Physics of the linear collider

This presentation intends to illustrate the specific capabilities of an e$^+$e$^-$ sub-TeV collider to provide answers on the basic issues in physics: origin of mass, hierarchy of masses, cosmological problems. Some foreseeable scenarios are discussed with a possible synergy with LHC.Comment: 20 pages, 16 figure

Signals for Noncommutative QED at Future e+e−e^+e^- Colliders

The signatures for noncommutative QED at $e^+e^-$ colliders with center of mass energies in the range of 0.5-5 TeV are examined. For integrated luminosities of 0.5-1 ab$^{-1}$ or more, sensitivities to the associated mass scales greater than $\sqrt s$ are possible.Comment: LaTex, 6 pages, 6 figs; to appear in the Proceedings of the Fourth International Workshop on $e^-e^-$ Interactions at TeV Energies, UC Santa Cruz, 7-9 Dec 200

The ODO project: a Case Study in Integration of Multimedia Services

Recent years have witnessed a steady growth in the availability of wide-area multi-service networks. These support a variety of traffic types including data, control messages, audio and video. Consequently they are often thought of as integrated media carriers. To date, however, use of these networks has been limited to isolated applications which exhibit very little or no integration amongst themselves. This paper describes a project which investigated organisational, user interfacing and programming techniques to exploit this integration of services at the application level

Histopathology of the gut in rheumatic diseases

The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity to non-self-antigens. Various evidence indicates that intestinal inflammation occurs in patients with rheumatic diseases. In many rheumatic diseases intestinal inflammation appears to be linked to dysbiosis and possibly represents the common denominator in the pathogenesis of different rheumatic diseases. The continuative interaction between dysbiosis and the intestinal immune system may lead to the aberrant activation of immune cells that can re-circulate from the gut to the sites of extraintestinal inflammation as observed in patients with ankylosing spondylitis. The exact contribution of genetic factors in the development of intestinal inflammation in rheumatic diseases needs to be clarified

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis

Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and intestinal immune responses. The presence of intestinal dysbiosis is accompanied in SpA patients with the presence of zonulin-dependent alterations of gut-epithelial and gut-vascular barriers. The leakage of epithelial and endothelial surface layers is followed by the translocation of bacterial products, such as lipopolysaccharide and intestinal fatty acid binding protein, in the systemic circulation. These bacterial products may downregulate the expression of CD14 on circulating monocytes leading to an "anergic" phenotype. In the gut, IL-23 may induce the expansion of innate immune cells such as mucosal-associated invariant T cells, γδ T cells, and innate lymphoid cells of group 3 that through the interaction with MAdCAM1 may recirculate form the gut to the sites of SpA active inflammation. On the basis of these findings, gut inflammation observed in SpA patient seems to be not only an epiphenomenon of the on going systemic inflammatory process but may also represent the base camp in which inflammatory cells are activated and from whom they shuttle

Non-zero density-velocity consistency relations for large scale structures

We present exact kinematic consistency relations for cosmological structures that do not vanish at equal times and can thus be measured in surveys. These rely on cross-correlations between the density and velocity, or momentum, fields. Indeed, the uniform transport of small-scale structures by long wavelength modes, which cannot be detected at equal times by looking at density correlations only, gives rise to a shift in the amplitude of the velocity field that could be measured. These consistency relations only rely on the weak equivalence principle and Gaussian initial conditions. They remain valid in the non-linear regime and for biased galaxy fields. They can be used to constrain non-standard cosmological scenarios or the large-scale galaxy bias.Comment: 5 page

Dynamical critical exponents for the mean-field Potts glass

In this paper we study the critical behaviour of the fully-connected p-colours Potts model at the dynamical transition. In the framework of Mode Coupling Theory (MCT), the time autocorrelation function displays a two step relaxation, with two exponents governing the approach to the plateau and the exit from it. Exploiting a relation between statics and equilibrium dynamics which has been recently introduced, we are able to compute the critical slowing down exponents at the dynamical transition with arbitrary precision and for any value of the number of colours p. When available, we compare our exact results with numerical simulations. In addition, we present a detailed study of the dynamical transition in the large p limit, showing that the system is not equivalent to a random energy model.Comment: 10 pages, 3 figure