Creating Progam Logic Models: A Toolkit for State Flex Programs

A logic modeling toolkit developed by the Flex Monitoring Team is available for use by state Medicare Rural Hospital Flexibility Programs (Flex Programs) in planning for and managing their Flex programs. The use of the Program Logic Model (PLM) Toolkit will provide states with a tool to assist in: Planning, managing, reporting on, and assessing their Flex Program goals, activities, and accomplishments; Developing buy-in among key Flex Program stakeholders; Clarifying the underlying program assumptions; Identifying and defining measurable outcomes; Linking state-level Flex Program strategies and activities to specific and measurable outcomes; and Reporting program results to both internal and external stakeholders. The PLM Toolkit is organized according to the steps in the PLM development process and guides the user through each section. Included in the Toolkit is an overview of PLMs, their component parts, and the application of the PLM framework to the planning, implementation, and evaluation of the Flex Program. The bulk of the Toolkit provides a step-by-step approach to developing a Program Logic Model. The final section of the Toolkit lists resources for additional information on PLMs

AGMIAL: implementing an annotation strategy for prokaryote genomes as a distributed system

We have implemented a genome annotation system for prokaryotes called AGMIAL. Our approach embodies a number of key principles. First, expert manual annotators are seen as a critical component of the overall system; user interfaces were cyclically refined to satisfy their needs. Second, the overall process should be orchestrated in terms of a global annotation strategy; this facilitates coordination between a team of annotators and automatic data analysis. Third, the annotation strategy should allow progressive and incremental annotation from a time when only a few draft contigs are available, to when a final finished assembly is produced. The overall architecture employed is modular and extensible, being based on the W3 standard Web services framework. Specialized modules interact with two independent core modules that are used to annotate, respectively, genomic and protein sequences. AGMIAL is currently being used by several INRA laboratories to analyze genomes of bacteria relevant to the food-processing industry, and is distributed under an open source license

Rural Families More Likely to be Uninsured and Have Different Sources of Coverage

This study used the 2001/2002 Medical Expenditure Panel Survey (MEPS), conducted by the Agency for Healthcare Research and Quality (AHRQ), to examine the patterns of insurance coverage within rural families and to assess differences in family-level insurance status for rural and urban families (including comparisons between rural families living adjacent to and not adjacent to an urban area). Among partially uninsured families, we examined rural-urban differences in the sources of family coverage for insured family members (Medicare, Medicaid/ SCHIP, private, or a combination)

Intrauterine Blood Plasma Platelet-Therapy Mitigates Persistent Breeding-Induced Endometritis, Reduces Uterine Infections, and Improves Embryo Recovery in Mares

Microorganisms, including pathogenic or opportunistic bacteria and fungi, may gain access to the uterus during breeding, and infectious endometritis plays a major role in equine subfertility. This study aimed to assess the post-breeding inflammatory response, endometrial culture, and embryo recovery of mares susceptible to persistent breeding-induced endometritis (PBIE) treated with plasma-rich (PRP) or -poor (PPP) plasma. Mares (n = 12) susceptible to PBIE had three cycles randomly assigned to receive intrauterine infusions of lactate ringer solution (LRS, control), or autologous PRP or PPP pre- (−48 and −24 h) and post-breeding (6 and 24 h). Mares were bred with fresh semen from one stallion. Intrauterine fluid accumulation (IUF) and endometrial neutrophils were assessed every 24 h up to 96 h post-breeding. Uterine cytokines (Ilβ, IL6, CXCL8, and IL10) were evaluated before (0 h), 6, and 24 h post-breeding, and endometrial culture three and nine days after breed. Embryo flushing was performed 8 days post-ovulation. Data were analyzed with mixed model, Tukey’s post-hoc test, and multivariate regression. PRP treatment reduced endometrial neutrophils, post-breeding IUF, and pro-inflammatory cytokines when compared to control-assigned cycles, but not significantly different than PPP. Controls had a significantly higher percentage of positive bacterial cultures (33%) in comparison to PRP-assigned cycles (0%), whereas cycles treated with PPP were not significantly different from the other groups (25%). The PRP-assigned cycles had significantly greater embryo recovery rates (83%) than the control (33%), though not significantly different than PPP (60%). Plasma infusion reduced the duration and intensity of the post-breeding inflammatory response and improved embryo recovery in mares susceptible to PBIE. Platelets incrementally downregulate PBIE and appear to have a dose-dependent antimicrobial property

Topos Theory and Consistent Histories: The Internal Logic of the Set of all Consistent Sets

A major problem in the consistent-histories approach to quantum theory is contending with the potentially large number of consistent sets of history propositions. One possibility is to find a scheme in which a unique set is selected in some way. However, in this paper we consider the alternative approach in which all consistent sets are kept, leading to a type of `many world-views' picture of the quantum theory. It is shown that a natural way of handling this situation is to employ the theory of varying sets (presheafs) on the space \B of all Boolean subalgebras of the orthoalgebra \UP of history propositions. This approach automatically includes the feature whereby probabilistic predictions are meaningful only in the context of a consistent set of history propositions. More strikingly, it leads to a picture in which the `truth values', or `semantic values' of such contextual predictions are not just two-valued (\ie true and false) but instead lie in a larger logical algebra---a Heyting algebra---whose structure is determined by the space \B of Boolean subalgebras of \UP.Comment: 28 pages, LaTe

AGMIAL: implementing an annotation strategy for prokaryote genomes as a distributed system

We have implemented a genome annotation system for prokaryotes called AGMIAL. Our approach embodies a number of key principles. First, expert manual annotators are seen as a critical component of the overall system; user interfaces were cyclically refined to satisfy their needs. Second, the overall process should be orchestrated in terms of a global annotation strategy; this facilitates coordination between a team of annotators and automatic data analysis. Third, the annotation strategy should allow progressive and incremental annotation from a time when only a few draft contigs are available, to when a final finished assembly is produced. The overall architecture employed is modular and extensible, being based on the W3 standard Web services framework. Specialized modules interact with two independent core modules that are used to annotate, respectively, genomic and protein sequences. AGMIAL is currently being used by several INRA laboratories to analyze genomes of bacteria relevant to the food-processing industry, and is distributed under an open source license

The geographic mosaic of herbicide resistance evolution in the common morning glory, Ipomoea purpurea: Evidence for resistance hotspots and low genetic differentiation across the landscape

Strong human‐mediated selection via herbicide application in agroecosystems has repeatedly led to the evolution of resistance in weedy plants. Although resistance can occur among separate populations of a species across the landscape, the spatial scale of resistance in many weeds is often left unexamined. We assessed the potential that resistance to the herbicide glyphosate in the agricultural weed Ipomoea purpurea has evolved independently multiple times across its North American range. We examined both adaptive and neutral genetic variations in 44 populations of I. purpurea by pairing a replicated dose–response greenhouse experiment with SSR genotyping of experimental individuals. We uncovered a mosaic pattern of resistance across the landscape, with some populations exhibiting high‐survival postherbicide and other populations showing high death. SSR genotyping revealed little evidence of isolation by distance and very little neutral genetic structure associated with geography. An approximate Bayesian computation (ABC) analysis uncovered evidence for migration and admixture among populations before the widespread use of glyphosate rather than the very recent contemporary gene flow. The pattern of adaptive and neutral genetic variations indicates that resistance in this mixed‐mating weed species appears to have evolved in independent hotspots rather than through transmission of resistance alleles across the landscape.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/113156/1/eva12290_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/113156/2/eva12290.pd

Idealism and the metaphysics of individuality

© 2015, © The Author(s) 2015. What is arguably the central criticism of Hegel’s philosophical system by the Continental tradition, a criticism which represents a unifying thread in the diverse work of Schelling, Feuerbach, Kierkegaard, Nietzsche and Adorno, is that Hegel fails to do justice to the notion of individuality. My aim in this article is to counter the claim that Hegel’s idea of the concrete universal fails to properly explain the real uniqueness of individuals. In what follows, I argue that while the Continental critique (as it is particularly expressed by Adorno) is prima facie attractive, it is ultimately misguided.This is because the critics of Hegel fail to correctly understand (1) his principal argument in ‘Sense-Certainty’; (2) crucial features of his logico-metaphysics; and (3) his notion of wholeness. I contend that carefully explicating these important parts of the Hegelian system not only shows that Hegel’s metaphysical commitments are not those that do not leave meaningful room for or make adequate sense of individuality, but that they also reveal a sophisticated treatment of the interdependency between the categories of individuality, particularity and universality in a way which conceives of individuality robustly