Calidad de vida y estrés en estudiantes de medicina en Cajamarca-Perú-2023

Objectives: Determine the influence of quality of life on the stress of medical students at a university in Cajamarca during 2023. Identify the level of quality of life and the degree of stress, and establish the dimensions of quality of life and others. factors that influence stress. Materials and methods: The present study was basic with a quantitative approach, cross-sectional with a correlational method. The student population was 175 students, and the sample was 106 students. The SISCO SV-21 questionnaire with Cronbach's alpha of 0.85 and the WHOQOL-BREF 26 questionnaire with Cronbach's alpha of 0.89 were used. For the treatment of the collected information, descriptive and inferential statistics were used with a level of significance p<0.05 using the Excel statistical package and the Epi Info system. Results: We found 71.70% high levels of stress and 96 % of a low quality of life. A value of p = 0.317 was found with respect to the relationship of the two variables. Regarding the dimensions of the quality of life that predisposes to have high stress, it was found significant to psychological health (p = 0.0025) and PR of 2.88; and social relationships (p= 0.036). Finally, in relation to gender and presentation of stress (significant p of =0.0084) with PR of 1.37. Conclusion: There is no significant correlation between stress and the quality of life of medical students. There are high levels of stress and a feeling of poor quality of life among students. The female sex, mental health and social relationships are significantly related to high levels of stress.Objetivos: Determinar la influencia de la calidad de vida en el estrés de los estudiantes de medicina de una universidad de Cajamarca durante el 2023. Identificar el nivel de calidad de vida y el grado de estrés, y establecer las dimensiones de calidad de vida y otros factores que influyen en el estrés. Materiales y métodos: El presente estudio fue tipo básico con enfoque cuantitativo, de tipo transversal con método correlacional. La población de estudiantes fue de 175 estudiantes, y la muestra fue de 106 estudiantes. Se usó el cuestionario SISCO SV-21 con alfa de Cronbach del 0.85 y el cuestionario WHOQOL-BREF 26 con alfa de Cronbach del 0.89. Para el tratamiento de la información recolectada, se usó la estadística descriptiva e inferencial con un nivel de significancia p<0.05 usando para ello el paquete estadístico Excel y el sistema Epi Info. Resultados: Encontramos un 71,70% altos niveles de estrés y 96% de una calidad de vida baja. Se halló un valor de p = 0.317 con respecto a la relación de las dos variables. Con respecto a las dimensiones de la calidad de vida que predispone a tener estrés alto, se encontró significativo a la salud psicológica (p = 0.0025) y RP de 2.88; y las relaciones sociales (p= 0.036). Finalmente, en relación a sexo y presentación de estrés (p significativo de =0,0084) con RP de 1.37. Conclusión: No existe correlación significativa entre el estrés y la calidad de vida de los estudiantes de medicina, Existen elevados niveles de estrés y de sensación de mala calidad de vida entre los estudiantes. El sexo femenino, la salud mental y las relaciones sociales se relacionan significativamente con elevados de estrés

Mechanical loading induces primary cilia disassembly in tendon cells via TGF beta and HDAC6

D. Rowson was funded through an EPSRC PhD studentship awarded via the Institute of Bioengineering at Queen Mary University of London

Ступінь приверженості до лікування та його ефективність у пацієнтів з гіпертонічною хворобою залежно від способу життя

Vitamin C is a widely used vitamin. Here we review the occurrence and properties of aldonolactone oxidoreductases, an important group of flavoenzymes responsible for the ultimate production of vitamin C and its analogs in animals, plants, and single-cell organisms

Production and functional characterization of two mouse/human chimeric antibodies with specificity for the tumor-associated Tn-antigen.

International audienceIn this work, we have constructed two functional mouse/human chimeric antibodies (IgMkappa and IgG1kappa isotypes) by inserting genomic DNA fragments encoding VH and Vkappa variable regions of the murine monoclonal antibody IgMK-83D4 into mammalian expression vectors containing human mu, gamma1, and kappa constant exons, and by transfecting them into the nonsecreting mouse myeloma X-63 cell line. In previous works, we have demonstrated that 83D4 murine mAb reacts with Tn determinant (GalNAcalpha-O-Ser/Thr) expressed in 90% of breast, ovary, and colon carcinomas. Both expressed chimeric antibodies were purified from the transfected cell line supernatant by affinity chromatography, and their reactivities against Tn antigen were confirmed by ELISA on asialo ovine submaxilar mucin and immunofluorescence studies on MCF-7 breast carcinoma cell line. We have demonstrated by gel filtration chromatography, that the principal secreted forms were monomers for IgG1kappa and pentamers for IgMkappa. The binding affinities of these chimeric antibodies against synthetic Tn glycopeptides, were evaluated by surface plasmon resonance showing an affinity constant similar to that of 83D4 native antibody for IgMkappa and a lower affinity constant for IgG1kappa chimeric antibody. On the other hand, the replacement of mouse C regions with human C regions confers both chimeric antibodies the ability to activate human complement. These mouse/human chimeric antibodies should be much less immunogenic and could play an important role in the lysis of tumor cell expressing Tn-antigen. Therefore, these anti-Tn chimeric antibodies could be considered as potential tools for human in vivo studies