Special issue: Update on neural oscillations in neuropsychiatric disorders

The present issue highlights recent progress in the analysis of oscillatory activity for the assessment, understanding and remediation of psychiatric and neurologic disorders. Contemporary interest in neural synchrony and oscillations in neuropsychiatric disorders has been motivated by investigations of cellular and network oscillations, modeling of neural networks and advances in signal analysis. Hebb1 proposed that synchronous activation between two neurons strengthened connectivity between them; and that a reverberatory neural circuit could maintain a representation of a stimulus in memory. More recent findings implicate neural synchrony and oscillations in feature binding, attentional selection, arousal, memory operations and consciousness.2-9 Consequently, disturbances of oscillations within and between neural ensembles may contribute to sensory, behavioral and cognitive deficits in neuropsychiatric disorders. Because human EEG and MEG activity are generated by synchronized inhibitory and excitatory post-synaptic potentials within large ensembles of neurons, they are well suited for the detection of neural synchrony and oscillations with millisecond temporal resolution

Critically phase-matched Ti:sapphire-laserpumped deep-infrared femtosecond optical parametric oscillator based on CdSiP2

We report a high-repetition-rate femtosecond optical parametric oscillator (OPO) for the deep-infrared (deep-IR) based on type-I critical phase-matching in CdSiP2 (CSP), pumped directly by a Ti:sapphire laser. Using angle-tuning in the CSP crystal, the OPO can be continuously tuned across 7306–8329 nm (1201–1369  cm−1) in the deep-IR. It delivers up to 18 mW of idler average power at 7306 nm and >7  mW beyond 8000 nm at 80.5 MHz repetition rate, with the spectra exhibiting bandwidths of >150  nm across the tuning range. Moreover, the signal is tunable across 1128–1150 nm in the near-infrared, providing up to 35 mW of average power in ∼266  fs pulses at 1150 nm. Both beams exhibit single-peak Gaussian distribution in TEM00 spatial profile. With an equivalent spectral brightness of ∼5.6×1020photons s−1 mm−2 sr−10.1% BW−1, this OPO represents a viable alternative to synchrotron and supercontinuum sources for deep-IR applications in spectroscopy, metrology, and medical diagnostics.Peer ReviewedPostprint (author's final draft

Femtosecond deep-infrared optical parametric oscillator pumped directly by a Ti:sapphire laser

We report a high-repetition-rate femtosecond optical parametric oscillator (OPO) for the deep-infrared (deep-IR) based on the nonlinear optical crystal, CdSiP2 (CSP), pumped directly by a Ti:sapphire laser, for the first time. By pumping CSP at <1 μm, we have achieved practical output powers at the longest wavelengths generated by any Ti:sapphire-pumped OPO. Using a combination of pump wavelength tuning, type-I critical phase-matching, and cavity delay tuning, we have generated continuously tunable radiation across 6654−8373 nm (1194−1503 cm-1) at 80.5 MHz repetition rate, providing up to 20 mW of average power at 7314 nm and <7 mW beyond 8000 nm, with idler spectra exhibiting bandwidths of 140−180 nm across the tuning range. Moreover, the near-IR signal is tunable across 1127−1192 nm, providing up to 37 mW of average power at 1150 nm. Signal pulses, characterised using intensity autocorrelation, have durations of ∼260–320 fs, with corresponding time-bandwidth product of ∆υ∆τ∼1. The idler and signal output exhibit a TEM00 spatial profile with single-peak Gaussian distribution. With an equivalent spectral brightness of ∼6.68×1020 photons s-1 mm-2 sr-1 0.1% BW-1, this OPO represents a viable table-top alternative to synchrotron and supercontinuum sources for deep-IR applications in spectroscopy, metrology and medical diagnostics.Peer ReviewedPostprint (author's final draft

An exact quantification of backreaction in relativistic cosmology

An important open question in cosmology is the degree to which the Friedmann-Lemaitre-Robertson-Walker (FLRW) solutions of Einstein's equations are able to model the large-scale behaviour of the locally inhomogeneous observable universe. We investigate this problem by considering a range of exact n-body solutions of Einstein's constraint equations. These solutions contain discrete masses, and so allow arbitrarily large density contrasts to be modelled. We restrict our study to regularly arranged distributions of masses in topological 3-spheres. This has the benefit of allowing straightforward comparisons to be made with FLRW solutions, as both spacetimes admit a discrete group of symmetries. It also provides a time-symmetric hypersurface at the moment of maximum expansion that allows the constraint equations to be solved exactly. We find that when all the mass in the universe is condensed into a small number of objects (<10) then the amount of backreaction in dust models can be large, with O(1) deviations from the predictions of the corresponding FLRW solutions. When the number of masses is large (>100), however, then our measures of backreaction become small (<1%). This result does not rely on any averaging procedures, which are notoriously hard to define uniquely in general relativity, and so provides (to the best of our knowledge) the first exact and unambiguous demonstration of backreaction in general relativistic cosmological modelling. Discrete models such as these can therefore be used as laboratories to test ideas about backreaction that could be applied in more complicated and realistic settings.Comment: 13 pages, 9 figures. Corrections made to Tables IV and

Different Approaches to Managerial Support for Flexible Working: Implications for Public Sector Employee Well-Being

Improving well-being is an important human resource management issue within public sector organizations as it is linked with improved employee and organizational outcomes. A key antecedent to employee well-being is work–life balance, which can be supported or impeded by flexible working. The extent to which flexible working supports work–life balance and, ultimately, well-being depends on how flexible working is implemented, where managers play a central role. Managers can enable work–life balance by providing employees with work-family-specific support, which incorporates a range of behaviors, including facilitating access to flexible working. However, research to date says little about how and why managers engage in these behaviors and whether this differs within the same organizational context. This article addresses this gap, presenting four approaches to managerial support for flexible working: unconditional support, performance contingent support, no support, and support based upon the approval of others (transfer responsibility). It explores the reasons for each approach through the lens of Conservation of Resources (COR) theory. It suggests that different approaches create the potential for employee well-being to vary considerably within the same organizational and team context. These findings inform how to support and manage flexible working arrangements in ways that optimize well-being in the public sector

Effects of lovastatin on expression of cell cycle regulatory proteins in vascular smooth muscle cells

Effects of lovastatin on expression of cell cycle regulatory proteins in vascular smooth muscle cells.BackgroundThe sequential appearance of cyclins D and E is thought to initiate subsequent DNA synthesis in proliferating cells. Previous studies have reported that DNA synthesis in cultured rat vascular smooth muscle cells (VSMCs) was suppressed by the HMG-CoA reductase inhibitor lovastatin. The effects of lovastatin on cell cycle regulatory proteins in proliferating VSMCs, however, are largely unknown. Thus, we investigated the sequential expression of cyclin D1, cyclin E, cyclin-dependent kinase (CDK) 4, CDK2, and p27Kip1 in cultured rat VSMCs stimulated by platelet-derived growth factor (PDGF)-BB in the presence or absence of lovastatin.MethodsQuiescent VSMCs, with and without lovastatin (20 μ M) pretreatment for nine hours, were stimulated by PDGF-BB (25 ng/ml). The incorporation of tritiated thymidine was done to assess DNA synthesis. VSMC lysates were obtained every 6 hours for up to 36 hours after stimulation and were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis using relevant polyclonal antibodies. Autoradiograms were analyzed using a densitometer.ResultsThe peak expression of cyclins D1 and E occurred at 18 and 30 hours of PDGF stimulation, respectively. Concomitant expression of CDK4 and CDK2 was also observed. The expression of p27Kip1, by contrast, was reduced in association with DNA synthesis. Lovastatin suppressed DNA synthesis and reduced the expression of cyclin D1 and cyclin E, whereas p27Kip1 expression was strongly induced by lovastatin pretreatment. CDK4 and CDK2 expression was unaffected by lovastatin treatment.ConclusionsPDGF-BB induces cyclins D1 and E prior to the onset of DNA synthesis in VSMCs. Lovastatin may suppress DNA synthesis in VSMCs by inducing p27Kip1 and reducing expression of cyclins D1 and E

Charm and Bottom Semileptonic Decays

We review the present status of theoretical attempts to calculate the semileptonic charm and bottom decays and then present a calculation of these decays in the light--front frame at the kinematic point $q^2=0$. This allows us to evaluate the form factors at the same value of $q^2$, even though the allowed kinematic ranges for charm and bottom decays are very different. Also, at this kinematic point the decay is given in terms of only one form factor $A_{0}(0)$. For the ratio of the decay rates given by the E653 collaboration we show that the determination of the ratio of the Cabibbo--Kobayashi--Maskawa (CKM) matrix elements is consistent with that obtained from the unitarity constraint. At present, though, the unitarity method still has greater accuracy. Since comparisons of the semileptonic decays into $\rho$ and either electrons or muons will be available soon from the E791 Fermilab experiment, we also look at the massive muon case. We show that for a range of $q^2$ the $SU(3)_F$ symmetry breaking is small even though the contributions of the various helicity amplitudes becomes more complicated. For $B$ decays, the decay $B \rightarrow K^{*} \ell \bar{\ell}$ at $q^2=0$ involves an extra form factor coming from the photon contribution and so is not amenable to the same kind of analysis, leaving only the decay $B \rightarrow K^{*}\nu \bar{\nu}$ as a possibility. As the mass of the decaying particle increases we note that the $SU(3)$ symmetry becomes badly broken at $q^2=0$.Comment: Latex, 19 pages, two figures are attached, a minor change in the manuscript related to thi

Economics of deficit irrigation utilizing soil moisture probes in the western corn belt

Effective irrigation management is critical for future food supplies and the prosperity of producers engaged in irrigation production. Through a deficit irrigation field experiment, we determine the financial impact on producers caused by changing irrigation costs, corn prices, extreme weather events, and restricting irrigation levels. Results suggest that the optimal economic strategy within our constrained optimization model is to fully irrigate, with the economic impact highly dependent on commodity prices, restriction level, and irrigation costs. The greatest economic losses caused by irrigation restrictions come from decreases in yield. Some simulations resulted in negative profits, indicating that a switch to alternative crops requiring less irrigation may be warranted

Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity

Approximately 20  % of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm -forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment and to assess antimicrobial activity of common denture cleansers against these tenacious communities. C. albicans isolated from dentures of healthy and diseased individuals was quantified using real-time PCR and biofilm biomass assessed using crystal violet. Biofilm development on the denture substratum poly(methyl methacrylate), Molloplast B and Ufi-gel was determined. Biofilm formation was assessed using metabolic and biomass stains, following treatment with denture hygiene products. Although C. albicans was detected in greater quantities in diseased individuals, it was not associated with increased biofilm biomass. Denture substrata were shown to influence biofilm biomass, with poly(methyl methacrylate) providing the most suitable environment for C. albicans to reside. Of all denture hygiene products tested, Milton had the most effective antimicrobial activity, reducing biofilm biomass and viability the greatest. Overall, our results highlight the complex nature of denture- related disease, and disease development cannot always be attributed to a sole cause. It is the distinct combination of various factors that ultimately determines the pathogenic outcome