterranean) revealed that the majority of northerly winds originated from Africa and not from Europe as is usual for this region. Days or periods selected as no-capture days were characterized by winds coming from a northerly (European origin) or westerly direction

Calcium-sensing receptor in artery

UNLABELLED: Vascular calcification (VC) is common in chronic kidney disease (CKD) and contributes to cardiovascular mortality. The calcium-sensing receptor (CaSR) is present in human artery, senses extracellular calcium and may directly modulate VC. OBJECTIVE: to investigate the association between arterial cyclic strain, CaSR expression and VC. METHODS AND RESULTS: human aortic smooth muscle cells (HAoSMC) were cultured under static or strained conditions, with exposure to CaSR agonists, the calcimimetic R568, and after CaSR silencing and over-expression. High extracellular calcium reduced CaSR expression and promoted osteochondrogenic transformation and calcium deposition. This was partially prevented by cyclic strain and exposure to R568. CaSR silencing enhanced calcification and osteochondrogenic transformation, whereas CaSR over-expression attenuated this procalcific response, demonstrating a central role for the CaSR in the response to cyclic strain and regulation of VC. In arterial explants from CKD patients (n = 11) and controls (n = 9), exposure to R568 did not significantly alter calcium deposition, osteochondrogenic markers or total artery calcium content. CONCLUSIONS: physiological mechanical strain is important for arterial homeostasis and may protect arteries from VC. The beneficial effects of cyclic strain may be mediated via the CaSR.We are grateful to Professor A.R. Bradwell (Binding Site) for generating CaSR antibody and MRC Infrastructure Award (G4500017) 'Bioinformatics and Structural Biology in Life Sciences' for CaSR peptide design. R-568 and S-568 was a kind gift from Amgen USA.This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.pone.013883

α-Klotho Expression in Human Tissues.

CONTEXT: α-Klotho has emerged as a powerful regulator of the aging process. To date, the expression profile of α-Klotho in human tissues is unknown, and its existence in some human tissue types is subject to much controversy. OBJECTIVE: This is the first study to characterize systemwide tissue expression of transmembrane α-Klotho in humans. We have employed next-generation targeted proteomic analysis using parallel reaction monitoring in parallel with conventional antibody-based methods to determine the expression and spatial distribution of human α-Klotho expression in health. RESULTS: The distribution of α-Klotho in human tissues from various organ systems, including arterial, epithelial, endocrine, reproductive, and neuronal tissues, was first identified by immunohistochemistry. Kidney tissues showed strong α-Klotho expression, whereas liver did not reveal a detectable signal. These results were next confirmed by Western blotting of both whole tissues and primary cells. To validate our antibody-based results, α-Klotho-expressing tissues were subjected to parallel reaction monitoring mass spectrometry (data deposited at ProteomeXchange, PXD002775) identifying peptides specific for the full-length, transmembrane α-Klotho isoform. CONCLUSIONS: The data presented confirm α-Klotho expression in the kidney tubule and in the artery and provide evidence of α-Klotho expression across organ systems and cell types that has not previously been described in humans.K.L. received a Genzyme-Sanofi Fellowship in Nephrology grant. T.F.H. is funded by the NIHR award to the Cambridge Biomedical Research Centre and by NIHR grant 14/49/147. The Cambridge Aorta Study is funded by the British Heart Foundation.This is the author accepted manuscript. The final version is available from the Endocrine Society via http://dx.doi.org/10.1210/jc.2015-1800

Far-infrared photo-conductivity of electrons in an array of nano-structured antidots

We present far-infrared (FIR) photo-conductivity measurements for a two-dimensional electron gas in an array of nano-structured antidots. We detect, resistively and spectrally resolved, both the magnetoplasmon and the edge-magnetoplasmon modes. Temperature-dependent measurements demonstrates that both modes contribute to the photo resistance by heating the electron gas via resonant absorption of the FIR radiation. Influences of spin effect and phonon bands on the collective excitations in the antidot lattice are observed.Comment: 5 pages, 3 figure