In-situ steel solidification imaging in continuous casting using magnetic induction tomography

: Solidification process in continuous casting is a critical part of steel production. The speed and quality of the solidification process determines the quality of final product. Computational fluid dynamics (CFD) simulations are often used to describe the process and design of its control system, but so far, there is no any tool that provides an on-line measurement of the solidification front of hot steel during the continuous casting process. This paper presents a new tool based on magnetic induction tomography (MIT) for real time monitoring of this process. The new MIT system was installed at the end of the secondary cooling chamber of a casting unit and tested during several days in a real production process. MIT is able to create an internal map of electrical conductivity of hot steel deep inside the billet. The image of electrical conductivity is then converted to temperature profile that allows the measurement of the solid, mushy and liquid layers. In this study, such a conversion is done by synchronizing in one time step the MIT measurement and the thermal map generated with the actual process parameters available at that time. The MIT results were then compared with the results obtained of the CFD and thermal modelling of the industrial process. This is the first in-situ monitoring of the interior structure during a real continuous casting.The SHELL-THICK project has received funding from EU Research Fund for Coal and Steel under grant number 709830. This study reflects only the author's views and the European Commission is not responsible for any use that may be made of the information contained therein

Application of Different Learning Methods for the Modelling of Microstrip Characteristics

In this paper, the performance of four machine learning regressions like Support Vector Machine (SVM), Least Square-Support Vector Machine (LS-SVM), Gaussian Process Regression (GPR) and Random Forest method (RF) are investigated by means of an illustrative example referring to the characteristic impedance of a microstrip line in terms of electrical and geometrical parameters. The required dataset for training is obtained from a set of parametric electromagnetic simulations. The performance comparison of the four methods is done in the presence and absence of numerical noise and inaccuracies affecting the training samples. The results of our comparison provide a guidance for the proper method selection to model the electromagnetic characteristics of interconnects for high-speed signals: advantages and drawbacks of each of the proposed techniques clearly emerge from this analysis

The effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis: A randomized, double-blind, placebo-controlled trial

Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis (HD) patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either vitamin D supplements at a dosage of 50,000 IU (n = 30) or placebo (n = 30) every 2 weeks for 12 weeks. Gene expression of inflammatory cytokines and biomarkers of oxidative stress were assessed in peripheral blood mononuclear cells (PBMCs) of diabetic HD patients with RT-PCR method. Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1β (P = 0.02), tumor necrosis factor alpha (TNF-α) (P = 0.02) and interferon gamma (IFN-γ) (P = 0.03) in PBMCs of diabetic HD patients. Additionally, vitamin D supplementation, compared to the placebo, downregulated gene expression of transforming growth factor beta (TGF-β) (P = 0.04), protein kinase C (PKC) (P = 0.001), and mitogen-activated protein kinases 1 (MAPK1) (P = 0.02) in PBMCs of diabetic HD patients. Although not significant, vitamin D supplementation let to a reduction of nuclear factor kappa B (NF-kB) (p = 0.75) expression in PBMCs isolated from diabetic patients compared to the placebo group. There was no statistically significant change following supplementation with vitamin D on gene expression of interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF) in PBMCs of diabetic HD patients. Conclusions: Overall, we found that vitamin D supplementation for 12 weeks among diabetic HD patients had beneficial effects on few gene expression related to inflammation and oxidative stress. © 2018 Haddad Kashani, Seyed Hosseini, Nikzad, Soleimani, Soleimani, Tamadon, Keneshlou and Asemi

Psychometric properties of the king spiritual intelligence questionnaire (KSIQ) in physical veterans of Iran-Iraq warfare

Aims: The study's purpose was to determine reliability and validity of the King spiritual intelligence questionnaires in veterans of Iran-Iraq Warfare. Methods: In this cross sectional study, 300 veterans of the Iran-Iraq war completed the King spiritual intelligence questionnaires. Principal components analysis (PCA) with varimax rotation was used to assess domain structure of the King spiritual intelligence questionnaires. Internal and external consistency reliability was assessed with Cronbach's alpha and intra-class correlation coefficient (ICC). Results: Internal consistency of King spiritual intelligence questions estimated with Cronbach's alpha, 0.872 and intra-class correlation coefficient (ICC).872 (CI 95%: 0.84 -0.89). The construct validity of the questionnaire was calculated using exploratory factor analysis that showed 3 factors with Eigen values of greater than one, which explained in total 44.7% of the variance. (1, 8 items, α= 0.87; 2, 5. items; α = 0.89; 3, 2 items, α= 0.51). Conclusion: The Persian version of King spiritual intelligence questionnaire demonstrated suitable validity and reliability among the Veterans of Iran-Iraq Warfare. With the consideration of the proper psychometric characteristics, this questionnaire can be used to further research spiritual intelligence in this population

Correlation between high-risk pregnancy and developmental delay in children aged 4-60 months

Background: The future development of children is considered more than ever now due to the advances in medical knowledge and thus the increase in survival rates of high-risk infants. This study investigated the correlation between high-risk pregnancy and developmental delay in children aged 4- 60 months.Methods: This descriptive study was conducted on 401 mothers and their children (460 months) who visited health service centers affiliated to Isfahan University of Medical Sciences, Iran, in 2011. Sampling was carried out in several stages, and the Ages and Stage Questionnaire was completed by the participants. Data were analyzed with SPSS 18 software and independent t-test; Mann-Whitney and logistic-regression tests were used.Results: The average age of children in the low-risk pregnancy group was 22916 months, and that in the highrisk pregnancy group was 18.9914.8 months. The majority of children were female (53.1%). The prevalence ofhigh-risk pregnancies was 80.5%, and the prevalence of developmental delay was 18.7%. Multiple pregnancies, low birth weight, habitual abortions, maternal medical disorders in pregnancy, and gestational diabetes had significant correlations with developmental delay in children (PB0.04). In the logistic model, male gender, low birth weight, family marriage, and maternal medical disorders during pregnancy showed significant correlations with developmental delay in children (PB0.05). Additionally, abnormal body mass index (BMI) and social and economic status showed probability values close to the significance level (P0.05), whereas other high-risk pregnancy variables had no correlation with developmental delay in children. A correlation between high-risk pregnancy and developmental delay (P0.002) and fine motor delay was observed (P 0.02), but no correlation was observed between high-risk pregnancy and other developmental domains.Conclusion: This study showed that some high-risk pregnancy variables had a significant correlation with developmental delay. Moreover, a significant correlation was observed between high-risk pregnancy and fine motor developmental delay.Keywords: high-risk pregnancy; development delay; Ages and Stages Questionnair

Experimental investigation of the tire wear process using camera-assisted observation assessed by numerical modeling

This paper presents a novel experimental method to study the abrasion mechanism of car tires. It is based on the detection of microscopic movements associated with material damage (cracking) on the rubber tread. This is referred to as degrading layer relaxation. It correlates with the wear rate and, interestingly, the direction of the pattern's movement is opposite to the lateral forces during cornering. To measure and analyze the microscopic movements, a new camera-based method with feature point matching using video stabilization was developed. Besides extensive experimental investigation, the formation and propagation of microcracks are investigated using a simplified numerical model in which a phase field approach coupled with a viscoelastic constitutive behavior is implemented in a finite element framework

Transmission/Reflection Dual-mode Ultrasonic Tomography using Weighted Least Square-Lagrange Joint Reconstruction

Industrial Ultrasonic Tomography (UT) possesses unique advantages in multiphase medium imaging and has received broad attention. In this work, a novel transmission/reflection dual-mode image reconstruction algorithm based on information fusion is proposed. The transmissive attenuation and reflective time-delay information are both integrated into an improved Lagrange framework with the weighted least square transformation of objective function, which is then solved by a pair of coupled preconditioned gradient approaches. Experiment results show that the proposed algorithm performs better than existing image fusion strategies in terms of accuracy (average relative error 0.456, average correlation coefficient 0.870) and robustness (average standard derivation of relative error and correlation coefficient 0.056 and 0.041). Accordingly, the dual-mode UT approach is proved feasible to provide more accurate image of biphasic medium distribution

Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells

MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an oncogenes and tumor suppressor genes, so manipulation of this molecules can be a promising approach in cancer therapy, and experimental results represented that the modification in breast cancer phenotype is possible by miRNA expression alteration. miR-16, which is located in 13q14 chromosome, plays critical roles as a tumor suppressor by targeting several oncogenes which regulate cell cycle and apoptosis. Hence, in the present study, we investigated whether miR-16 could decline growth and survival of MCF-7 cell line as model of human breast cancer. MCF-7 cell line was infected with lentiviruses containing miR-16 precursor sequence. The effects of ectopic expression of miR-16 on breast cancer phenotype were examined by cell cycle analysis and apoptosis assays. miR-16 cytotoxicity effect was measured by the MTT assay. We showed that the miR-16 overexpression reduces Cyclin D1 and BCL2 at messenger RNA (mRNA) and protein levels in MCF-7 cell line. In addition, this is found that enforced expression of miR-16 decreases cell growth and proliferation and induces apoptosis in MCF-7 cells. In conclusion, our results revealed that upregulation of miR-16 would be a potential approach for breast cancer therapy. © 2015, The Society for In Vitro Biology

MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1

Background MicroRNA-129-1 (miR-129-1) seems to behave as a tumour suppressor since its decreased expression is associated with different tumours such as glioblastoma multiforme (GBM). GBM is the most common form of brain tumours originating from glial cells. The impact of miR-129-1 downregulation on GBM pathogenesis has yet to be elucidated. Methods MiR-129-1 was overexpressed in GBM cells, and its effect on proliferation was investigated by cell cycle assay. MiR-129-1 predicted targets (CDK6, IGF1, HDAC2, IGF2BP3 and MAPK1) were also evaluated by western blot and luciferase assay. Results Restoration of miR-129-1 reduced cell proliferation and induced G1 accumulation, significantly. Several functional assays confirmed IGF2BP3, MAPK1 and CDK6 as targets of miR-129-1. Despite the fact that IGF1 expression can be suppressed by miR-129-1, through 30-untranslated region complementary sequence, we could not find any association between IGF1 expression and GBM. MiR-129-1 expression inversely correlates with CDK6, IGF2BP3 and MAPK1 in primary clinical samples. Conclusion This is the first study to propose miR129-1 as a negative regulator of IGF2BP3 and MAPK1 and also a cell cycle arrest inducer in GBM cells. Our data suggests miR-129-1 as a potential tumour suppressor and presents a rationale for the use of miR-129-1 as a novel strategy to improve treatment response in GBM