Influence of star-forming galaxy selection on the galaxy main sequence

This work aims to determine how the galaxy main sequence (MS) changes using seven different commonly used methods to select the star-forming galaxies within VIPERS data over $0.5 \leq z < 1.2$. The form and redshift evolution of the MS will then be compared between selection methods. The star-forming galaxies were selected using widely known methods: a specific star-formation rate (sSFR), Baldwin, Phillips and Terlevich (BPT) diagram, 4000\AA\ spectral break (D4000) cut and four colour-colour cuts: NUVrJ, NUVrK, u-r, and UVJ. The main sequences were then fitted for each of the seven selection methods using a Markov chain Monte Carlo forward modelling routine, fitting both a linear main sequence and a MS with a high-mass turn-over to the star-forming galaxies. This was done in four redshift bins of $0.50 \leq z < 0.62$, $0.62 \leq z < 0.72$, $0.72 \leq z < 0.85$, and $0.85 \leq z < 1.20$. The slopes of all star-forming samples were found to either remain constant or increase with redshift, and the scatters were approximately constant. There is no clear redshift dependency of the presence of a high-mass turn-over for the majority of samples, with the NUVrJ and NUVrK being the only samples with turn-overs only at low redshift. No samples have turn-overs at all redshifts. Star-forming galaxies selected with sSFR and u-r are the only samples to have no high-mass turn-over in all redshift bins. The normalisation of the MS increases with redshift, as expected. The scatter around the MS is lower than the $\approx$0.3~dex typically seen in MS studies for all seven samples. The lack, or presence, of a high-mass turn-over is at least partially a result of the method used to select star-forming galaxies. However, whether a turn-over should be present or not is unclear.Comment: 20 pages, 3 appendices, 14 figures, 5 tables, accepted for publication in Astronomy & Astrophysic

Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort study.

Background: Response to antipsychotics is subject to a wide interindividual variability, due to genetic and non-genetic factors. Several single nucleotide polymorphisms (SNPs) have been associated with response to antipsychotics in genome-wide association studies (GWAS). Polygenic risk scores (PRS) are a powerful tool to aggregate into a single measure the small effects of multiple risk alleles. Materials and methods: We studied the association between a PRS composed of SNPs associated with response to antipsychotics in GWAS studies (PRS &lt;sub&gt;response&lt;/sub&gt; ) in a real-world sample of patients (N = 460) with different diagnoses (schizophrenia spectrum, bipolar, depressive, neurocognitive, substance use disorders and miscellaneous). Two other PRSs composed of SNPs previously associated with risk of schizophrenia (PRS &lt;sub&gt;schizophrenia1&lt;/sub&gt; and PRS &lt;sub&gt;schizophrenia2&lt;/sub&gt; ) were also tested for their association with response to treatment. Results: PRS &lt;sub&gt;response&lt;/sub&gt; was significantly associated with response to antipsychotics considering the whole cohort (OR = 1.14, CI = 1.03-1.26, p = 0.010), the subgroup of patients with schizophrenia, schizoaffective disorder or bipolar disorder (OR = 1.18, CI = 1.02-1.37, p = 0.022, N = 235), with schizophrenia or schizoaffective disorder (OR = 1.24, CI = 1.04-1.47, p = 0.01, N = 176) and with schizophrenia (OR = 1.27, CI = 1.04-1.55, p = 0.01, N = 149). Sensitivity and specificity were sub-optimal (schizophrenia 62%, 61%; schizophrenia spectrum 56%, 55%; schizophrenia spectrum plus bipolar disorder 60%, 56%; all patients 63%, 58%, respectively). PRS &lt;sub&gt;schizophrenia1&lt;/sub&gt; and PRS &lt;sub&gt;schizophrenia2&lt;/sub&gt; were not significantly associated with response to treatment. Conclusion: PRS &lt;sub&gt;response&lt;/sub&gt; defined from GWAS studies is significantly associated with response to antipsychotics in a real-world cohort; however, the results of the sensitivity-specificity analysis preclude its use as a predictive tool in clinical practice

The Exposure to Osteoarthritic Synovial Fluid Enhances the Immunomodulatory Profile of Adipose Mesenchymal Stem Cell Secretome

Objective. Several clinical studies have proposed the infusion of adipose mesenchymal stem cells (AMSCs) as an alternative therapy for joint diseases with inflammatory components, such as osteoarthritis. Indeed, AMSCs are able to stimulate tissue repair through a paracrine activity and the interaction with the inflammatory microenvironment seems to have a critical role. Design. To reproduce the inflammatory microenvironment, AMSCs were exposed to osteoarthritic synovial fluid (SF) for 48 h and the effect of their secretome on differentiation of monocytes (M0) into macrophages M1-like and mature dendritic cells (mDCs) was evaluated. Furthermore, the effect of the secretome of AMSCs exposed to SF was evaluated on the T cell population in terms of T cell proliferation and expansion of T regulatory cells (T reg). Results. Our data show that the exposure of AMSCs to SF activates cells and promotes the release of immunosuppressive factors, which induce macrophage polarization of M0 into the M2-like phenotype and inhibit differentiation of monocytes into mature dendritic cells (mDCs). Only the secretome of exposed AMSCs was able to inhibit T cell proliferation and promote T reg expansion. Conclusions. Our results suggest that the microenvironment plays a fundamental role for the development of anti-inflammatory and immunomodulatory properties of AMSCs

Decoding the IRX-\beta\ dust attenuation relation in star-forming galaxies at intermediate redshift

We aim to understand what drives the IRX-\beta dust attenuation relation at intermediate redshift (0.5 < z < 0.8) in star-forming galaxies. We investigate the role of various galaxy properties in shaping this observed relation. We use robust [O ii] {\lambda}3727, [O iii] {\lambda}{\lambda}4959, 5007, and H\beta line detections of our statistical sample of 1049 galaxies to estimate the gas-phase metallicities. We derive key physical properties that are necessary to study galaxy evolution, such as the stellar masses and the star formation rates, using the spectral energy distribution fitting tool CIGALE. Equivalently, we study the effect of galaxy morphology (mainly the S\'ersic index n and galaxy inclination) on the observed IRX-\beta scatter. We also investigate the role of the environment in shaping dust attenuation in our sample. We find a strong correlation of the IRX-\beta relation on gas-phase metallicity in our sample, and also strong correlation with galaxy compactness characterized by the S\'ersic indexes. Correlations are also seen with stellar masses, specific star formation rates and the stellar ages of our sources. Metallicity strongly correlates with the IRX-\beta scatter, this also results from the older stars and higher masses at higher beta values. Galaxies with higher metallicities show higher IRX and higher beta values. The correlation with specific dust mass strongly shifts the galaxies away from the IRX-\beta relation towards lower \b{eta} values. We find that more compact galaxies witness a larger amount of attenuation than less compact galaxies. There is a subtle variation in the dust attenuation scatter between edge-on and face-on galaxies, but the difference is not statistically significant. Galaxy environments do not significantly affect dust attenuation in our sample of star-forming galaxies at intermediate redshift.Comment: 14 pages, 13 figures, accepted for publication in A&

Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts.

Studies considering the causal role of body mass index (BMI) for the predisposition of major depressive disorder (MDD) based on a Mendelian Randomization (MR) approach have shown contradictory results. These inconsistent findings may be attributable to the heterogeneity of MDD; in fact, several studies have documented associations between BMI and mainly the atypical subtype of MDD. Using a MR approach, we investigated the potential causal role of obesity in both the atypical subtype and its five specific symptoms assessed according to the Statistical Manual of Mental Disorders (DSM), in two large European cohorts, CoLaus|PsyCoLaus (n = 3350, 1461 cases and 1889 controls) and NESDA|NTR (n = 4139, 1182 cases and 2957 controls). We first tested general obesity measured by BMI and then the body fat distribution measured by waist-to-hip ratio (WHR). Results suggested that BMI is potentially causally related to the symptom increase in appetite, for which inverse variance weighted, simple median and weighted median MR regression estimated slopes were 0.68 (SE = 0.23, p = 0.004), 0.77 (SE = 0.37, p = 0.036), and 1.11 (SE = 0.39, p = 0.004). No causal effect of BMI or WHR was found on the risk of the atypical subtype or for any of the other atypical symptoms. Our findings show that higher obesity is likely causal for the specific symptom of increase in appetite in depressed participants and reiterate the need to study depression at the granular level of its symptoms to further elucidate potential causal relationships and gain additional insight into its biological underpinnings