Altimeter height measurement errors introduced by the presence of variable cloud and rain attenuation

It has recently been recognized that spatially inhomogeneous clouds and rain can substantially affect the height precision obtainable from a spaceborne radar altimeter system. Through computer simulation, it has been found that typical levels of cloud and rain intensities and associated spatial variabilities may degrade altimeter precision at 13.5 GHz and, in particular, cause severe degradation at 35 GHz. This degradation in precision is a result of radar signature distortion caused by variable attenuation over the beam limited altimeter footprint. Because attenuation effects increase with frequency, imprecision caused by them will significantly impact on the frequency selection of future altimeters. In this paper the degradation of altimeter precision introduced by idealized cloud and rain configurations as well as for a realistic rain configuration as measured with a ground based radar is examined

European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.

© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It brings together the capabilities of the industry, academics, hospitals, and regulators within a common platform in order to scope the solid understanding of the major issues, which will underpin the progress towards the future of paediatric medicines we want.The EuPFI was formed in parallel to the adoption of regulations within the EU and USA and has served as a community that drives research and dissemination through publications and the organisation of annual conferences. The membership and reach of this group have grown since its inception in 2007 and continue to develop and evolve to meet the continuing needs and ambitions of research into and development of age appropriate medicines. Five diverse workstreams (age-appropriate medicines, Biopharmaceutics, Administration Devices, Excipients and Taste Assessment & Taste Masking (TATM)) direct specific workpackages on behalf of the EuPFI. Furthermore, EuPFI interacts with multiple diverse professional groups across the globe to ensure efficient working in the area of paediatric medicines. Strong commitment and active involvement of all EuPFI stakeholders have proved to be vital to effectively address knowledge gaps related to paediatric medicines, discuss potential areas for further research and identify issues that need more attention and analysis in the future.Peer reviewedFinal Accepted Versio

A continuous low star formation rate in IZw 18 ?

Deep long-slit spectroscopic observations of the blue compact galaxy IZw 18 obtained with the CFH 3.6 m Telescope are presented. The very low value of oxygen abundance previously reported is confirmed and a very homogeneous abundance distribution is found (no variation larger than 0.05 dex) over the whole ionized region. We concur with Tenorio-Tagle (1996) and Devost et al. (1997) that the observed abundance level cannot result from the material ejected by the stars formed in the current burst, and propose that the observed metals were formed in a previous star formation episode. Metals ejected in the current burst of star formation remain most probably hidden in a hot phase and are undetectable using optical spectroscopy. We discuss different scenarios of star formation in IZw 18. Combining various observational facts, for instance the faint star formation rate observed in low surface brightness galaxies van Zee et al. (1997), it is proposed that a low and continuous rate of star formation occurring during quiescent phases between bursts could be a significant source of metal enrichment of the interstellar medium.Comment: 10 pages, 4 Postscript figures, to be published in Astronomy and Astrophysics main journa

Optimization methods applied to the aerodynamic design of helicopter rotor blades

Described is a formal optimization procedure for helicopter rotor blade design which minimizes hover horsepower while assuring satisfactory forward flight performance. The approach is to couple hover and forward flight analysis programs with a general-purpose optimization procedure. The resulting optimization system provides a systematic evaluation of the rotor blade design variables and their interaction, thus reducing the time and cost of designing advanced rotor blades. The paper discusses the basis for and details of the overall procedure, describes the generation of advanced blade designs for representative Army helicopters, and compares design and design effort with those from the conventional approach which is based on parametric studies and extensive cross-plots