5,940 research outputs found
T cell receptor specificity is critical for the development of epidermal gammadelta T cells.
A particular feature of gammadelta T cell biology is that cells expressing T cell receptor (TCR) using specific Vgamma/Vdelta segments are localized in distinct epithelial sites, e.g., in mouse epidermis nearly all gammadelta T cells express Vgamma3/Vdelta1. These cells, referred to as dendritic epidermal T cells (DETC) originate from fetal Vgamma3+ thymocytes. The role of gammadelta TCR specificity in DETC's migration/localization to the skin has remained controversial. To address this issue we have generated transgenic (Tg) mice expressing a TCR delta chain (Vdelta6.3-Ddelta1-Ddelta2-Jdelta1-Cdelta), which can pair with Vgamma3 in fetal thymocytes but is not normally expressed by DETC. In wild-type (wt) Vdelta6.3Tg mice DETC were present and virtually all of them express Vdelta6.3. However, DETC were absent in TCR-delta(-/-) Vdelta6.3Tg mice, despite the fact that Vdelta6.3Tg gammadelta T cells were present in normal numbers in other lymphoid and nonlymphoid tissues. In wt Vdelta6.3Tg mice, a high proportion of in-frame Vdelta1 transcripts were found in DETC, suggesting that the expression of an endogenous TCR-delta (most probably Vdelta1) was required for the development of Vdelta6.3+ epidermal gammadelta T cells. Collectively our data demonstrate that TCR specificity is essential for the development of gammadelta T cells in the epidermis. Moreover, they show that the TCR-delta locus is not allelically excluded
DISTO data on Kpp
The data from the DISTO Collaboration on the exclusive pp -> p K+ Lambda
production acquired at T_p = 2.85 GeV have been re-analysed in order to search
for a deeply bound K- pp (= X) state, to be formed in the binary process pp ->
K+ X. The preliminary spectra of the DeltaM_{K+} missing-mass and of the M_{p
Lambda} invariant-mass show, for large transverse-momenta of protons and kaons,
a distinct broad peak with a mass M_X = 2265 +- 2 MeV/c^2 and a width Gamma_X =
118 +- 8 MeV/c^2.Comment: 8 pages, 4 figures. Talk presented at the "10th International
Conference on Hypernuclear and Strange Particle Physics" (HYP-X), Tokai,
Ibaraki, Japan, September 14th-18th, 2009. To appear in the proceeding
Indication of a deeply bound compact K-pp state formed in the pp -> p Lambda K+ reaction at 2.85 GeV
We have analyzed data of the DISTO experiment on the exclusive pp -> p Lambda
K+ reaction at 2.85 GeV to search for a strongly bound compact K-pp (= X) state
to be formed in the pp -> K+ + X reaction. The observed spectra of the K+
missing-mass and the p Lambda invariant-mass with high transverse momenta of p
and K+ revealed a broad distinct peak with a mass M_X = 2265 +- 2 (stat) +- 5
(syst) MeV/c2 and a width Gamma_X = 118 +- 8 (stat) +- 10 (syst) MeV.Comment: 4 pages, 4 figure
T cell receptor specificity is critical for the development of epidermal gammadelta T cells
A particular feature of gammadelta T cell biology is that cells expressing T cell receptor (TCR) using specific Vgamma/Vdelta segments are localized in distinct epithelial sites, e.g., in mouse epidermis nearly all gammadelta T cells express Vgamma3/Vdelta1. These cells, referred to as dendritic epidermal T cells (DETC) originate from fetal Vgamma3+ thymocytes. The role of gammadelta TCR specificity in DETC's migration/localization to the skin has remained controversial. To address this issue we have generated transgenic (Tg) mice expressing a TCR delta chain (Vdelta6.3-Ddelta1-Ddelta2-Jdelta1-Cdelta), which can pair with Vgamma3 in fetal thymocytes but is not normally expressed by DETC. In wild-type (wt) Vdelta6.3Tg mice DETC were present and virtually all of them express Vdelta6.3. However, DETC were absent in TCR-delta(-/-) Vdelta6.3Tg mice, despite the fact that Vdelta6.3Tg gammadelta T cells were present in normal numbers in other lymphoid and nonlymphoid tissues. In wt Vdelta6.3Tg mice, a high proportion of in-frame Vdelta1 transcripts were found in DETC, suggesting that the expression of an endogenous TCR-delta (most probably Vdelta1) was required for the development of Vdelta6.3+ epidermal gammadelta T cells. Collectively our data demonstrate that TCR specificity is essential for the development of gammadelta T cells in the epidermis. Moreover, they show that the TCR-delta locus is not allelically excluded
Winterberg's conjectured breaking of the superluminal quantum correlations over large distances
We elaborate further on a hypothesis by Winterberg that turbulent
fluctuations of the zero point field may lead to a breakdown of the
superluminal quantum correlations over very large distances. A phenomenological
model that was proposed by Winterberg to estimate the transition scale of the
conjectured breakdown, does not lead to a distance that is large enough to be
agreeable with recent experiments. We consider, but rule out, the possibility
of a steeper slope in the energy spectrum of the turbulent fluctuations, due to
compressibility, as a possible mechanism that may lead to an increased
lower-bound for the transition scale. Instead, we argue that Winterberg
overestimated the intensity of the ZPF turbulent fluctuations. We calculate a
very generous corrected lower bound for the transition distance which is
consistent with current experiments.Comment: 7 pages, submitted to Int. J. Theor. Phy
Thermal and Chemical Freeze-out in Spectator Fragmentation
Isotope temperatures from double ratios of hydrogen, helium, lithium,
beryllium, and carbon isotopic yields, and excited-state temperatures from
yield ratios of particle-unstable resonances in 4He, 5Li, and 8Be, were
determined for spectator fragmentation, following collisions of 197Au with
targets ranging from C to Au at incident energies of 600 and 1000 MeV per
nucleon. A deviation of the isotopic from the excited-state temperatures is
observed which coincides with the transition from residue formation to
multi-fragment production, suggesting a chemical freeze-out prior to thermal
freeze-out in bulk disintegrations.Comment: 14 pages, 10 figures, submitted to Phys. Rev. C, small changes as
suggested by the editors and referee
Correlations in Nuclear Arrhenius-Type Plots
Arrhenius-type plots for multifragmentation process, defined as the
transverse energy dependence of the single-fragment emission-probability,
-ln(p_{b}) vs 1/sqrt(E_{t}), have been studied by examining the relationship of
the parameters p_{b} and E_{t} to the intermediate-mass fragment multiplicity
. The linearity of these plots reflects the correlation of the fragment
multiplicity with the transverse energy. These plots may not provide thermal
scaling information about fragment production as previously suggested.Comment: 12 pages, Latex, 3 Postscript figures include
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