Hawking radiation as tunneling from a Vaidya black hole in noncommutative gravity

In the context of a noncommutative model of coordinate coherent states, we present a Schwarzschild-like metric for a Vaidya solution instead of the standard Eddington-Finkelstein metric. This leads to the appearance of an exact $(t - r)$ dependent case of the metric. We analyze the resulting metric in three possible causal structures. In this setup, we find a zero remnant mass in the long-time limit, i.e. an instable black hole remnant. We also study the tunneling process across the quantum horizon of such a Vaidya black hole. The tunneling probability including the time-dependent part is obtained by using the tunneling method proposed by Parikh and Wilczek in terms of the noncommutative parameter $\sigma$. After that, we calculate the entropy associated to this noncommutative black hole solution. However the corrections are fundamentally trifling; one could respect this as a consequence of quantum inspection at the level of semiclassical quantum gravity.Comment: 19 pages, 5 figure

Entropic force approach in a noncommutative charged black hole and the equivalence principle

Recently, Verlinde has suggested a novel model of duality between thermodynamics and gravity which leads to an emergent phenomenon for the origin of gravity and general relativity. In this paper, we investigate some features of this model in the presence of noncommutative charged black hole by performing the method of coordinate coherent states representing smeared structures. We derive several quantities, e.g. temperature, energy and entropic force. Our approach clearly exhibits that the entropic force on a smallest fundamental cell of holographic surface with radius $r_0$ is halted. Accordingly, we can conclude that the black hole remnants are absolutely inert without gravitational interactions. So, the equivalence principle of general relativity is contravened due to the fact that it is now possible to find a difference between the gravitational and inertial mass. In other words, the gravitational mass in the remnant size does not emit any gravitational field, therefore it is experienced to be zero, contrary to the inertial mass. This phenomenon illustrates a good example for a feasible experimental confirmation to the entropic picture of Newton's Second law in very short distances.Comment: 11 pages, 2 figure

Evaluating equality in prescribing Novel Oral Anticoagulants (NOACs) in England: the protocol of a Bayesian small area analysis

Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting about 1.6% of the population in England. Novel oral anticoagulants (NOACs) are approved AF treatments that reduce stroke risk. In this study, we estimate the equality in individual NOAC prescriptions with high spatial resolution in Clinical Commissioning Groups (CCGs) across England from 2014 to 2019. Methods A Bayesian spatio-temporal model will be used to estimate and predict the individual NOAC prescription trend on ‘prescription data’ as an indicator of health services utilisation, using a small area analysis methodology. The main dataset in this study is the “Practice Level Prescribing in England,” which contains four individual NOACs prescribed by all registered GP practices in England. We will use the defined daily dose (DDD) equivalent methodology, as recommended by the World Health Organization (WHO), to compare across space and time. Four licensed NOACs datasets will be summed per 1,000 patients at the CCG-level over time. We will also adjust for CCG-level covariates, such as demographic data, Multiple Deprivation Index, and rural-urban classification. We aim to employ the extended BYM2 model (space-time model) using the RStan package. Discussion This study suggests a new statistical modelling approach to link prescription and socioeconomic data to model pharmacoepidemiologic data. Quantifying space and time differences will allow for the evaluation of inequalities in the prescription of NOACs. The methodology will help develop geographically targeted public health interventions, campaigns, audits, or guidelines to improve areas of low prescription. This approach can be used for other medications, especially those used for chronic diseases that must be monitored over time

Black Hole Evaporation in a Noncommutative Charged Vaidya Model

The aim of this paper is to study the black hole evaporation and Hawking radiation for a noncommutative charged Vaidya black hole. For this purpose, we determine spherically symmetric charged Vaidya model and then formulate a noncommutative Reissner-Nordstr$\ddot{o}$m-like solution of this model which leads to an exact $(t-r)$ dependent metric. The behavior of temporal component of this metric and the corresponding Hawking temperature is investigated. The results are shown in the form of graphs. Further, we examine the tunneling process of the charged massive particles through the quantum horizon. It is found that the tunneling amplitude is modified due to noncommutativity. Also, it turns out that black hole evaporates completely in the limits of large time and horizon radius. The effect of charge is to reduce the temperature from maximum value to zero. It is mentioned here that the final stage of black hole evaporation turns out to be a naked singularity.Comment: 25 pages, 36 figures, accepted for publication in J. Exp. Theor. Phy

Targeting delivery of lipocalin 2-engineered mesenchymal stem cells to colon cancer in order to inhibit liver metastasis in nude mice

One of the major obstacles in cancer therapy is the lack of anticancer agent specificity to tumor tissues. The strategy of cell-based therapy is a promising therapeutic option for cancer treatment. The specific tumor-oriented migration of mesenchymal stem cells (MSCs) makes them a useful vehicle to deliver anticancer agents. In this study, we genetically manipulated bone marrow-derived mesenchymal stem cells with their lipocalin 2 (Lcn2) in order to inhibit liver metastasis of colon cancer in nude mice. Lcn2 was successfully overexpressed in transfected MSCs. The PCR results of SRY gene confirmed the presence of MSCs in cancer liver tissue. This study showed that Lcn2-engineered MSCs (MSC-Lcn2) not only inhibited liver metastasis of colon cancer but also downregulated the expression of vascular endothelial growth factor (VEGF) in the liver. Overall, MSCs by innate tropism toward cancer cells can deliver the therapeutic agent, Lcn2, and inhibit cancer metastasis. Hence, it could be a new modality for efficient targeted delivery of anticancer agent to liver metastasis. © 2015, International Society of Oncology and BioMarkers (ISOBM)

Anatomy of the AGN in NGC 5548 I. A global model for the broadband spectral energy distribution

An extensive multi-satellite campaign on NGC 5548 has revealed this archetypal Seyfert-1 galaxy to be in an exceptional state of persistent heavy absorption. Our observations taken in 2013–2014 with XMM-Newton, Swift, NuSTAR, INTEGRAL, Chandra, HST and two ground-based observatories have together enabled us to establish that this unexpected phenomenon is caused by an outflowing stream of weakly ionised gas (called the obscurer), extending from the vicinity of the accretion disk to the broad-line region. In this work we present the details of our campaign and the data obtained by all the observatories. We determine the spectral energy distribution of NGC 5548 from near-infrared to hard X-rays by establishing the contribution of various emission and absorption processes taking place along our line of sight towards the central engine. We thus uncover the intrinsic emission and produce a broadband continuum model for both obscured (average summer 2013 data) and unobscured (<2011) epochs of NGC 5548. Our results suggest that the intrinsic NIR/optical/UV continuum is a single Comptonised component with its higher energy tail creating the “soft X-ray excess”. This component is compatible with emission from a warm, optically-thick corona as part of the inner accretion disk. We then investigate the effects of the continuum on the ionisation balance and thermal stability of photoionised gas for unobscured and obscured epochs

Wave Packets Propagation in Quantum Gravity

Wave packet broadening in usual quantum mechanics is a consequence of dispersion behavior of the medium which the wave propagates in it. In this paper, we consider the problem of wave packet broadening in the framework of Generalized Uncertainty Principle(GUP) of quantum gravity. New dispersion relations are derived in the context of GUP and it has been shown that there exists a gravitational induced dispersion which leads to more broadening of the wave packets. As a result of these dispersion relations, a generalized Klein-Gordon equation is obtained and its interpretation is given.Comment: 9 pages, no figur

The Swift-UVOT ultraviolet and visible grism calibration

We present the calibration of the Swift UVOT grisms, of which there are two, providing low-resolution field spectroscopy in the ultraviolet and optical bands respectively. The UV grism covers the range 1700-5000 Angstrom with a spectral resolution of 75 at 2600 Angstrom for source magnitudes of u=10-16 mag, while the visible grism covers the range 2850-6600 Angstrom with a spectral resolution of 100 at 4000 Angstrom for source magnitudes of b=12-17 mag. This calibration extends over all detector positions, for all modes used during operations. The wavelength accuracy (1-sigma) is 9 Angstrom in the UV grism clocked mode, 17 Angstrom in the UV grism nominal mode and 22 Angstrom in the visible grism. The range below 2740 Angstrom in the UV grism and 5200 Angstrom in the visible grism never suffers from overlapping by higher spectral orders. The flux calibration of the grisms includes a correction we developed for coincidence loss in the detector. The error in the coincidence loss correction is less than 20%. The position of the spectrum on the detector only affects the effective area (sensitivity) by a few percent in the nominal modes, but varies substantially in the clocked modes. The error in the effective area is from 9% in the UV grism clocked mode to 15% in the visible grism clocked mode .Comment: 27 pages, 31 figures; MNRAS accepted 23 February 201

Interstellar oxygen along the line of sight of Cygnus X-2

Interstellar dust permeates our Galaxy and plays an important role in many physical processes in the diffuse and dense regions of the interstellar medium. High-resolution X-ray spectroscopy, coupled with modelling based on laboratory dust measurements, provides a unique probe to investigate the interstellar dust properties along our line of sight towards Galactic X-ray sources. Here, we focus on the oxygen content of the interstellar medium through its absorption features in the X-ray spectra. To model the dust features, we perform a laboratory experiment using the electron microscope facility located at the University of Cadiz in Spain, where we acquire new laboratory data in the oxygen K-edge. We study 18 dust samples of silicates and oxides with different chemical compositions. The laboratory measurements are adopted for our astronomical data analysis. We carry out a case study on the X-ray spectrum of the bright low-mass X-ray binary Cygnus X-2, observed by XMM-Newton. We determine different temperature phases of the ISM, and parameterize oxygen in both gas (neutral and ionised) and dust form. We find Solar abundances of oxygen along the line of sight towards the source. Due to both the relatively low depletion of oxygen into dust form and the shape of the oxygen cross section profiles, it is challenging to determine the precise chemistry of interstellar dust. However, silicates provide an acceptable fit. Finally, we discuss the systematic discrepancies in the atomic (gaseous phase) data of the oxygen edge spectral region using different X-ray atomic databases, and also consider future prospects for studying the ISM with the Arcus concept mission.Comment: Accepted for publication in A&A, 15 pages, 11 figure