Dusty wind of W Hya. Multi-wavelength modelling of the present-day and recent mass-loss

Low- and intermediate-mass stars go through a period of intense mass-loss at the end of their lives in a phase known as the asymptotic giant branch (AGB). During the AGB a significant fraction of their initial mass is expelled in a stellar wind. This process controls the final stages of their evolution and contributes to the chemical evolution of galaxies. However, the wind-driving mechanism of AGB stars is not yet well understood, especially so for oxygen-rich sources. Characterizing both the present-day mass-loss and wind structure and the evolution of the mass-loss rate of such stars is paramount to advancing our understanding of this processes. We modelled the dust envelope of W Hya using an advanced radiative transfer code. The dust model was analysed in the light of a previously calculated gas-phase wind model and compared to measurements available in the literature, such as infrared spectra, infrared images, and optical scattered light fractions. We find that the dust spectrum of W Hya can partly be explained by a gravitationally bound dust shell that probably is responsible for most of the amorphous Al$_2$O$_3$ emission. The composition of the large ($\sim$\,0.3\,$\mu$m) grains needed to explain the scattered light cannot be constrained, but probably is dominated by silicates. Silicate emission in the thermal infrared was found to originate from beyond 40 AU from the star and we find that they need to have substantial near-infrared opacities to be visible at such large distances. The increase in near-infrared opacity of the dust at these distances roughly coincides with a sudden increase in expansion velocity as deduced from the gas-phase CO lines. Finally, the recent mass loss of W Hya is confirmed to be highly variable and we identify a strong peak in the mass-loss rate that occurred about 3500 years ago and lasted for a few hundred years.Comment: 15 pages, 13 figure

Propulsion and Instability of a Flexible Helical Rod Rotating in a Viscous Fluid

We combine experiments with simulations to investigate the fluid-structure interaction of a flexible helical rod rotating in a viscous fluid, under low Reynolds number conditions. Our analysis takes into account the coupling between the geometrically nonlinear behavior of the elastic rod with a nonlocal hydrodynamic model for the fluid loading. We quantify the resulting propulsive force, as well as the buckling instability of the originally helical filament that occurs above a critical rotation velocity. A scaling analysis is performed to rationalize the onset of this instability. A universal phase diagram is constructed to map out the region of successful propulsion and the corresponding boundary of stability is established. Comparing our results with data for flagellated bacteria suggests that this instability may be exploited in nature for physiological purposes.National Science Foundation (U.S.) (CMMI-1129894

A strategic framework for improving food security in Arab countries

In 2007 and the first half of 2008, a sharp rise in agricultural commodity and food prices triggered grave concerns about food security, malnutrition and increased poverty. While the threat of a prolonged food-price shock receded in the second half of 2008, many factors underlying the price volatility are likely to persist, and will require careful management if future food-price shocks are to be avoided. This paper suggests three strategies that, together, could reduce vulnerability to price shocks: (1) strengthen safety nets, improve access to family planning services, and promote education; (2) enhance domestic food production and improve rural livelihoods through increased investment in research and development to increase productivity; and (3) reduce exposure to market volatility through more efficient supply chains and better use of financial instruments to hedge risk. The challenge of food security will require a global response, involving governments, international and regional funding and lending institutions, United Nations agencies, non-governmental organizations, civil society, and the private sector

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice

There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to optimize the cytokine environment of recipient mice and drug alternatives or complementary to the standard conditioning regimens, that can be significantly modulated. Unfortunately, the high costs related to the use of sophisticated mouse models may limit the application of these models to studies that require an extensive experimental design. Here, using an affordable and convenient method, we demonstrate that the administration of fludarabine (FludaraTM) promotes the extensive and rapid engraftment of human normal hematopoiesis in immunodeficient mice. Quantification of human CD45+ cells in bone marrow revealed approximately a 102-fold increase in mice conditioned with irradiation plus fludarabine. Engrafted cells in the bone marrow included hematopoietic stem cells, as well as myeloid and lymphoid cells. Moreover, this model proved to be sufficient for robust reconstitution of malignant myeloid hematopoiesis, permitting primary acute myeloid leukemia cells to engraft as early as 8 weeks after the transplant. Overall, these results present a novel and affordable model for engraftment of human normal and malignant hematopoiesis in immunodeficient mice

Study of the inner dust envelope and stellar photosphere of the AGB star R Doradus using SPHERE/ZIMPOL

We use high-angular-resolution images obtained with SPHERE/ZIMPOL to study the photosphere, the warm molecular layer, and the inner wind of the close-by oxygen-rich AGB star R Doradus. We present observations in filters V, cntH$\alpha$, and cnt820 and investigate the surface brightness distribution of the star and of the polarised light produced in the inner envelope. Thanks to second-epoch observations in cntH$\alpha$, we are able to see variability on the stellar photosphere. We find that in the first epoch the surface brightness of R Dor is asymmetric in V and cntH$\alpha$, the filters where molecular opacity is stronger, while in cnt820 the surface brightness is closer to being axisymmetric. The second-epoch observations in cntH$\alpha$ show that the morphology of R Dor changes completely in a timespan of 48 days to a more axisymmetric and compact configuration. The polarised intensity is asymmetric in all epochs and varies by between a factor of 2.3 and 3.7 with azimuth for the different images. We fit the radial profile of the polarised intensity using a spherically symmetric model and a parametric description of the dust density profile, $\rho(r)=\rho_\circ r^{-n}$. On average, we find exponents of $- 4.5 \pm 0.5$ that correspond to a much steeper density profile than that of a wind expanding at constant velocity. The dust densities we derive imply an upper limit for the dust-to-gas ratio of $\sim 2\times10^{-4}$ at 5.0 $R_\star$. Given the uncertainties in observations and models, this value is consistent with the minimum values required by wind-driving models for the onset of a wind, of $\sim 3.3\times10^{-4}$. However, if the steep density profile we find extends to larger distances from the star, the dust-to-gas ratio will quickly become too small for the wind of R Dor to be driven by the grains that produce the scattered light.Comment: 10 pages, 8 figures, 4 table

Constraints on the H2O formation mechanism in the wind of carbon-rich AGB stars

Context. The recent detection of warm H$_2$O vapor emission from the outflows of carbon-rich asymptotic giant branch (AGB) stars challenges the current understanding of circumstellar chemistry. Two mechanisms have been invoked to explain warm H$_2$O vapor formation. In the first, periodic shocks passing through the medium immediately above the stellar surface lead to H$_2$O formation. In the second, penetration of ultraviolet interstellar radiation through a clumpy circumstellar medium leads to the formation of H$_2$O molecules in the intermediate wind. Aims. We aim to determine the properties of H$_2$O emission for a sample of 18 carbon-rich AGB stars and subsequently constrain which of the above mechanisms provides the most likely warm H$_2$O formation pathway. Methods, Results, and Conclusions. See paper

The wind of W Hya as seen by Herschel. II. The molecular envelope of W Hya

The evolution of low- and intermediate-mass stars on the asymptotic giant branch (AGB) is mainly controlled by the rate at which these stars lose mass in a stellar wind. Understanding the driving mechanism and strength of the stellar winds of AGB stars and the processes enriching their surfaces with products of nucleosynthesis are paramount to constraining AGB evolution and predicting the chemical evolution of galaxies. In a previous paper we have constrained the structure of the outflowing envelope of W Hya using spectral lines of the $^{12}$CO molecule. Here we broaden this study by modelling an extensive set of H$_{2}$O and $^{28}$SiO lines observed by the three instruments on board Herschel using a state-of-the-art molecular excitation and radiative transfer code. The oxygen isotopic ratios and the $^{28}$SiO abundance profile can be connected to the initial stellar mass and to crucial aspects of dust formation at the base of the stellar wind, respectively. The modelling of H$_{2}$O and $^{28}$SiO confirms the properties of the envelope model of W Hya derived from $^{12}$CO lines. We find an H$_2$O ortho-to-para ratio of 2.5\,$^{+2.5}_{-1.0}$, consistent with what is expected for an AGB wind. The O$^{16}$/O$^{17}$ ratio indicates that W Hya has an initial mass of about 1.5 M$_\odot$. Although the ortho- and para-H$_{2}$O lines observed by HIFI appear to trace gas of slightly different physical properties, a turbulence velocity of $0.7\pm0.1$ km s$^{-1}$ fits the HIFI lines of both spin isomers and those of $^{28}$SiO well. The ortho- and para-H$_2^{16}$O and $^{28}$SiO abundances relative to H$_{2}$ are $(6^{+3}_{-2}) \times 10^{-4}$, $(3^{+2}_{-1}) \times 10^{-4}$, and $(3.3\pm 0.8)\times 10^{-5}$, respectively. Assuming a solar silicon-to-carbon ratio, the $^{28}$SiO line emission model is consistent with about one-third of the silicon atoms being locked up in dust particles

Growth from birth to 6 months of infants with and without intrauterine preeclampsia exposure

Intrauterine preeclampsia exposure affects the lifelong cardiometabolic health of the child. Our study aimed to compare the growth (from birth to 6 months) of infants exposed to either a normotensive pregnancy or preeclampsia and explore the influence of being born small for gestational age (SGA). Participants were children of women participating in the Post-partum, Physiology, Psychology and Paediatric follow-up cohort study. Birth and 6-month weight and length z-scores were calculated for term and preterm (<37 weeks) babies, and change in weight z-score, rapid weight gain (≥0.67 increase in weight z-score) and conditional weight gain z-score were calculated. Compared with normotensive exposed infants (n = 298), preeclampsia exposed infants (n = 84) were more likely to be born SGA (7% versus 23%; P < 0.001), but weight gain from birth to 6 months, by any measure, did not differ between groups. Infants born SGA, irrespective of pregnancy exposure, were more likely to have rapid weight gain and had greater increases in weight z-score compared with those not born SGA. Preeclampsia exposed infants born SGA may benefit from interventions designed to prevent future cardiometabolic disease

Fusionless surgery in early-onset scoliosis

AbstractBackgroundSurgical treatment of early-onset scoliosis has greatly developed in recent years. Early-onset scoliosis covers a variety of etiologies (idiopathic, neurologic, dystrophic, malformative, etc.) with onset before the age of 5 years. Progression and severity threaten respiratory development and may result in respiratory failure in adulthood. Many surgical techniques have been developed in recent years, aiming to protect spinal and thoracic development.Material and methodsPresent techniques are based on one of two main principles. The first consists in posterior distraction of the spine in its concavity (single growing rod, or vertical expandable prosthetic titanium rib [VEPTR]), or on either side (dual rod); this requires iterative surgery, for lengthening, unless motorized using energy provided by a magnetic system. The second option is to use spinal growth force to lengthen the assembly; these techniques (Luque Trolley, Shilla), using a sliding assembly, are known as growth guidance.ResultsThese techniques are effective in controlling early scoliotic deformity, and to some extent restore spinal growth. However, they show a high rate of complications: infection, rod breakage, spinal fixation pull out and, above all, progressive spinal stiffness, reducing long-term efficacy. Respiratory gain is harder to assess, as thoracic expansion does not systematically improve respiratory function, particularly due to impaired compliance of the thoracic cage

Modelling the carbon AGB star R Sculptoris: Constraining the dust properties in the detached shell based on far-infrared and sub-millimeter observations

Context. On the asymptotic giant branch (AGB), Sun-like stars lose a large portion of their mass in an intensive wind and enrich the surrounding interstellar medium with nuclear processed stellar material in the form of molecular gas and dust. For a number of carbon-rich AGB stars, thin detached shells of gas and dust have been observed. These shells are formed during brief periods of increased mass loss and expansion velocity during a thermal pulse, and open up the possibility to study the mass-loss history of thermally pulsing AGB stars. Aims. We study the properties of dust grains in the detached shell around the carbon AGB star R Scl and aim to quantify the influence of the dust grain properties on the shape of the spectral energy distribution (SED) and the derived dust shell mass. Methods. We modelled the SED of the circumstellar dust emission and compared the models to observations, including new observations of Herschel/PACS and SPIRE (infrared) and APEX/LABOCA (sub-millimeter). We derived present-day mass-loss rates and detached shell masses for a variation of dust grain properties (opacities, chemical composition, grain size, and grain geometry) to quantify the influence of changing dust properties to the derived shell mass. Results. The best-fitting mass-loss parameters are a present-day dust mass-loss rate of 2 7 10-10M⊙yr-1and a detached shell dust mass of (2.9 \ub1 0.3) 7 10-5M⊙. Compared to similar studies, the uncertainty on the dust mass is reduced by a factor of 4. We find that the size of the grains dominates the shape of the SED, while the estimated dust shell mass is most strongly affected by the geometry of the dust grains. Additionally, we find a significant sub-millimeter excess that cannot be reproduced by any of the models, but is most likely not of thermal origin