Fast glycorrhachia and cerebrospinal fluid protein as predictors of sensory block in anesthesia with subarachnoid Ropivacaine

BACKGROUND: Identify if glycorrhachia and cerebrospinal fluid protein could influence the time of sensory block to T10, the duration and the metameric block's level, after a standard dose of Ropivacaine. METHODS: 80 patients, ASA I - III undergoing to transurethral prostate resection with spinal anesthesia in a prospected open study were recruited. A 0.2 ml liquor's sample was taken; glycorrhachia, by glycemic stix and CSF protein, by urinary stix, were got, before Ropivacaine 0.5% 15 mg injection (0.10 - 0.15 mlsec). After anti-trendelemburg, with 30 ° tilting for 15 min, the onset of sensory block to T10, the maximum metameric level to 15' and the time of sensory block were reported. The data collection were analyzed using the software language R. RESULTS: A significant correlation liquor specific weigh preoperative glycemia (0.749), liquoral specific weigh glycorrhachia (rho = 0.751; R2 = 0.564; P 0.05) and specific weigh CSF protein (rho = 0.684; R2 = 0.468; P 0.05) were reported. Inverse relation CSF weightsensory block level (rho -0.789, P 0.05, R2 0.621) was evidenced. Inverse relation onset time to T10 glycorrhachia (84%) and cephalic block glycorrhachia (76%) were found. Inverse correlation onset time to T 10 CSF protein and cephalic block proteinorrachia was respectively 84% and 67%. A rho of 0.712 with R2 of 51% BMI onset to T10 and rho of 0.681 with R2 of 51% BMI maximum cephalic block with P 0.05 were reported. CONCLUSIONS: The predictability of a iso-hypobaric local anesthetic could reduce the risk of procedure failure and adverse events by further cephalic spread

Analysis and Mitigation of Soft-Errors on High Performance Embedded GPUs

Multiprocessor system-on-chip such as embedded GPUs are becoming very popular in safety-critical applications, such as autonomous and semi-autonomous vehicles. However, these devices can suffer from the effects of soft-errors, such as those produced by radiation effects. These effects are able to generate unpredictable misbehaviors. Fault tolerance oriented to multi-threaded software introduces severe performance degradations due to the redundancy, voting and correction threads operations. In this paper, we propose a new fault injection environment for NVIDIA GPGPU devices and a fault tolerance approach based on error detection and correction threads executed during data transfer operations on embedded GPUs. The fault injection environment is capable of automatically injecting faults into the instructions at SASS level by instrumenting the CUDA binary executable file. The mitigation approach is based on concurrent error detection threads running simultaneously with the memory stream device to host data transfer operations. With several benchmark applications, we evaluate the impact of softerrors classifying Silent Data Corruption, Detection, Unrecoverable Error and Hang. Finally, the proposed mitigation approach has been validated by soft-error fault injection campaigns on an NVIDIA Pascal Architecture GPU controlled by Quad-Core A57 ARM processor (JETSON TX2) demonstrating an advantage of more than 37% with respect to state of the art solution

L’ambiente carsico e l’idrogeologia dei gessi di Sassalbo (MS)

Nel Canale dell’Acqua Torbida (Alta Lunigiana), si trova il maggiore affioramento di evaporiti triassiche della Toscana. Rispetto ai gessi dell’Alta val Secchia (RE), di cui sono il lembo meridionale, appaiono molto meno tettonizzati. L’area carsica, che comprende in prevalenza calcari cavernosi, ha una superficie complessiva di circa 2,2 km2 in cui sono ben rappresentate forme carsiche superficiali, sia macro che micro. Anche i fenomeni carsici sotterranei sembrano essere ben sviluppati: la loro genesi è stata attribuita a periodi di avanzata e arretramento dei ghiacciai durante l’ultimo glaciale. Attualmente nel catasto toscano sono registrate 5 cavità, di cui 4 rilevate. Nell’ambito del Progetto Trias II (studio interdisciplinare svolto dalla Società Speleologica Italiana per conto del Parco Nazionale dell’Appennino Tosco-Emiliano) è stato possibile studiare l’area dal punto di vista morfologico, speleologico e idrochimico, monitorando in continuo alcune delle principali risorgenti carsiche parallelamente ai torrenti cui esse potevano risultare connesse. Nel presente lavoro, dopo breve illustrazione delle morfologie epigee ed ipogee, vengono presentati i risultati del monitoraggio idrologico. Le analisi hanno permesso di evidenziare come in molti casi le acque del carso di Sassalbo siano chimicamente molto simili a quelle del sistema ad ansa ipogea del Tanone della Gacciolina in Alta val di Secchia. Fanno eccezione altre sorgenti, alimentate quasi esclusivamente dalla serie marnoso arenacea e dal macigno, che presentano comportamenti idrodinamici differenti in funzione dei loro specifici bacini di alimentazione.Karst and hydrology of the Sassalbo Gypsa (Massa Carrara – Italy) The largest triassic evaporitic outcrop of Tuscany is located inside the Acqua Torbida creek (Upper Lunigiana). They represent the southernmost and less tectonized part of the Upper Secchia Gypsa (RE). The karst area (some 2,2) consists mostly of limestone (Calcari Cavernosi) with well developed macro – and micro – forms. The underground phenomena are mainly related to the mouventes of glacial tongues during the last Glacial. 5 cavities are presently known and inserted in the Tuscany Cadaster, 4 of which mapped. In the framework of the Trias II Project (an interdisciplinary study sponsored by the Appennino Tosco-Emiliano National Park and performed by the Italian Speleological Society) this area has been investigated from the morphological, speleological, hydrochemical point of view while some of the major springs and related rivers were monitored. In the paper after a short description of the epigean and hypogean forms, the achieved result during the hydrological study are presented. This study evidenced that in many occurrences the behavior of the Sassalbo karst waters is very similar to that of the Tanone della Gacciolina cave in the Upper Secchia Valley. Only a few springs exhibit a different behavior being rather completely fed by the marnoso-arenacea and macigno formations

Le Elezioni Politiche 2013

Le elezioni politiche del 24 e 25 febbraio 2013 hanno sancito un forte cambiamento della struttura del sistema partitico italiano. In un contesto di altissima volatilità elettorale e di accelerato declino della partecipazione al voto, il sistema è divenuto sostanzialmente tripolare, dopo vent’anni di strutturazione e tenuta del bipolarismo. A questo esito hanno concorso da un lato l’erosione dei principali schieramenti politici che a partire dal novembre 2011 avevano sostenuto l’esperienza del governo Monti (nonché la deludente prova elettorale dello stesso Presidente del Consiglio uscente), e dall’altro lo straordinario successo del Movimento 5 stelle. Quest’ultimo, al primo test elettorale di livello nazionale, ha raccolto un risultato sorprendente, giungendo ad oltre un quarto dei voti validi. Siamo di fronte ad una parentesi momentanea dovuta all’effetto combinato di crisi economica e crisi politica, oppure le contraddizioni interne alla Seconda Repubblica l’hanno condotta effettivamente al suo crepuscolo? Come uscirà il sistema partitico italiano da questa nuova fase di destabilizzazione? Questo quarto Dossier CISE, che raccoglie contributi apparsi sul sito web del Cise prima e dopo le elezioni, fornisce una prima analisi del voto, presentando elaborazioni su dati aggregati, stime dei flussi elettorali, alcune prime analisi su dati di sondaggio, nonché una panoramica dei nuovi eletti e un’appendice ricca di tabelle e mappe riassuntive del risultato elettorale. Come i precedenti Dossier, si tratta di uno strumento prodotto rapidamente all’indomani del voto, con l’intento di suggerire primi spunti di interpretazione da approfondire in seguito, cercando di contribuire alla lettura di un risultato elettorale cruciale, in una delicata fase di cambiamento del sistema partitico italiano

Yield, quality, antioxidant, and sensorial properties of diced tomato as affected by genotype and industrial processing in Southern Italy

Research was carried out on processing tomato in Southern Italy in order to compare four round-prismatic type hybrids oriented to diced produce (4420, Miceno, Nemabrix, Impact as a control). The hybrid Nemabrix attained the highest marketable yield (180.9 t ha–1, due to both the highest number of fruit per plant and their mean weight (103.7 and 70 g, respectively), and it was not significantly different from the other genotypes in terms of processing efficiency both as a total and along dicing chain (67.8% and 65.6%, respectively). Lycopene attained the highest concentration in Nemabrix (155 mg kg–1), and β–carotene was most concentrated in 4420 and Miceno (2.8 mg kg–1). Significant differences arose between the genotypes with regard to the sensorial variables aspect, colour, taste, firmness, and fresh taste

Antimicrobial effects of chemically functionalized and/or photo-heated nanoparticles

Antibiotic resistance refers to when microorganisms survive and grow in the presence of specific antibiotics, a phenomenon mainly related to the indiscriminate widespread use and abuse of antibiotics. In this framework, thanks to the design and fabrication of original functional nanomaterials, nanotechnology offers a powerful weapon against several diseases such as cancer and pathogenic illness. Smart nanomaterials, such as metallic nanoparticles and semiconductor nanocrystals, enable the realization of novel drug-free medical therapies for fighting against antibiotic-resistant bacteria. In the light of the latest developments, we highlight the outstanding capabilities of several nanotechnology-inspired approaches to kill antibiotic-resistant bacteria. Chemically functionalized silver and titanium dioxide nanoparticles have been employed for their intrinsic toxicity, which enables them to exhibit an antimicrobial activity while, in a different approach, photo-thermal properties of metallic nanoparticles have been theoretically studied and experimentally tested against several temperature sensitive (mesophilic) bacteria. We also show that it is possible to combine a highly localized targeting with a plasmonic-based heating therapy by properly functionalizing nanoparticle surfaces with covalently linked antibodies. As a perspective, the utilization of properly engineered and chemically functionalized nanomaterials opens a new roads for realizing antibiotic free treatments against pathogens and related diseases

A Novel Approach to Contamination Suppression in Transmission Detectors for Radiotherapy

The current trend in X-ray radiotherapy is to treat cancers that are in difficult locations in the body using beams with a complex intensity profile. Intensity Modulated Radiotherapy (IMRT) is a treatment which improves the dose distribution to the tumour whilst reducing the dose to healthy tissue. Such treatments administer a larger dose per treatment fraction and hence require more complex methods to verify the accuracy of the treatment delivery. Measuring beam intensity fluctuations is difficult as the beam is heavily distorted after leaving thepatient and transmission detectors will attenuate the beam and change the energy spectrum of the beam. Monolithic Active Pixel Sensors (MAPS) are ideal solid-state detectors to measure the 2D beam profile of a radiotherapy beam upstream of the patient. MAPS sensors can be made very thin (∼ 30 μm) with still very good signal-to-noise performance. This means that the beam would pass through the sensor virtually undisturbed(< 1% attenuation). Pixel pitches of between 2 μm to 100 μm are commercially available. Large area devices (∼ 15 × 15 cm 2 ) have been produced. MAPS can be made radiation hard enough to befully functional after a large number of fractions. All this makes MAPS a very realistic transmission detector candidate for beam monitoring upstream of the patient. A remaining challenge for thin, upstream sensors is that the detectors are sensitive to the signal of both therapeutic photons and electron contamination. Here a method is presented to distinguish between the signal due to electrons and photons and thus provide real-time dosimetric information in very thin sensors that does not require Monte Carlo simulation of each linear accelerator treatment head

18F-fluorodeoxyglucose (18F-FDG) functionalized gold nanoparticles (GNPs) for plasmonic photothermal ablation of cancer. A review

The meeting and merging between innovative nanotechnological systems, such as nanoparticles, and the persistent need to outperform diagnostic-therapeutic approaches to fighting cancer are revolutionizing the medical research scenario, leading us into the world of nanomedicine. Photothermal therapy (PTT) is a non-invasive thermo-ablative treatment in which cellular hyperthermia is generated through the interaction of near-infrared light with light-to-heat converter entities, such as gold nanoparticles (GNPs). GNPs have great potential to improve recovery time, cure complexity, and time spent on the treatment of specific types of cancer. The development of gold nanostructures for photothermal efficacy and target selectivity ensures effective and deep tissue-penetrating PTT with fewer worries about adverse effects from nonspecific distributions. Regardless of the thriving research recorded in the last decade regarding the multiple biomedical applications of nanoparticles and, in particular, their conjugation with drugs, few works have been completed regarding the possibility of combining GNPs with the cancer-targeted pharmaceutical fluorodeoxyglucose (FDG). This review aims to provide an actual scenario on the application of functionalized GNP-mediated PTT for cancer ablation purposes, regarding the opportunity given by the 18F-fluorodeoxyglucose (18F-FDG) functionalization