Pengaruh Pengungkapan Sosial dan Lingkungan terhadap Asimetri Informasi Bagi Investor (Studi Empiris pada Perusahaan Manufaktur yang Terdaftar di Bei Tahun 2012-2013)

This research aimed to examine the effect of disclosure of social and environmental disclosure to the asymmetry of information in the annual report issued by the company. This research examinedthe annual reports of 100 companies that perform voluntary disclosure is disclosure of social and environmental disclosure in the Indonesia Stock Exchange since 2012-2013. Disclosure of socialand environmental disclosure be investigated by using the method of content analysis. The research uses secondary data based on random sampling method. Method of data processing using a linear OLS regression with a significant level of 10%. The results show that the disclosure of social andenvironmental disclosure affect the asymmetry of information in the annual report and each disclosure have a negative direction, which means the higher the disclosure of social andenvironmental disclosure will reduce the asymmetry of information

Molecular mechanism for bidirectional regulation of CD44 for lipid raft affiliation by palmitoylations and PIP2

The co-localization of Cluster-of-Differentiation-44 protein (CD44) and cytoplasmic adaptors in specific membrane environments is crucial for cell adhesion and migration. The process is controlled by two different pathways: On the one hand palmitoylation keeps CD44 in lipid raft domains and disables the linking to the cytoplasmic adaptor, whereas on the other hand, the presence of phosphatidylinositol-4,5-biphosphate (PIP2) lipids accelerates the formation of the CD44-adaptor complex. The molecular mechanism explaining how CD44 is migrating into and out of the lipid raft domains and its dependence on both palmitoylations and the presence of PIP2 remains, however, elusive. In this study, we performed extensive molecular dynamics simulations to study the raft affinity and translocation of CD44 in phase separated model membranes as well as more realistic plasma membrane environments. We observe a delicate balance between the influence of the palmitoylations and the presence of PIP2 lipids: whereas the palmitoylations of CD44 increases the affinity for raft domains, PIP2 lipids have the opposite effect. Additionally, we studied the association between CD44 and the membrane adaptor FERM in dependence of these factors. We find that the presence of PIP2 lipids allows CD44 and FERM to associate in an experimentally observed binding mode whereas the highly palmitoylated species shows no binding affinity. Together, our results shed light on the sophisticated mechanism on how membrane translocation and peripheral protein association can be controlled by both protein modifications and membrane composition

The Search for Low-mass Companions of B Stars in the Carina Nebula Cluster Trumpler 16

We have developed lists of likely B3--A0 stars (called "late B" stars) in the young cluster Trumpler 16. The following criteria were used: location within 3' of Eta Car, an appropriate V and B-V combination, and proper motion (where available). Color and magnitude cuts have been made assuming an E(B-V) =0.55 mag +/- 0.1, which is a good approximation close to the center of Trumpler 16. These lists have been cross-correlated with X-ray sources found in the Chandra Carina Complex Project (CCCP). Previous studies have shown that only very rarely (if at all) do late main sequence B stars produce X-rays. We present evidence that the X-ray detected sources are binaries with low-mass companions, since stars less massive than 1.4 Msun are strong X-ray sources at the age of the cluster. Both the median X-ray energies and X-ray luminosities of these sources are in good agreement with values for typical low-mass coronal X-ray sources. We find that 39% of the late B stars based on a list with proper motions have low-mass companions. Similarly, 32% of a sample without proper motions have low-mass companions. We discuss the X-ray detection completeness. These results on low-mass companions of intermediate mass stars are complementary to spectroscopic and interferometric results, and probe new parameter space of low mass companions at all separations. They do not support a steeply rising distribution of mass ratios to low masses for intermediate-mass (5 Msun) primaries, such as would be found by random pairing from the Initial Mass Function.Comment: Accepted for the ApJS Special Issue on the Chandra Carina Complex Project (CCCP), scheduled for publication in May 2011. All 16 CCCP Special Issue papers are available at http://cochise.astro.psu.edu/Carina_public/special_issue.html through 2011 at leas

LiFePO4 spray drying scale-up and carbon-cage for improved cyclability

The growing market for electrical vehicles requires inexpensive, long-lasting batteries. LiFePO4 (LFP) melt-synthesized from ore concentrate fits this role, but the manufacturing process requires additional steps that includes grinding large ingots into a nanoparticle suspension followed by a dessication step. Spray drying, rather than tray drying, creates a mesopomus powder that enhances wettability. Adding lactose and high-Mw polyvinyl alcohol (PVA) to the suspension of nanostructures followed by pyrolysis, creates a carbon-cage that interconnects the cathode nanoparticles, imparting better capacity (LiFePO4/C: 161 mA h g(-1) at 0.1C), discharge rate (flat plateau, 145 mA h g(-1) at 5C), and cyclability (91% capacity retention after 750 cycles at 1C). Particle size affects battery stability; PVA increases the suspension's viscosity and alters the powder morphology, from spherical to hollow particles. A model describes the non-Newtonian suspension's rheology changing: shear, temperature, LFP and PVA loading. Carbon precursors prevent the nanoparticles from sintering during calcination but lactose gasifies 50% of the carbon, according to the chemical and allotropic composition measurements (CS analyzer, XPS, and Raman). The carbon-cage imparts micmporosity and we correlate the SEM and TEM powder's morphology with N2 physisorption porosimetry. Ultrasonication of the suspension fragments the PVA chain, which is detrimental to the final cathode performance

Extracapillary proliferation scoring correlates with renal outcome and contributes to stratification in adult patients with immunoglobulin A nephropathy

Background. The revised Oxford classification of diagnostic renal biopsies has been proposed to aid in the prediction of renal outcome. We aimed to validate the histological crescents and interstitial fibrosis and tubular atrophy (IFTA) subgrouping, and to investigate the additional value of the proportion of crescents (CatPE) in the prediction of renal outcome. Methods. Data were retrospectively collected over 10 years, from the time of diagnosis, by systematic review of medical records from 90 patients with renal biopsies recruited to cohorts from two hospitals in Spain. Patients were classified into three groups for the analysis: CatPE >25% (C2), CatPE 50% reduction in glomerular filtrate rate or end-stage renal disease. Results. Renal survival at 5 years was 90% in group C0, 81% in group C1 and 31% in group C2 (P 1⁄4 0.013). The presence of >25% crescents in the sample was associated with more severe disease when compared with 50% had poorer renal function compared with the other groups. Conclusions. We have confirmed the predictive value for renal survival of the revised Oxford classification in a two-centre study. We found worse renal outcome in patients with severe tubulointerstitial fibrosis and atrophy. Patients with extracapillary lesions >25% and IFTA >50% had a worse renal prognosis due to more severe kidney injury. These results contribute to patient stratification in immunoglobulin A nephropathy for therapeutic, epidemiological and basic research

A Qualitative Study of Women's Lived Experiences of Conflict and Domestic Violence in Afghanistan.

This article empirically explores women's lived experiences of domestic violence and conflict in Afghanistan. A thematic analysis of 20 semistructured interviews with women living in safe houses produced three main themes about the relationship between conflict and domestic violence: (a) violence from loss of patriarchal support, (b) violence from the drug trade as an economic driver, and (c) violence from conflict-related poverty. We discuss the bidirectional nature of this relationship: Not only does conflict contribute to domestic violence, but domestic violence contributes to conflict through justifying armed intervention, separating women from economic and public life, and perpetuating patriarchy

Intensive care unit, cardiac care unit, and emergency department nurses' perceptions of medical device-related pressure injuries: a cross-sectional study

Background Nurses' perception of medical device-related pressure injuries (MDRPIs) may affect their performance, but there is a lack of studies in this area. Purpose The current study aimed to examine intensive care unit (ICU), cardiac care unit (CCU) and emergency department nurses' perception of proper prevention of MDRPIs and care for individuals with such injuries. Methods This descriptive study was conducted in 4 general hospitals in Iran in 2021. All nurses (N = 310) working in ICUs, CCUs and emergency departments of these facilities were invited to complete a researcher-made demographic checklist and an 11-item questionnaire to assess attitudes toward MDRPIs. The questionnaire item responses were scored from 1 (strongly agree) to 5 (strongly disagree) with the total score for the 11 items ranging from 11 to 55. A score of 11 to 25 was categorized as indicating a negative attitude toward proper prevention of MDRPIs and care for such patients; a score of 26 to 40 indicated a neutral attitude, and a score >40 indicated a positive attitude. Results A total of 260 nurses fulfilled the data collection tool. The response rate was 83.8%. The mean total score of attitude toward MDRPIs was 41.7. No significant relationship was observed between the total score of nurses' attitudes and their demographic variables. Of the 260 participants, 159 stated they had not received any trainings on MDRPIs at nursing schools during their education, 212 stated they had not participated in any scientific workshops on MDRPIs, and 167 described their knowledge about the prevention and care of MDRPIs as insufficient. Conclusion Among ICU, CCU, and emergency nurses in Iran, most had a positive attitude toward the prevention and care of MDRPIs, but steps should be taken to offer more opportunities for nurses to increase their knowledge in this area

Community structure of Pleistocene coral reefs of Curaçao, Netherlands Antilles

The Quaternary fossil record of living coral reefs is fundamental for understanding modern ecological patterns. Living reefs generally accumulate in place, so fossil reefs record a history of their former biological inhabitants and physical environments. Reef corals record their ecological history especially well because they form large, resistant skeletons, which can be identified to species. Thus, presence-absence and relative abundance data can be obtained with a high degree of confidence. Moreover, potential effects of humans on reef ecology were absent or insignificant on most reefs until the last few hundred years, so that it is possible to analyze "natural" distribution patterns before intense human disturbance began. We characterized Pleistocene reef coral assemblages from Curacao, Netherlands Antilles, Caribbean Sea, focusing on predictability in species abundance patterns from different reef environments over broad spatial scales. Our data set is composed of >2 km of surveyed Quaternary reef. Taxonomic composition showed consistent differences between environments and along secondary environmental gradients within environments. Within environments, taxonomic composition of communities was markedly similar indicating nonrandom species associations and communities composed of species occurring in characteristic abundances. This community similarity was maintained with little change over a 40-km distance. The nonrandom patterns in species abundances were similar to those found in the Caribbean before the effects of extensive anthropogenic degradation of reefs in the late 1970s and early 1980s. The high degree of order observed in species abundance patterns of fossil reef coral communities on a scale of tens of kilometers contrasts markedly with patterns observed in previous small-scale studies of modern reefs. Dominance of Acropora palmata in the reef crest zone and patterns of overlap and nonoverlap of species in the Montastraea ''annularis'' sibling species complex highlight the tendency for distribution and abundance patterns of Pleistocene corals to reflect environmental preferences at multiple spatial scales. Wave energy is probably the most important physical environmental variable structuring these coral communities. The strong similarity between ancient and pre-1980s Caribbean reefs and the nonrandom distribution of coral species in space and time indicate that recent variability noted at much smaller time scales may be due to either unprecedented anthropogenic influences on reefs or fundamentally different patterns at varying spatio-temporal scales