THE MIDDLE TRIASSIC OF THE BREMBANA VALLEY: PRELIMINARY STUDY OF THE ESINO PLATFORM (Bergamasc Alps)

The stratigraphy and paleogeography of the ladinian Esino Limestone outcropping in Valle Brembana-Valle Parina, have been integrated with the biostratigraphic analysis of cephalopod fauna. A complex internal structure of the upper anisian-ladinian Esino carbonate platform has been identified. Six different lithozones have been recognized, they record the stratigraphic-paleogeographic evolution of the Esino Limestone. This carbonate platform developed through three stages: 1) construction of a lower edifice (Late Anisian-? Early Ladinian) representing the first phase of carbonate piatform diffusion on structural highs, which were already the site of carbonate deposition during the Middle Anisian (peritidal dolomites of the Angolo Limestone); 2) buildup of the carbonate complex (main edifice). In this second phase (Early Ladinian-Late Ladinian p.p.) the most important one, the platform growth took place by prevalent aggradation; 3) development of the upper edifice and progradation of the piatform in the Late Ladinian. In this third phase, inner plarform facies with diagenetic caps at the top of peritidal cycles are common. The buildup developed in the second phase yields bioclastic packstones with ammonoids, gastropods, echinoderms, and bivalves clustered within lithozone 4 and in the proximity of the southern margin of the platform in Val Parina. Studies in progress of ammonoids and gastropods allowed for the recognition of different fossil assemblages which date from Early Ladinian to Late Ladinian. A few problematic ammonoid assemblage of probably Early Ladinian age, has been found in a stratigraphic level above the base of the Esino Limestone

Serum C-reactive protein is associated with earlier mortality across different interstitial lung diseases

Background and Objective: The acute-phase protein C-reactive protein (CRP) is known to be associated with poor outcomes in cancer and cardiovascular disease, but there is limited evidence of its prognostic implications in interstitial lung diseases (ILDs). We therefore set out to test whether baseline serum CRP levels are associated with mortality in four different ILDs. Methods: In this retrospective study, clinically measured CRP levels, as well as baseline demographics and lung function measures, were collected for ILD patients first presenting to the Royal Brompton Hospital between January 2010 and December 2019. Cox regression analysis was used to determine the relationship with 5-year mortality. Results: Patients included in the study were: idiopathic pulmonary fibrosis (IPF) n = 422, fibrotic hypersensitivity pneumonitis (fHP) n = 233, rheumatoid arthritis associated ILD (RA-ILD) n = 111 and Systemic Sclerosis associated ILD (SSc-ILD) n = 86. Patients with a recent history of infection were excluded. Higher CRP levels were associated with shorter 5-year survival in all four disease groups on both univariable analyses, and after adjusting for age, gender, smoking history, immunosuppressive therapy and baseline disease severity (IPF: HR (95% CI): 1.3 (1.1–1.5), p = 0.003, fHP: 1.5 (1.2–1.9), p = 0.001, RA-ILD: 1.4 (1.1–1.84), p = 0.01 and SSc-ILD: 2.7 (1.6–4.5), p < 0.001). Conclusion: Higher CRP levels are independently associated with reduced 5-year survival in IPF, fHP, RA-ILD and SSc-ILD

Social Mpower: An Educational Game for Energy Efficiency

A number of serious games have been developed for energy systems that act as an educational tool and help energy consumers to better understand concepts such as resource allocation, electricity prices and grid sustainability. In such gamified environments, players use technology to solve environmental problems including greener environment, optimised energy and water infrastructure, sustainable resources and reduced energy use. Social Mpower game is a representation of an autonomous energy community for local power generation and distribution in which the participants have to avoid a collective blackout by individually reducing their energy consumption by synchronising and coordinating their actions. Our experimental hypothesis is that collective awareness can be enhanced by appropriate features of the game interface, and therefore to increase the opportunities and prospects for successful collective action (e.g to avoid a blackout)